Clinicopathologic Review of Ovarian Masses in Korean Premenarchal Girls

Ki, Eun Young; Byun, Seung Won; Choi, Yoon Jin; Lee, Keun Ho; Park, Jong Sup; Lee, Sung Jong; Hur, Soo Young

doi:10.7150/ijms.6216

Cited by 13 publications

(10 citation statements)

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“…In our study abdominal pain (45.5%) was the most common presenting symptom in concordance with the study by Ki EY et al where the incidence was an abdominal pain (47.7%), palpable abdominal masses (24.6%), incidental ultrasonographic findings (4.6%), and precocious puberty (6.2%). However, in our study one case of granulosa cell tumour presented with precocious puberty (0.89%) and in 4 patients (3.57%) it was incidental finding discovered on prenatal ultrasonography [4]. …”

Section: Discussionmentioning

confidence: 97%

“…It is known that at puberty when menarche begins there are changes in the hormonal levels of the hypothalamus, pituitary gland, and ovaries, so these girls are predisposed to the development of various ovarian masses at puberty [4]. According to Harlan et al, menarche occurs at the age of 9.1 to 17.7 years with a mean age of 13 years [5].…”

Section: Discussionmentioning

confidence: 99%

“…They constitute 10%-25% of all paediatric ovarian neoplasms [4]. Granulosa cell tumours are the most common form of sex cord tumours and are frequently associated with hyperestrogenism or precocious puberty [17-19].…”

Section: Discussionmentioning

confidence: 99%

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Spectrum of Childhood and Adolescent Ovarian Tumors in India: 25 Years Experience at a Single Institution

Rathore

Sharma

Arora

2016

Open Access Maced J Med Sci

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BACKGROUND:Ovarian tumour in children and adolescent girls form an uncommon but important part of gynaecological malignancies. They account for 1% of all the childhood malignancies and 8% of all abdominal tumours in children. Since the ovarian cysts are thought to arise from mature follicles, these tumours were considered to be infrequent in the paediatric population.AIM:The rarity of this condition prompted us to conduct this study and share our experience on the incidence and clinicopathological features of different ovarian tumours in girls up to 20 years of age observed in last 25 years at a single tertiary care hospital.MATERIAL AND METHODS:This was a retrospective study conducted in the Department of Pathology at a tertiary hospital, Delhi. All ovarian tumours up to the age of 20 years in the past 25 years (1990-2014) were included for the purpose of studying the clinicopathological aspects of ovarian tumours in this age group. Descriptive statistics for prevalence and age-wise prevalence was done. Chi-square test, to find an association between the age, laterality and size with malignancy was performed.RESULTS:We received a total of 1102 cases of ovarian tumours over the period of 25 years (1990 to 2014), of which 112 (10%) cases were seen in girls up to 20 years of age. The mean age of the patients was 15.3 ± 4 years. The most common presenting complaint was pain abdomen (46.4 %) There was a statistically significant correlation found between size and malignancy status of tumours in our study (p = 0.00). Of 112 cases of ovarian tumours, 39/112 (34.8%) were malignant and 73/112 (65.2%) were benign. Mature cystic teratoma (27.6%) was the most common type of benign tumour in this age group and immature teratomas were the most common type of malignant ovarian neoplasms.CONCLUSION:Premenarchal girls with ovarian masses may have varied presentations. Abdominal pain is the most common presenting complaint of young adolescent girls with adnexal masses. So the index of suspicion should be kept high and prompt investigations like ultrasound must be performed early to rule out such adnexal masses. Immature Teratoma was the most common malignant and mature cystic teratoma was the most common benign tumour in our study.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Spectrum of Childhood and Adolescent Ovarian Tumors in India: 25 Years Experience at a Single Institution

Rathore

Sharma

Arora

2016

Open Access Maced J Med Sci

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“…Functional cysts, ovarian torsion, and benign neoplasms are the most common ovarian masses in young adolescents (Liu et al, 2013). Ovarian neoplasms are estimated to occur at a rate of approximately 2.6 in 100,000 girls per year (Ki et al, 2013) and malignant ovarian tumors in children and adolescents are rare, accounting for 0.9% of all malignancies (Deligeoroglou et al, 2004). Most ovarian masses are non-neoplastic or benign neoplasms; fewer than 10 percent of ovarian malignancies occur in this age Gulnur Ozaksit, Aytekin Tokmak*, Hatice Kalkan, Huseyin Yesilyurt group (Zhang et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Value of the Platelet to Lymphocyte Ratio in the Diagnosis of Ovarian Neoplasms in Adolescents

Özakşit

Tokmak²,

Kalkan³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Relationships between poor prognosis of ovarian malignancies and changes in complete blood count parameters have been proposed previously. In this work, we aimed to evaluate clinicopathologic features in adolescents with adnexal masses and sought to establish any predictive value of the platelet to lymphocyte ratio (PLR) in diagnosis. Materials and Methods: This retrospective study was conducted on 196 adolescent females with adnexal masses. Three groups were constituted with respect to clinical or histopathology results: group 1, non-neoplastic patients (n:65); group 2, neoplastic patients (n:68); and group 3 expectantly managed patients (n:63). The main parameters recorded from the hospital database and patient files were age, body mass index (BMI), chief symptoms, diameter of the mass (DOM), tumor marker levels, complete blood count values including absolute neutrophil, lymphocyte, and platelet counts, mean platelet volume, platelet distribution width, and platecrit, surgical features, and postoperative histopathology results. Results: The expectantly managed patients were younger than the other groups (p=0.007). The mean body mass index (BMI) was higher in the neoplastic group (p=0.016). Preoperative DOM, CA125, mean platelet volume and PLR were statistically significantly different between the groups (p<0.05). ROC curve analysis demonstrated that increased PLR (AUC, 0.609; p=0.011) and BMI (AUC, 0.611; p=0.011) may be discriminative factors in predicting ovarian neoplasms in adolescents preoperatively. When the cut-off point for the PLR level was set to 140, the sensitivity and specificity levels were found to be 65.7% and 57.6%, respectively. Conclusions: We suggest that beside a careful preoperative evaluation including clinical characteristics, ultrasonographic features and tumor markers, PLR may predict ovarian neoplasms in adolescents.

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“…Our cases are characterized by common premenarchal germ cell tumors and common abdominal pain at presentation similar to other case series [4][5][6][7][8][9]. No documented emergent acute abdomen unlike some reports [10,11].…”

Section: Discussionmentioning

confidence: 60%

Pediatric and Adolescent Malignant Ovarian Tumors: Mansoura 5 - Year Experience

Sarhan¹,

Halim²,

Elzayat³

et al. 2017

JCTI

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Background: Pediatric ovarian tumors are rare. The aim of this work is to study the epidemiological characteristics and treatment outcome of these tumors in our locality. Methods: This retrospective study was performed in accordance with the ethical policies. Between January 2011 to December 2015, Thirteen cases of pediatric ovarian cancers were recorded in the Pediatric Oncology Unit of Oncology Center of Mansoura University and the Clinical Oncology & Nuclear Medicine Department of Mansoura University Hospital. The clinico-epidemiologic data and the treatment protocols were analyzed. Results: The median age was 10 years (range: 2-17). Presenting symptoms were mainly lower abdominal pain (6; 46.2%) and palpable abdominal mass (4; 30.7). Through laparotomy all patients underwent unilateral salpingo-oophorectomy except one case for whom bilateral salpingiooophorectomy was done. Six patients were stage I (46.2%), 2 patients were stage II (15.4%) and 5 patients were stage III tumors (38.4%). The majority had germ cell tumors (11; 85%). Adjuvant chemotherapy was given to all cases. Further chemotherapy was needed in 6 cases due to progression or recurrence. The median follow up was 35 months while the median overall survival was 40 months. Mortality rates were 90% in stages II and III together. The advanced stages and yolk sac pathology had the highest mortality. One of the survived cases got married and delivered a baby. Conclusion: Germ cell tumors are the commonest pediatric malignant ovarian tumors. Multimodality treatment is essential. Fertility preservation should be respected. Our mortality rates are relatively high.

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Clinicopathologic Review of Ovarian Masses in Korean Premenarchal Girls

Cited by 13 publications

References 20 publications

Spectrum of Childhood and Adolescent Ovarian Tumors in India: 25 Years Experience at a Single Institution

Spectrum of Childhood and Adolescent Ovarian Tumors in India: 25 Years Experience at a Single Institution

Value of the Platelet to Lymphocyte Ratio in the Diagnosis of Ovarian Neoplasms in Adolescents

Pediatric and Adolescent Malignant Ovarian Tumors: Mansoura 5 - Year Experience

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