Clinicopathologic patterns of adult renal tumors

Albasri, Abdulkader M.; El-Siddig, Abeer Abdalla; Hussainy, Akbar Shah; Alhujaily, Ahmed Safar

doi:10.4103/sjmms.sjmms_87_16

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…[1][2][3] An even smaller group is found to be strictly localized to the kidney and its surrounding structures, seen in 0.8-2.7% of patients diagnosed with a renal neoplasm. 4,5 A few studies analyzing the characteristics of GU tract sarcomas have been published in recent years. The largest to date in the United States, performed by Dotan et al, described 131 tumors identified over the course of 25 years at a single institution, with 26 (20%) involving the kidney.…”

Section: Introductionmentioning

confidence: 99%

A Contemporary Clinicopathologic Analysis of Primary Sarcomas of the Perinephric Soft Tissue and Hilar Vessels Including a Subset Secondarily Involving the Kidney

et al. 2022

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A variety of primary malignant mesenchymal neoplasms can arise from the perinephric soft tissue and hilar vessels and potentially involve the kidney, mimicking primary renal tumors. A search was made at our institution for patients that underwent radical nephrectomy with associated perinephric or hilar sarcomas from 2010 to 2021. Twenty-six patients were identified. Mean patient age was 60 years (range: 34–83 years), with 16 (62%) females and 10 (38%) males. The mean tumor size was 21.6 cm (range: 8.1–36.5 cm). Among the perinephric/retroperitoneal sarcomas, 14/20 (70%) were dedifferentiated liposarcoma, 4/20 (20%) were well-differentiated liposarcoma, and 2/20 (10%) were leiomyosarcoma. There were 4 grade 1 (20%; all well-differentiated liposarcoma), 9 grade 2 (45%), and 7 grade 3 (35%) tumors. All 6 sarcomas arising from the renal vein/inferior vena cava were leiomyosarcoma: grade 2 in 1 (17%), grade 3 in 4 (67%), and ungraded (due to neoadjuvant therapy effect) in 1 (17%) patient. Four of the 26 (15%) tumors involved the ipsilateral kidney. All 4 tumors were grade 3 sarcomas. On follow-up, 8/26 (31%) patients developed local recurrence and/or metastasis. The mean time for recurrence was 22 months (range: 7–48 months). Two patients progressed with metastasis to the lungs, both of which were grade 3 leiomyosarcoma, and appeared 11 months after the initial diagnosis. Our data suggest that while local recurrence is prevalent with most subtypes of perinephric sarcomas, high-grade leiomyosarcoma has a distinct proclivity for distant metastasis, with the lungs being the most common site.

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Section: Introductionmentioning

confidence: 99%

A Contemporary Clinicopathologic Analysis of Primary Sarcomas of the Perinephric Soft Tissue and Hilar Vessels Including a Subset Secondarily Involving the Kidney

et al. 2022

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“…A study was conducted in Saudi Arabia in the Pathology Department of King Fahad Hospital in 2017 on 42 cases of kidney tumors in adults. RCC accounted for 85.5% of the cases with 66.6% male and 33.3% female and the mean age of 54.5 years (14). A study conducted in India indicated that the prevalence of RCC was 75.2%, of which 90.6% were ccRCC, and 4.7% were PRCC (15).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Renal Cell Carcinoma in Samples Sent to the Pathology Department of Kabul University of Medical Sciences and City Medical Laboratory

2021

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Background: Renal cell carcinoma (RCC) is the most common malignant tumor of the kidney. This tumor originates from the epithelial cells of the renal tubules and is located mainly in the cortical region of the kidney. It constitutes approximately 90% of all kidney malignancies and 2% of all cancers in adults. Objectives: The present study was conducted to determine the prevalence of RCC and its histological subtypes in samples sent to the Pathology Department of Kabul University of Medical Sciences and City Laboratory. Methods: This is a retrospective cohort study of 81 nephrectomy and partial nephrectomy samples registered in the laboratory of the Pathology Department of Kabul University of Medical Sciences and City Medical laboratory database from March 2016 to August 2020. Results: A total of 81 samples were included in this study. The mean and standard deviation (SD) age of the patients was 44.4 ± 20.5. Of 81 samples, 62 (76.6%) were malignant kidney tumors, 13 (16.0%) were inflammatory kidney disease, 4 (4.9%) were polycystic kidney disease, and 2 (2.5%) were benign kidney tumors. Among 62 cases of malignant kidney tumor, 53 (85.48%) were RCC. The high incidence of RCC was in the age group of 56 to 65 years with a mean of 52.2 years; 56.60% of RCC cases were male and 43.39% were female. Based on the histological studies, 75.47% were clear cell renal cell carcinoma (ccRCC) type, followed by 18.86% papillary renal cell carcinoma (PRCC), and 6% chromophobe renal cell carcinoma (ChRCC). Conclusions: Most common malignant tumor of the kidney in the samples included in this study was RCC in the age group of 56 to 65 years and it was more frequent among men compared to women, whereas the most common histological subtype was ccRCC. The findings are in concordance with international literature.

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Histopathological Spectrum of Nephrectomies - A 10 Year Descriptive Study from a Tertiary Care Center in South India

Mohan¹,

Leelamma²,

Vilasiniamma³

et al. 2020

jebmh

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BACKGROUND Nephrectomy is the standard surgical treatment of neoplastic and non-neoplastic lesions in the kidney and provides more insight into the detailed histopathology of renal lesions. We wanted to identify the age groups, gender distribution and different histopathological types and subtypes of non-neoplastic and neoplastic lesions in nephrectomy specimens over a period of ten years. METHODS A retrospective analysis was done over a period of ten years (January 2006 to December 2015). All nephrectomy specimens received in the Department of Pathology, Government Medical College, Kottayam were recorded from histopathology registers and analysed with regard to age, gender and histopathological types. RESULTS A total of 532 lesions was encountered in our analysis. Males (61.8 %) were affected more than females (38.2 %). Lesions were more on the left side (50.8 %) than right side (49.2 %). Non-neoplastic lesions (53 %) outnumbered neoplastic lesions (47 %). Inflammatory and obstructive causes constituted the majority (43.8 %) in non-neoplastic lesions and renal cell carcinoma was the commonest neoplasm (71.2 %). CONCLUSIONS There is a wide age distribution of renal diseases in the present study. Inflammatory and obstructive conditions constituted the most common indication for nephrectomy, followed by malignant tumours. KEYWORDS Renal Cell Carcinoma, Nephrectomy, Pyelonephritis, Simple Renal Cyst, Wilms Tumour

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Clinicopathologic patterns of adult renal tumors

Cited by 3 publications

References 15 publications

A Contemporary Clinicopathologic Analysis of Primary Sarcomas of the Perinephric Soft Tissue and Hilar Vessels Including a Subset Secondarily Involving the Kidney

A Contemporary Clinicopathologic Analysis of Primary Sarcomas of the Perinephric Soft Tissue and Hilar Vessels Including a Subset Secondarily Involving the Kidney

Prevalence of Renal Cell Carcinoma in Samples Sent to the Pathology Department of Kabul University of Medical Sciences and City Medical Laboratory

Histopathological Spectrum of Nephrectomies - A 10 Year Descriptive Study from a Tertiary Care Center in South India

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