Clinicopathologic Parameters in Predicting Cervical Nodal Metastasis in Early Squamous Cell Carcinoma of the Oral Cavity.

Kim, Hyoun Chull; Kusukawa, Jingo; Kameyama, Tadamitsu

doi:10.2739/kurumemedj.40.183

Cited by 22 publications

(10 citation statements)

References 20 publications

(5 reference statements)

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“…Some of the patients without lymph node metastasis at presentation will subsequently manifest metastasis. Since removal of lymph nodes and/or radiation and chemotherapy can reduce emergence of occult metastasis, attempts to predict the patients in this category are made clinically (Kim et al, 1993;Myers et al, 1998). Currently, node-negative patients estimated to have a 20% or greater risk of metastasis often have surgical removal of draining lymph nodes and radiation.…”

Section: Introductionmentioning

confidence: 99%

Gene expression signature predicts lymphatic metastasis in squamous cell carcinoma of the oral cavity

et al. 2004

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Metastasis via the lymphatics is a major risk factor in squamous cell carcinoma of the oral cavity (OSCC). We sought to determine whether the presence of metastasis in the regional lymph node could be predicted by a gene expression signature of the primary tumor. A total of 18 OSCCs were characterized for gene expression by hybridizing RNA to Affymetrix U133A gene chips. Genes with differential expression were identified using a permutation technique and verified by quantitative RT-PCR and immunohistochemistry. A predictive rule was built using a support vector machine, and the accuracy of the rule was evaluated using crossvalidation on the original data set and prediction of an independent set of four patients. Metastatic primary tumors could be differentiated from nonmetastatic primary tumors by a signature gene set of 116 genes. This signature gene set correctly predicted the four independent patients as well as associating five lymph node metastases from the original patient set with the metastatic primary tumor group. We concluded that lymph node metastasis could be predicted by gene expression profiles of primary oral cavity squamous cell carcinomas. The presence of a gene expression signature for lymph node metastasis indicates that clinical testing to assess risk for lymph node metastasis should be possible.

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Section: Introductionmentioning

confidence: 99%

Gene expression signature predicts lymphatic metastasis in squamous cell carcinoma of the oral cavity

et al. 2004

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“…The mortality, secondary to metastasis, has been estimated to be from 20 to 60%. 16 This could be attributed to aggressive local invasion and inaccessibility to tumor due to their metastasis. The management of the neck in early squamous cell carcinomas of the oral cavity has been the subject of debate for many years, since metastasis to the cervical lymph nodes is associated with a significant decrease in survival.…”

Section: Discussionmentioning

confidence: 99%

“…The management of the neck in early squamous cell carcinomas of the oral cavity has been the subject of debate for many years, since metastasis to the cervical lymph nodes is associated with a significant decrease in survival. 16 Oral squamous cell carcinoma has a great predisposition to produce metastasis in cervical lymph nodes. 17 The metastasis to lymph nodes manifests when specific cellular and nuclear changes occur in tumor cells, which represent a distinctive clone.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Nuclear Morphometry in Oral Squamous Cell Carcinoma: A Retrospective Study

Swain¹,

Patel²,

Pathak³

et al. 2017

Journal of Contemporary Dentistry

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Aim: To evaluate and compare various nuclear morphometric parameters in different histopathological grades of oral squamous cell carcinoma (OSCC) by using computerized image analysis and also to correlate it with regional lymph node metastasis. Materials and methods:This retrospective study was conducted on paraffin blocks of 40 tissue specimens of OSCC cases treated with neck dissection, which were retrieved from the archives of the Department of Oral Pathology and Microbiology, Mahatma Gandhi Mission's Dental College and Hospital, Navi Mumbai, India. All cases were histopathologically graded as well, moderately, and poorly differentiated OSCC. Further, they were also categorized based on pathological lymph node status as with or without lymph node metastasis. Sections from tumor proper were subjected to Feulgen nuclear staining technique. Images of 10 microscopic fields at the deepest invading part of tumor were captured randomly and 100 nuclei of tumor cells with clear, complete, nonoverlapping outlines were selected in each case. Nuclear morphometric parameters, such as large diameter, small diameter, nuclear area, and nuclear perimeter were measured for each of the 100 cells.Results: An increase in mean nuclear area coefficient of variation (NACV) was observed in OSCC cases with lymph node metastasis pN(+) than in those without lymph node metastasis pN(-), (p = 0.67). A significant increase in nuclear area and perimeter was observed in pN(+) cases (p < 0.01). A significant decrease in circular rate and increase in largest to smallest nuclear diameter (L/S) ratio (p < 0.01) was observed in pN(+) cases. On comparing the nuclear morphometric parameters with different histopathological grades of OSCC, we found an increase in mean NACV values from well-differentiated OSCC to moderately differentiated and poorly differentiated OSCC significant difference (LSD) post hoc test, indicated a difference only between well-differentiated and poorly differentiated cases of OSCC (p = 0.132). Conclusion:Our observations reveal that tumor cells with greater nuclear dimension and more elliptical shape tend to show increased incidence of nodal metastasis. Also, a positive inclination was observed in nuclear size and shape with increasing histopathological grades of OSCC. However, our data warrant a large-scale study to establish nuclear morphometry as a quantitative objective parameter and also for the rational application of the same.

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“…Single histological variables such as tumor grade, mitotic rate and degree of keratinization have been disappointing with respect to providing additional prognostic information. Tumor thickness for T1 tongue SCC has strongly associated with propensity for lymph node metastasis, and survival (Martinez-Gimeno et al, 1995), but is not a predictor for local recurrence (Kim et al, 1993;Po Wing et al, 2002).…”

Section: Pathology and Tissue Procurementmentioning

confidence: 99%

“…Multiparameter prognostic histological assessments have been developed and refined over the last two decades, based on variables that include pattern of invasion, degree of keratinization, nuclear pleomorphism, lymphocytic response and mitotic rate (Anneroth et al, 1987;Bryne et al, 1989Bryne et al, , 1992Bryne et al, , 1995Kim et al, 1993;Spiro et al, 1999;Bundgaard et al, 2002). Pattern of tumor invasion (POI) refers to the manner in which cancer infiltrates tissue at the tumor/ host interface.…”

Section: Pathology and Tissue Procurementmentioning

confidence: 99%

Head and neck cancer: reduce and integrate for optimal outcome

Belbin

Bergman²,

Brandwein-Gensler

et al. 2007

Cytogenet Genome Res

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Clinicopathologic Parameters in Predicting Cervical Nodal Metastasis in Early Squamous Cell Carcinoma of the Oral Cavity.

Cited by 22 publications

References 20 publications

Gene expression signature predicts lymphatic metastasis in squamous cell carcinoma of the oral cavity

Gene expression signature predicts lymphatic metastasis in squamous cell carcinoma of the oral cavity

Evaluation of Nuclear Morphometry in Oral Squamous Cell Carcinoma: A Retrospective Study

Head and neck cancer: reduce and integrate for optimal outcome

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