Clinicopathologic Features of Resected Primary Adenosquamous Carcinomas of the Liver

Abstract

Four cases of resected adenosquamous carcinoma of the liver were clinicopathologically reviewed, together with immunohistochemical findings. Although no lymph node metastases were seen and a curative resection was achieved in all cases, two patients had recurrences in the peritoneum and distant organs such as the pericardium and pleura relatively soon after the operation. Of the remaining two cases, one patient died during the postoperative period and the other died of coexistent hilar cholangiocarcinoma. Together these findings suggest that this disease tends to spread locally and distantly in the early phase of tumor growth and shows aggressive biological behavior. In an immunohistochemical study, involucrin was a specific marker for the squamous component and CA19-9 was a marker for the adenomatous component.

The comparison of surgical patients with primary hepatic squamous cell carcinoma or adenosquamous carcinoma and surgical patients with hepatocellular carcinoma

“…At present, both of the therapeutic regimes for primary hepatic SCC and ASC are not certain, due to the low incidence and belated definitive diagnosis. Surgical procedures may be a more important treatment for both two [ 6 - 11 , 25 - 33 ]. Besides the resection, previously reported methods included transcatheter arterial infusion chemotherapy (TACE), which was considered to be useful for both primary hepatic SCC and ASC patients [ 22 ].…”

A Clinicopathologic Study of Primary Adenosquamous Carcinoma of the Liver

“…2,[5][6][7][8][9][10][11][12][13] Included in this case study is a 52-year-old male patient who consulted our clinic with liver dysfunction. Laboratory data showed an elevation in alkaline phosphatase, g-glutamyl transpeptidase, and tumor markers such as carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9).…”

“…Of the 65 cases selected for review, including our case, clinicopathologic data were obtained for 42 cases [6][7][8][9][10][11][12][13] (Table 1). For all cases, a complete physical examination and clinical history were described in the literature.…”

Pathological aspects of cholangiocarcinoma

“…Histological variants of CC other than papillary adenocarcinomas are altogether rare (less than 10%) and include mucinous and signet ring cell carcinomas characterized by large amounts of extra‐ and intracellular mucin, adenosquamous carcinomas, squamous cell carcinomas, probably arising from metaplastic squamous epithelium and usually associated with solitary liver cysts 11, mucoepidermoid carcinomas, glycogen‐rich clear cell carcinomas, and spindle cell/undifferentiated carcinomas. The adenosquamous and spindle cell variants appear to have a worse prognosis than classical adenocarcinomas 12–14. A rare type of ICC with a better prognosis than the classical type is the so‐called hepatobiliary cystadenocarcinoma, a papillary adenocarcinoma usually arising in a multilocular cystadenoma or in a unilocular bile duct cyst 15.…”