“…Some T-cell lymphoma entities, like adult T-cell leukemia-lymphoma (ATLL), peripheral T-cell lymphomas-no other specified (PTCL-NOS), ALK-positive ALCL (ALK + ALCL), and ENKTCL seem to be associated with an increased risk of CNS dissemination (Table 1), an event rarely reported in patients with angioimmunoblastic T-cell lymphoma Gurion et al, 2016;Ellin et al, 2015;Kim et al, 2020;Pro and Perini, 2010). CNS involvement occurs in 10-25% of patients with ATLL (Rubenstein et al, 2008;Gurion et al, 2016;Yi et al, 2011;Kim et al, 2010;Teshima et al, 1990), but it is very rare initial diagnosis (Ma et al, 2014); higher risk of CNS relapse is reported in the forms with disseminated disease, such as lymphomatous and acute forms, especially the former, which represents almost half the ATLL patients (Kitajima et al, 2002;Hsi et al, 2014). However, the rate of CNS dissemination in ATLL patients may be underestimated; this is suggested by a study showing that 14 % of ATLL patients without neurological symptoms had evidence of CNS involvement on autopsy (Teshima et al, 1990).…”