Clinicopathologic Features and Prognosis of Young Patients With Hepatocellular Carcinoma in a Large German Cohort

Niederle, Ina M.; Wörns, Marcus‐Alexander; Koch, Sandra; Nguyen-Tat, M; Düber, Christoph; Otto, Gerd; Schuchmann, Marcus; Galle, Peter R.; Weinmann, Arndt

doi:10.1097/mcg.0b013e31826102cc

Cited by 17 publications

(10 citation statements)

References 20 publications

(27 reference statements)

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Section: Discussionmentioning

confidence: 99%

“…In Asian countries with a high prevalence of HBV infection, HCC shows different clinical characteristics compared to that in Western countries, where the incidence of HCC is low and hepatitis C virus (HCV) infection or alcohol abuse is the main risk factor. [21][22][23][24] We previously reported clinical characteristics and outcomes of an HBV-dominant HCC cohort (from 2000 to 2003). 9,10 It was only later that practice guidelines for HCC management were developed in Korea, 12,13 and the use of anti-HBV nucleotide/nucleoside analogues was generalized nationwide.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical outcomes of a cohort series of patients with hepatocellular carcinoma in a hepatitis B virus‐endemic area

Kwak

Park

Nam

et al. 2014

J of Gastro and Hepatol

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical outcomes of a cohort series of patients with hepatocellular carcinoma in a hepatitis B virus‐endemic area

Kwak

Park

Nam

et al. 2014

J of Gastro and Hepatol

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“…The age cut-off of 40 years was based on previous studies. 2 , 12 , 13 , 22 – 25 We defined young patients as aged ≤40 years and older patients as aged >40 years. The clinicopathological features and the prognosis in young patients were compared with those in older patients.…”

Section: Methodsmentioning

confidence: 99%

<p>Prognosis Factors of Young Patients Undergoing Curative Resection for Hepatitis B Virus-Related Hepatocellular Carcinoma: A Multicenter Study</p>

Zeng

Lin

Liu

et al. 2020

CMAR

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Background: The prognosis of young and older patients with hepatocellular carcinoma (HCC) is controversial. We aim to compare the clinicopathological features and prognosis of young (age ≤40 years) versus older patients (aged >40 years) with hepatitis B virus (HBV)related HCC after curative resection. Methods: A total of 4504 patients with HBV-related HCC who underwent curative resection were included in this study and divided into young group (n=699) and older group (n=3805). Subgroup analyses were conducted to compare. Independent risk factors were identified by Cox regression analysis. Results: Young patients had better ALBI grade, lower rates of liver cirrhosis, higher rates of elevated serum AFP levels, larger tumor size, higher rates of microvascular invasion and macrovascular invasion, higher rates of Edmondson grade III-IV, lower rates of tumor capsular, more advanced AJCC TNM stages and more advanced BCLC stages than older patients (All p<0.05). Meanwhile, young patients had a worse overall survival (OS) rate (p=0.0091) and a worse recurrence-free survival (RFS) rate (p=0.045) than older patients. Multivariate analysis revealed that AFP, resection margin, tumor size, tumor capsular, and macrovascular invasion were associated with OS. The independent risk factors associated with RFS were ALB, tumor size, microvascular invasion, and macrovascular invasion. Conclusion: Young patients had better liver function, more aggressive tumor characteristics, and worse prognosis than older patients. A tumor size of ≥5 cm and macrovascular invasion were associated with poor OS and RFS in young patients. If tumors could be detected at the early stage by more frequent surveillance, long-term survival can be expected in the young patients.

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“…We found that the prognosis of young patients was worse than that of older patients but this was not the case after propensity score matching. 22,25,26 The discrepancies in previous studies may reflect differences in ethnicity, cut-off age for defining "younger" and "older", and clinicopathological differences before surgery. We used propensity score matching to reduce potential confounding from baseline differences, allowing us to isolate the effects of age.…”

Section: Discussionmentioning

confidence: 98%

Analysis of Clinicopathological Characteristics and Prognosis of Young Patients with Hepatocellular Carcinoma after Hepatectomy

Li¹,

Chen²,

Liu³

et al. 2020

Journal of Clinical and Translational Hepatology

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Background and Aims: This study was designed to analyze the effects of age and clinicopathological characteristics on prognosis of Chinese patients with hepatocellular carcinoma (HCC). Methods: The clinical data of 2032 HCC patients who were first diagnosed with HCC and underwent curative hepatectomy in our hospital between January 2006 and January 2011 were retrospectively analyzed. Results: Younger HCC patients (age <40 years, n=465) had a significantly higher hepatitis B infection rate, larger tumors, higher alpha-fetoprotein levels, higher preoperative liver function, and more frequent vascular invasions than older patients. Most younger patients were suitable for anatomical hepatectomy, and their tumors were found to be at a highly advanced stage. The recurrence-free survival and overall survival rates of younger HCC patients were significantly worse than those of older patients but this difference disappeared after propensity score matching. Multivariate analysis of pre-matched samples showed that age #40 years was one of the independent risk factors associated with poor overall survival. Conclusions: Younger patients showed different clinicopathological characteristics than older patients, such as higher rates of hepatitis B infection and advanced tumors. The recurrence-free survival and overall survival rates of younger HCC patients after hepatectomy may be similar to those of older patients.

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Clinicopathologic Features and Prognosis of Young Patients With Hepatocellular Carcinoma in a Large German Cohort

Abstract: This western cohort of young patients is distinctly different from described Asian cohorts, especially with regard to a lower rate of underlying liver disease and particularly hepatitis B virus. Young patients had a better overall survival than older patients.

Cited by 17 publications

References 20 publications

Clinical outcomes of a cohort series of patients with hepatocellular carcinoma in a hepatitis B virus‐endemic area

Clinical outcomes of a cohort series of patients with hepatocellular carcinoma in a hepatitis B virus‐endemic area

<p>Prognosis Factors of Young Patients Undergoing Curative Resection for Hepatitis B Virus-Related Hepatocellular Carcinoma: A Multicenter Study</p>

Analysis of Clinicopathological Characteristics and Prognosis of Young Patients with Hepatocellular Carcinoma after Hepatectomy

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