Clinicopathologic Features and Predictors for Survival of Mucinous and Nonmucinous Appendiceal Adenocarcinoma

Abstract

Background/Aims: We report a study in patients with mucinous and nonmucinous appendiceal adenocarcinoma treated surgically whose records were examined to elucidate their clinicopathologic features and prognostic factors for survival. Methods: The medical records of 34 patients with mucinous and nonmucinous appendiceal adenocarcinoma (1991–2005) were retrospectively reviewed. Results: There was no significant difference between mucinous and nonmucinous tumors in patient demographics, clinicopathologic features, type of operation and outcome. Nonmucinous tumors had a higher incidence of leukocytosis than mucinous ones. The overall 5-year survival rate for 34 patients with appendiceal adenocarcinoma was 35.8%. In the univariate analysis, predictors of survival were the type of operation, resectability, carcinomatosis and tumor stage. Tumor stage significantly influenced patient survival in the multivariate analysis. Conclusion: Mucinous appendiceal adenocarcinoma had clinicopathologic characteristics and a prognosis similar to nonmucinous, except that there was more leukocytosis in nonmucinous tumors. Tumor stage is an independent predictor for survival among patients with appendiceal adenocarcinoma.

Trends of incidence and survival in patients with gastrointestinal mucinous adenocarcinoma

“…This increase might partially be attributed to improved detection through advances in endoscopic and radiologic imaging techniques. Compared with MA located in any of the other sites, appendiceal MA has been associated with a younger age at presentation and larger proportions of appendiceal malignancies, which is a finding consistent with other reports ( 19 , 20 ). According to the different grade levels, appendiceal MA appeared to have variable survival outcomes; better OS time than any other sites of the gastrointestinal tract was commonly seen in most stages and grades of appendiceal MA, except for Grade III/IV.…”

Rare Gastrointestinal Tumors: How Often do we Operate on Such Tumors? A Single-Center Study from a Regional Hospital

“…However right hemicolectomy is challenged lately, especially in the presence of peritoneal or nodal metastasis [35]. Survival between mucinous and non-mucinous adenocarcinomas does not differ [36]. One case of a young patient with appendiceal goblet cell carcinoma was presented.…”

An Uncommon Cause of Small Bowel Bleeding from Appendiceal Carcinoma

“…Nonmucinous adenocarcinomas of the appendix generally present with right lower quadrant abdominal pain [9]. The manifestation of massive GI bleeding has never been reported in the nonmucinous type.…”