Clinicopathologic features and histochemical analyses of proliferative activity and angiogenesis in small cell carcinoma of the esophagus

Koide, Naoki; Saito, Hiroyasu; Suzuki, Akira; Sato, Toshiyuki; Koiwai, Keiichiro; Nakamura, Naoshi; Miyagawa, Shinichi

doi:10.1007/s00535-007-2114-0

Cited by 35 publications

(31 citation statements)

References 24 publications

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“…MVD and EA have been experimentally proposed to be biomarkers associated with biological aggressiveness and clinical outcome in animal and human malignancies. In regards to pancreatic cancer, it has been established that angiogenesis has a role in its development and progression (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). In addition, Ki-67 expression is an important parameter for biological aggressiveness and prognosis in tumour tissue; Ki-67 antigens are initially expressed in S-phase and increase throughout S-and G 2 -phase until they reach their peak expression during mitosis.…”

Section: Introductionmentioning

confidence: 99%

Microvascular density and endothelial area correlate with Ki-67 proliferative index in surgically-treated pancreatic ductal adenocarcinoma patients

et al. 2015

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Abstract. Previous experimental and clinical data have indicated that tumour cell proliferation is associated with angiogenesis; in addition, an increased microvascular density (MVD) of tumours has been associated with poor prognosis in solid and haematological malignancies. However, limited data exists regarding the association between tumour cell proliferation and angiogenesis in primary tumour tissue from pancreatic ductal adenocarcinoma (PDAC) patients; therefore, the present study aimed to investigate this association. A series of 31 PDAC patients with stage Tumour (T) [2][3] Node (N) 0-1 Metastasis (M) 0 were recruited into the present study and subsequently underwent surgery. PDAC tissue and adjacent normal tissue (ANT), resected during surgery, were evaluated using immunohistochemistry and image analysis methods to determine MVD, endothelial area (EA) and Ki-67 expression, which is an indicator of cell proliferation rate. The results demonstrated a correlation between the above parameters with each other as well as the main clinico-pathological features of PDAC. Significant differences were identified in MVD, EA and Ki-67 proliferation index between PDAC and ANT. It was demonstrated that MVD, EA and Ki-67 proliferation index were significantly correlated with each other in tumour tissue (r=0.69-0.81; P=0.001-0.003). However, no other significant correlations were identified. These data therefore suggested that angiogenesis and cell proliferation rate were significantly increased in PDAC compared with ANT, which provides a biological basis for the potential use of novel combinations of angiogenesis inhibitors and anti-proliferative chemotherapeutic drugs in the treatment of PDAC.

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Section: Introductionmentioning

confidence: 99%

Microvascular density and endothelial area correlate with Ki-67 proliferative index in surgically-treated pancreatic ductal adenocarcinoma patients

et al. 2015

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“…It remains controversial whether surgery is necessary, because chemotherapy plays a key role in the treatment for patients with esophageal small cell carcinoma [14]. Surgery may contribute to the long-term survival of patients without nodal metastasis, and patients with nodal metastasis have a better chance of long-term survival if the nodal metastasis is controlled or cured by chemotherapy or radiotherapy before surgery [15]. In locoregional disease, the indicated treatment is chemoradiotherapy, and then, if metastatic disease is still excluded, surgical resection can be considered [1].…”

Section: Discussionmentioning

confidence: 99%

Clinical features of primary small cell carcinoma of the thoracic esophagus: a retrospective analysis of 12 surgically resected cases

et al. 2009

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Aim. Primary esophageal small cell carcinoma is a comparatively rare disease. It is thought to have a poor prognosis, and no standard treatment strategy has yet been established. Surgical cases of small cell carcinoma of the thoracic esophagus were reviewed with regard to clinical characteristics and treatment strategy. Patients and methods. Among the 993 patients who underwent an esophagectomy for thoracic esophageal cancer from 1965 to 2007, 12 cases (1.2%) demonstrated a diagnosis of small cell carcinoma based on the histopathology fi ndings. Results. There were 3 cases of Stage I, 1 case of Stage II, 4 cases of Stage III, and 4 cases of Stage IVa. Five cases (42%) were treated preoperatively (chemoradiotherapy, 4 cases; radiotherapy, 1 case), and the pathological criteria for the effects of preoperative therapy were 3 cases of Grade 3. Eleven patients died of cancer; only 1 patient achieved long-term survival and complete response for treatment with chemoradiation after recurrence. The median survival time was 7.6 months, the 1-year survival rate was 33%, and the 3-year survival rate was 8.3%. Conclusions. The prognosis of surgically resected cases of esophageal small cell carcinoma is poor; therefore, either chemotherapy or chemoradiotherapy should be administered to such cases. Furthermore, improved understanding of the biological characteristics of this type of tumor will result in the development of new therapeutic strategies, which are expected to improve patient outcome.

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“…Searching the literature in PubMed and Ichushi-Web using the key word 'small cell carcinoma of esophagus', we found that, between 1998 and 2007, there were 64 reported Japanese cases of SmCC of the esophagus in which the pathological TNM stage and survival was evident, when transthoracic esophagectomy with extended lymph node dissection was applied. There were a total of 47 cases in which esophagectomy was performed as a first-line therapy [5,6,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] . With the information from those 47 cases, we determined when esophagectomy for SmCC of the esophagus is indicated.…”

Section: Discussionmentioning

confidence: 99%

Small Cell Carcinoma of the Esophagus Treated with Esophagectomy and following Chemotherapy: Case Report with Review of the Literature

Usami¹,

Motoyama²,

Maruyama³

et al. 2010

Eur Surg Res

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We report 2 cases of small cell carcinoma of the esophagus treated with esophagectomy as a primary treatment and following chemotherapy. One patient (pT1N1M0) achieved long-term survival, while the other patient (pT1N1M1-lym) died 18 months after surgery. We used reports on 47 Japanese patients receiving esophagectomy as a primary treatment to determine when esophagectomy for small cell carcinoma of the esophagus is indicated. We conclude that esophagectomy as a local treatment provides relatively good long-term survival only in patients without lymph node involvement.

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Clinicopathologic features and histochemical analyses of proliferative activity and angiogenesis in small cell carcinoma of the esophagus

Abstract: Background. We investigated clinicopathologic features of esophageal small cell carcinoma

Cited by 35 publications

References 24 publications

Microvascular density and endothelial area correlate with Ki-67 proliferative index in surgically-treated pancreatic ductal adenocarcinoma patients

Microvascular density and endothelial area correlate with Ki-67 proliferative index in surgically-treated pancreatic ductal adenocarcinoma patients

Clinical features of primary small cell carcinoma of the thoracic esophagus: a retrospective analysis of 12 surgically resected cases

Small Cell Carcinoma of the Esophagus Treated with Esophagectomy and following Chemotherapy: Case Report with Review of the Literature

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