Clinicopathologic Factors Related to Metastasis in Retinoblastoma

Wang, An Guor; Hsu, Wen Ming; Hsia, Wei Wei; Liu, Jorn Hon; Yen, May-Yung

doi:10.3928/0191-3913-20010501-11

Cited by 10 publications

(2 citation statements)

References 17 publications

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“…Tumor invasion and metastases represent the most common causes of mortality 12,13 for which reason several studies have been carried out in order to determine the main risk factors for them. It is estimated that the development of metastatic disease occurs in less than 10% of affected patients 14,15 .…”

Section: Introductionmentioning

confidence: 99%

Late and Distant Metastases of Retinoblastoma to Long Bones: A Purpose of a Case

Willians,

Marin

2023

MRAJ

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The case of a 13-year-old male patient is presented, with a history of Bilateral Retinoblastoma since he was 2 years old, undergoing enucleation of the right eye in June 2007, and salvage of the left eye by chemotherapy and radiotherapy, said patient 11 years after This episode presented metastasis in the distal end of the right radius, performing neoadjuvant treatment and subsequent wide oncological resection with healthy margins of the distal end of the radius plus reconstruction with the proximal end of the ipsilateral fibula and arthrodesis of the wrist. . It is important to point out that distant bone involvement and that of long bones are very few cases reported in the literature, therefore this case was a challenge for diagnosis and treatment, since a retinoblastoma was obtained that metastasized 12 years later. of the enucleation of the eye with the primary tumor and in turn performed it in the long bone (radius), it is emphasized that said patient was followed up free of disease for 2 years after surgery (wrist fusion). Given the limitations of knowledge of the genetics of retinoblastoma metastasis to long bones, not all alterations are currently known. It is considered that a genetic study should be done in patients diagnosed on time.

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Section: Introductionmentioning

confidence: 99%

Late and Distant Metastases of Retinoblastoma to Long Bones: A Purpose of a Case

Willians,

Marin

2023

MRAJ

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“…Another characteristic sign is proptosis secondary to retrobulbar extraocular expansion, orbital cellulitis, or verification of distant metastases [11,12]. Tumor invasion and metastases represent the most common causes of mortality [13,14], for which several studies have been carried out in order to determine the main risk factors for them. It is estimated that the development of metastatic disease occurs in less than 10% of affected patients [15,16].…”

Section: Introductionmentioning

confidence: 99%

Late and Distant Metastases of Retinoblastoma to Long Bones: A Purpose of a Case

Willians¹

2022

Corpus J Clin Trials

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Is presented a 13 year old male patient case, with a history of Bilateral Retinoblastoma since 2 years old, performing enucleation of the right eye in June 2007, and salvage of the left eye by chemotherapy and radiotherapy, the patient 11 years after of first episode, presented metastasis in the distal end of the right radius, performing neoadjuvant and subsequent wide oncological resection with healthy margins of the distal end of the radius plus reconstruction with the ipsilateral proximal end of the fibula and wrist arthrodesis.

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Predictive factors of invasion in eyes with retinoblastoma enucleated after eye salvage treatments

Balaguer¹,

Wilson²,

Billups³

et al. 2009

Pediatric Blood & Cancer

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Background The impact of chemotherapy, focal therapies, radiation and co-existing ocular morbidities on histology of eyes with retinoblastoma enucleated following chemoreduction is not well known. Procedure 25 eyes (23 patients) with retinoblastoma enucleated after failing eye-salvage therapy were evaluated. Reasons for enucleation (tumor progression, subretinal or vitreous seeds) and co-morbid conditions (neovascular glaucoma, cataract, vitreous hemorrhage and retinal detachment) were documented. All specimens were reviewed for evidence of ciliary body, choroidal, optic nerve, and scleral invasion. Results The median age at diagnosis was 14 months (range, 1 to 37 months). Twenty eyes were classified as Reese-Ellsworth Group IV-V at diagnosis. Twenty-four eyes had recurrent disease at enucleation; one eye was enucleated for neovascular glaucoma and vitreous hemorrhage. Co-existing ocular morbidities at enucleation included vitreous hemorrhage (n=6), retinal detachment (n=9), neovascular glaucoma (n=9) and cataracts (n=3). Histologic findings included choroidal invasion (n=7), ciliary body invasion (n=4), optic nerve invasion (n=6) and scleral invasion (n=3). The median time from diagnosis to enucleation was 11 months. No treatment rendered prior to enucleation significantly increased the likelihood of invasion. However, co-existing retinal detachment and vitreous hemorrhage significantly increased the likelihood of optic nerve invasion (p=0.014 and p=0.011, respectively). Prolonged time to enucleation was significantly associated with the likelihood of choroidal (p=0.010) and ciliary body (p=0.021) invasion as well as invasion of multiple sites. Conclusion In eyes with retinoblastoma enucleated after chemoreduction, co-existing ocular morbidities and time to enucleation are predictive of extra-retinal extension.

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Clinicopathologic Factors Related to Metastasis in Retinoblastoma

Cited by 10 publications

References 17 publications

Late and Distant Metastases of Retinoblastoma to Long Bones: A Purpose of a Case

Late and Distant Metastases of Retinoblastoma to Long Bones: A Purpose of a Case

Late and Distant Metastases of Retinoblastoma to Long Bones: A Purpose of a Case

Predictive factors of invasion in eyes with retinoblastoma enucleated after eye salvage treatments

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