Clinicopathologic correlates of giant pituitary adenomas

Chacko, Geeta; Chacko, Ari G; Lombardero, Matilde; Mani, Sunithi; Seshadri, M. S.; Kovács, Kálmán; Scheithauer, Bernd W.

doi:10.1016/j.jocn.2008.08.018

Cited by 35 publications

(24 citation statements)

References 19 publications

(36 reference statements)

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“…1,2 Recently, the endoscopic transsphenoidal technique has been applied as a minimally invasive surgery to remove pituitary adenomas. 3 Most pituitary adenomas are soft and thus can be adequately removed by aspiration and curettage via the transsphenoidal route.…”

mentioning

confidence: 99%

Tumor Consistency of Pituitary Macroadenomas: Predictive Analysis on the Basis of Imaging Features with Contrast-Enhanced 3D FIESTA at 3T

Yamamoto¹,

Kakeda²,

Shimajiri

et al. 2013

American Journal of Neuroradiology

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confidence: 99%

Tumor Consistency of Pituitary Macroadenomas: Predictive Analysis on the Basis of Imaging Features with Contrast-Enhanced 3D FIESTA at 3T

Yamamoto¹,

Kakeda²,

Shimajiri

et al. 2013

American Journal of Neuroradiology

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“…In a group of predominantly non-functioning adenomas, Ki-67 indices ranged from 1% to 4.8% [24] and from 1.4% to 5.2% in somatotropinomas [25]. TOPO 2A-positive immunostaining in our somatotropinomas was higher than that in patients with different types of PAs [11,13], where values of the TOPO 2A index ranged from 0% to 3.5%, with a median value of about 0.7% [13,26], against our median LI of 1.5%.…”

Section: Prace Oryginalnementioning

confidence: 57%

Markery Proliferacji I Inwazyjności W Guzach Przysadki Wydzielających Hormon Wzrostu

Bałdys-Waligórska

Wierzbicka

Sokołowski

et al. 2015

Endokrynologia Polska

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Introduction: In the search for markers of invasiveness of pituitary adenomas, we studied the expression of Ki-67 antigen, TOPO 2A (topoisomerase 2 alpha), AIP (Aryl Hydrocarbon Receptor-Interacting Protein), and VEGF (Vascular Endothelial Growth Factor) in somatotropinomas. Material and methods:We retrospectively studied a group of 31 patients who underwent pituitary tumour surgery. Expression of Ki-67, TOPO 2A, AIP, and VEGF in surgical specimens was determined by immunohistochemistry. Relations between quantitatively determined markers and clinical symptoms, tumour features, and MR imaging, were analysed. Acromegaly was confirmed by hormonal tests in all patients studied. Local invasiveness (cavernous sinus penetration, optic chiasm compression or suprasellar extension) was observed in 18/31 patients (58.1%).

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“…Overall, 68% of them were prolactin-secreting tumors. In contrast, around one-third of the adult pituitary adenomas are non-functioning, and as the size of the tumors increases, percentage of non-functioning tumors rises [4]. The frequency of GH adenomas among the micro-and macroadenomas of children and young patients was reported as 7% in Cannavo's series.…”

Section: Discussionmentioning

confidence: 93%

Pituitary macroadenomas (>3 cm) in young adulthood: Pathologic and proliferative characteristics

Öngürü

Düz²,

Şimşek

et al. 2015

Neurologia i Neurochirurgia Polska

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Clinicopathologic correlates of giant pituitary adenomas

Cited by 35 publications

References 19 publications

Tumor Consistency of Pituitary Macroadenomas: Predictive Analysis on the Basis of Imaging Features with Contrast-Enhanced 3D FIESTA at 3T

Tumor Consistency of Pituitary Macroadenomas: Predictive Analysis on the Basis of Imaging Features with Contrast-Enhanced 3D FIESTA at 3T

Markery Proliferacji I Inwazyjności W Guzach Przysadki Wydzielających Hormon Wzrostu

Pituitary macroadenomas (>3 cm) in young adulthood: Pathologic and proliferative characteristics

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