Clinicopathologic Characteristics and Treatment Outcomes of Penile Cancer

Nam, Jong Kil; Lee, Dong Hoon; Park, Sung Woo; Kam, Sung Chul; Lee, Ki Soo; Kim, Tae Hyo; Kim, Taek Sang; Oh, Cheol Kyu; Park, Hyun Jun; Kim, Tae Nam

doi:10.5534/wjmh.2017.35.1.28

Cited by 10 publications

(11 citation statements)

References 29 publications

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“…younger males. [10][11][12] In this study, we found it be more common in men above 60 years. Men who are unmarried, divorced or separated are more prone to the disease.…”

Section: Discussionsupporting

confidence: 55%

“…13,14 The disease may occur at any site, however, the glans penis is the most common primary site and well to moderately differentiated squamous cell carcinoma is the most common histological grade. 11,15 Patients In the present study, we compared the SEER stage, AJCC stage, and TNM stage with or without TG to predict the CSM free survival after PTE. Our model showed Our results are comparable to the results of the study conducted by Thuret et al Analyzing their findings, TNM stage (78%) was more accurate than AJCC stage (77.2%) in predicting 5-year CSM free rates.…”

Section: Discussionmentioning

confidence: 99%

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The Prognostic Ability of Staging System in Men with Penile Cancer: An Analysis of SEER Database

et al. 2020

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Background: Penile cancer is now a rare condition. The low incidence of the disease makes a valid estimation of its prognosis difficult. In this study, we made an attempt and propose a nomogram to develop a prognostic rule that could predict the Cancer-Specific Mortality (CSM) free rates in patients with primary penile squalors cell carcinoma of the penis (PPSCC).Methods: This study included 1304 patients diagnosed with PPSCC between the years 2004 & 2011 and treated with penile tumor excision. Subjects were staged as per Surveillance, Epidemiology & End Results stage (SEER), American Joint Committee on Cancer (AJCC), TNM classification and tumor grade (TG). CSM free rates were determined. Univariate and multivariate Cox regression model was used to test the prediction of the CSM free rate. The predictive rule accuracy was created using the receiver operating characteristic curve. Results: The clinico-pathological profile depicts a mean age of 64.66 ± 14.38 yrs. The most common primary site involved was glans penis (n= 483, 37%) and the disease was most commonly diagnosed at AJCC stage I (n= 670, 51.4%) disease. The cumulative 5-year CSM free rates according to Fine & Gray, & Kaplan-Meier methods were 81.8% and 79.8%, respectively. The predictive accuracy as per SEER stage, AJCC stage, TNM stage alone were 68.8%, 70.3%, 72.3%, respectively. When TG was combined, the predictive accuracy increased to 72.8%, 73.1%, and 75.0%, respectively. TNM stage with TG was most accurate in predicting CSM free rate compared to other models. Conclusions: TNM stage with TG and AJCC stage with TG appear to have comparable accuracy to predict the CSM free rate in patients with PPSCC, the TNM stage with TG is the most accurate (75%) method to predict the CSM free rates. The addition of the TG variable improved the accuracy of these prognostic models.

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“…younger males. [10][11][12] In this study, we found it be more common in men above 60 years. Men who are unmarried, divorced or separated are more prone to the disease.…”

Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

The Prognostic Ability of Staging System in Men with Penile Cancer: An Analysis of SEER Database

et al. 2020

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“…Aita et al claimed that high histopathological grade was responsible for a poor prognosis based on a study with an average follow-up more than 3 years involving 163 PC patients [30]. Other studies also emphasized the importance of pathologic grade [31,32]. But, in our study, it seemed that the histopathological grade played a different role in the assessment of patients' prognosis except for the grade III.…”

Section: Discussioncontrasting

confidence: 53%

Prognostic Nomogram for Penile Cancer, an Analysis Based on SEER Database

Gao

Tang

Guo

et al. 2020

Preprint

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Background: We aimed to establish a prognostic nomogram for Penile Cancer (PC) patients based on the Surveillance, Epidemiology, and End Results Program (SEER) database.Methods: Data of 1694 patients between 2010 and 2015 were downloaded and extracted from the SEER database. Then, they were randomly divided into the development group (70%) and the verification group (30%). Following, the univariate and multivariate Cox proportional hazards regression was respectively used to explore the possible risk factors of PC. Factors which significantly related to the overall survival (OS) were used to establish the nomogram. Further, the concordance index (C-index), receiver operating characteristic curve (ROC) and calibration curve were used to assess the nomogram, respectively. An internal validation was carried out to test the accuracy and effectiveness of nomogram. Finally, the Kaplan-Meier calculation was used to predict the further survival status of these patients.Results: Multivariate Cox proportional hazards regression demonstrated that the independent prognostic risk factors associated with PC were age, stage T, N and M, and grade, with a moderate c-index of 0.732 [95% confidence interval (CI), 0.706-0.757] in development group and 0.743 (95% CI, 0.703-0.782) in verification group. Meanwhile, the areas under the ROC (AUC) of 3-year and 5-year survival were 0.739 and 0.727, respectively. The survival calibration curves of 3-year and 5-year brought out a high consistency. Conclusion: Our study obtained a satisfactory nomogram to reveal the survival of PC patients, which could be helpful for clinicians to assess the situation of PC patients and to implement the further treatment.

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“…This is the most frequent histological type, other histological forms are rare. Nam et al [15] reported 2 cases of leiomyosarcoma, a penile location of a large B-cell non-Hodgkin's lymphoma was described in the series of Sow et al [9]. Squamous cell carcinoma of the penis has a slow progression, first locally, then secondarily regionally by invasion of the inguinal lymph nodes, and finally the pelvic lymph nodes.…”

Section: Discussionmentioning

confidence: 99%

Cancer of the Penis: Clinical Features and Therapeutic Modalities in Senegalese Hospitals

Thiam¹,

Sarr²,

Sow³

et al. 2020

IJCU

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Background: Penile cancer is a rare malignancy in Senegal. This rarity is probably related to the fact that circumcision, which has a protective effect, is a common practice in childhood. Some of the known risk factors include uncircumcised status, chronic inflammatory conditions, and a history of condyloma acuminata, smoking, and possibly human papillomavirus exposure. It is a pathology in adults with a maximum incidence after the age of 50. In our practice penile cancer is most often diagnosed at an advanced stage or only a radical and mutilating treatment may be proposed. Aims: To describe the clinical and therapeutic features of penis cancer in Senegal. Patients and methods: we carried out a retrospective, descriptive, bicentric study, collecting the records of patients with penis cancer in the Urology-Andrology department of the Aristide Le Dantec University hospital and the military hospital of Ouakam between January 2010 and December 2019. Results: fourteen cases of penile cancer were diagnosed. The mean age was 53.2 years with extremes of 29 and 84 years, the average consultation time was 21 months. All patients were circumcised in childhood. The tumor was limited to the glans in 2 cases and involved the entire penis in 5 cases. Six patients had bilateral inguinal adenopathies. The histological type was squamous cell carcinoma in all cases with a predominance of grade 2 (8 cases). Patients were classified as cT3 (7 cases), cT2 (5 cases), cT4 (1 case) and cT1 (1 case). Treatment consisted of partial amputation of the penis (5 cases), emasculation and perineal urethrostomy (4 cases) total amputation and perineal urethrostomy (2 cases). Three patients had refused total penis amputation. The average length of follow-up was 26 months (4 and 72 months), 3 lymph nodes recurrences and 2 local recurrences were observed. Two patients died among the operated patients. Conclusion: Cancer of the penis is rare in Senegal. The delay in diagnosis explains the frequency of advanced forms which can only be treated by radical surgery.

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Clinicopathologic Characteristics and Treatment Outcomes of Penile Cancer

Cited by 10 publications

References 29 publications

The Prognostic Ability of Staging System in Men with Penile Cancer: An Analysis of SEER Database

The Prognostic Ability of Staging System in Men with Penile Cancer: An Analysis of SEER Database

Prognostic Nomogram for Penile Cancer, an Analysis Based on SEER Database

Cancer of the Penis: Clinical Features and Therapeutic Modalities in Senegalese Hospitals

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