Clinicopathologic characteristics and survival outcomes of primary mucosal melanomas: A 10-year retrospective analysis from a single tertiary medical center in Thailand

Aiempanakit, Kumpol; Chiratikarnwong, Kanokphorn; Auepemkiate, Sauvarat; Sriplung, Hutcha

doi:10.1016/j.dsi.2017.12.004

Cited by 2 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to their anatomical location, mucosal melanomas are often diagnosed at an advanced stage, contributing to their aggressive phenotypes and dismal prognosis (95,96). Compared with cutaneous melanomas, mucosal melanomas present more aggressive characteristics, including advanced TNM stage at diagnosis, high growth rate, and high metastatic potential (97,98).…”

Section: Mucosal Melanoma Clinicopathological Characteristics and Patient Survivalmentioning

confidence: 99%

Immunotherapy in Acral and Mucosal Melanoma: Current Status and Future Directions

Mao

Zhang

et al. 2021

Front. Immunol.

View full text Add to dashboard Cite

Acral and mucosal melanomas are extremely rare in Caucasians; however, they are the predominant melanoma subtypes in Asians and other non-Caucasian populations. Acral and mucosal melanomas share many clinicopathological features, including aggressive phenotypes, similar genetic landscapes, and grim prognoses. In spite of advances in melanoma management, patients with acral and mucosal melanomas show limited benefit from current therapies. The rarity of these subtypes of melanoma is a significant factor contributing to the poor understanding of these pathological subtypes and the lack of effective interventions. Furthermore, the mechanisms contributing to disparities between different types of melanoma remain largely unclear. Herein, we comprehensively review current knowledge on the clinicopathological characteristics and mutational landscapes of acral and mucosal melanomas, as well as providing an overview of current therapies for patients with these aggressive melanoma subtypes, focusing on available immunotherapeutic interventions. We also discuss pathological differences between different melanoma subtypes and summarize current knowledge on melanoma disparities between Asians and Caucasians. Finally, we discuss emerging immunotherapeutic strategies for the treatment of acral and mucosal melanomas, focusing on combination therapies with immune checkpoint inhibitors. Unraveling the unique features of acral and mucosal melanomas is key for their early diagnosis and for the development of effective therapies.

show abstract

Section: Mucosal Melanoma Clinicopathological Characteristics and Patient Survivalmentioning

confidence: 99%

Immunotherapy in Acral and Mucosal Melanoma: Current Status and Future Directions

Mao

Zhang

et al. 2021

Front. Immunol.

View full text Add to dashboard Cite

show abstract

Treatment of acral and mucosal melanoma: Current and emerging targeted therapies

Zhang,

Tian,

Mao

et al. 2024

Critical Reviews in Oncology/Hematology

View full text Add to dashboard Cite

Clinicopathologic characteristics and survival outcomes of primary mucosal melanomas: A 10-year retrospective analysis from a single tertiary medical center in Thailand

Cited by 2 publications

References 13 publications

Immunotherapy in Acral and Mucosal Melanoma: Current Status and Future Directions

Immunotherapy in Acral and Mucosal Melanoma: Current Status and Future Directions

Treatment of acral and mucosal melanoma: Current and emerging targeted therapies

Contact Info

Product

Resources

About