Clinicopathologic Characteristics and Survival of Patients With Bone Metastasis in Yazd, Iran

Shabani, Masoud; Binesh, Fariba; Behniafard, Nasim; Nasiri, Faezeh; Shamsi, Farimah

doi:10.1097/md.0000000000000317

Cited by 8 publications

(5 citation statements)

References 15 publications

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“…A recent study has shown that patient age (OR = 1.024, p < 0.001), the concentration of neuron-specific enolase (OR = 1.212, p = 0.004), and histopathological types (OR = 0.995, p = 0.001) were the independent risk factors for bone metastasis in patients with lung cancer (Zhou et al, 2017; Niu et al, 2014). Another study has shown that clinical stage, histology, and the clinicopathological characteristics were related to a higher risk of bone metastasis in patients with completely resected non-small-cell lung cancer (NSCLC) (Wang et al, 2017; Oliveira, Mello & Paschoal, 2016; Shabani et al, 2014). The risk factors for bone metastasis in SCLC were not frequently reported and in addition to age, race, gender, and N stage, the tumor size was also a risk factor for bone metastasis.…”

Section: Discussionmentioning

confidence: 99%

Different distant metastasis patterns based on tumor size could be found in extensive-stage small cell lung cancer patients: a large, population-based SEER study

Liu

et al. 2019

PeerJ

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Background Small-cell lung cancer (SCLC) is a malignant cancer with the ability to metastasize quickly. The relationship between tumor size and the distant metastasis patterns of Extensive-Stage Small Cell Lung Cancer (ES-SCLC) has not been reported.ObjectivesThe aim of this study was to determine the different distant metastasis patterns as they related to tumor size in ES-SCLC.Patients and MethodsWe used Surveillance, Epidemiology, and End Results (SEER) population-based data collected from 2010 through 2013 to identify 11058 ES-SCLC patients with definite evidence of distant metastases. Multivariate logistic regression analysis was used to demonstrate the association between tumor size and distant metastasis patterns including bone, liver, brain, and lung metastases. Age, race, sex, and N stage were also selected in the logistic regression model.ResultsSubtle differences in metastasis patterns were found among patients based on different tumor sizes. Patients with tumors 3–7 cm have a higher risk of bone metastasis compared with those that have tumors ≤3 cm (OR 1.165, 95% CI [1.055–1.287], P = 0.003) and patients with tumors ≥7 cm have a higher risk of lung metastasis (OR 1.183, 95% CI [1.039–1.347], P = 0.011). In addition, patients with tumors ≥7 cm had a lower risk of brain metastasis and liver metastasis than patients with tumors ≤3 cm (OR 0.799, 95% CI [0.709–0.901], P < 0.001; OR 0.747, 95% CI [0.672–0.830], P < 0.001). Interestingly, there was no correlation between a larger tumor and a higher risk of metastasis. However, the tumor metastasis pattern did have some correlation with age, gender, race and N-status.ConclusionThe pattern of distant metastasis of ES-SCLC is related to the tumor size and the tumor size is indicative of the metastatic site. Larger tumor sizes did not correlate with a higher risk of distant metastasis, but the size is related to the pattern of distant metastasis. The study of different distant metastasis patterns based on tumor size and other clinical features (e.g., age, race, sex, and N stage) in ES-SCLC is clinically valuable.

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Section: Discussionmentioning

confidence: 99%

Different distant metastasis patterns based on tumor size could be found in extensive-stage small cell lung cancer patients: a large, population-based SEER study

Liu

et al. 2019

PeerJ

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“…Bone metastasis is a common problem in advanced cancer patient. Based on the latest data, an estimate of 50% of patients with bone metastases will undergo poorly controlled pain during the course of their disease, 1 , 2 which affects sleep, diet, emotion, and daily activities, with quality of life severely impaired. 3 The current management for bone metastasis are primarily palliative, especially for patients with extensive disease involving multiple bone metastatic sites, a systemic approach including chemotherapy, hormonal therapy, bisphosphonates, and radiopharmaceuticals, is used.…”

Section: Introductionmentioning

confidence: 99%

125I Seed Implant Brachytherapy for Painful Bone Metastases After Failure of External Beam Radiation Therapy

et al. 2015

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The purpose of this study was to evaluate the safety and therapeutic efficacy of computed tomography (CT)-guided 125I seed implant brachytherapy in patients with painful metastatic bone lesions after failure of external beam radiation therapy (EBRT).From August 2012 to July 2014, 26 patients with painful bone metastases after failure of EBRT were treated with CT-guided 125I seed implant brachytherapy. Patient pain and analgesic use were measured using the Brief Pain Inventory before treatment, weekly for 4 weeks, and every 4 weeks thereafter for a total of 24 weeks. Opioid analgesic medications and complications were monitored at the same follow-up intervals.Before 125I seed implantation, the mean score for worst pain in a 24-hour period was 7.3 out of 10. Following treatment, at weeks 1, 4, 8, 12, and 24, worst pain decreased to 5.0 (P < 0.0001), 3.0 (P < 0.0001), 2.8 (P < 0.0001), 2.6 (P < 0.0001), and 2.0 (P = 0.0001), respectively. Opioid usage significantly decreased at weeks 4, 8, and 12. Overall response rates of osseous metastases after 125I seed implantation at 1, 4, 8, 12, and 24 weeks were 58%, 79%, 81%, 82%, and 80%, respectively. Adverse events were seen in 4 patients, including Grade 1 myelosuppression and Grade 1 late skin toxicity.125I seed brachytherapy is a safe and effective treatment for patients with painful bone metastases after failure of EBRT.

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“…Spinal metastases are common in patients with advanced cancer, second only to lung and liver metastases in incidence [27] . Pain is the most common complication in patients with bone metastases [28] , poorly controlled in half of them [29][30] , which seriously affects quality of life [31] . Traditional treatments for pain related to cancer include surgery, radiation, and chemotherapy, with the goal of reducing or eliminating the cause of pain.…”

Section: Discussionmentioning

confidence: 99%

The efficacy and safety of CT-guided 125I seed implantation by coplanar template as a salvage therapy for vertebral metastases after failure of external beam radiation therapy: a retrospective study

Man

Bai

et al. 2023

Preprint

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Purpose To evaluate the efficacy and safety of computed tomography (CT)-guided 125I seed implantation by coplanar template for vertebral metastases after failure of external beam radiation therapy. We also want to compare the dosimetry of 3D printed coplanar template-assisted interstitial 125I brachytherapy preoperative and postoperative, and to explore the accuracy of this technology. Material and methods We retrospectively collected and analyzedthe results of 56 patients with vertebral metastases after failure of external beam radiation therapy, who underwent interstitial 125I brachytherapy as a salvage treatment with a CT-guided coplanar template-assisted technique from January 2015 to January 2017. Results The NRS score for worst pain was 6.1 ± 1.1 before 125I seed implantation. The mean posto-perative NRS score decreased significantly at T4w (3.5 ± 0.9, p < 0.01), T8w (2.1 ± 0.9, p < 0.01), T12w (1.5 ± 0.7, p < 0.01) and T6m (1.2 ± 0.6, p < 0.01) respectively. There was no significant difference in scores among T0, T24h (P = 0.10) and T1w (P = 0.09). The local control rates after 3, 6, 9 and 12 months were 100% (58/58), 92.5% (49/53), 90.2% (46/51), and 85.1% (40/47), respectively. By performing paired t-test analysis, there were no significant differences in D90, D100, V90, V100, V150, V200, GTV volume, CI, EI and HI between preoperative and postoperative(p༞0.05). Postoperative D90 was an independent influencing factor of local control time (HR: 1.047, 95% CI: 0.998–1.098, p = 0.043). The optimal Cut-off value of postoperative D90 was 130 Gy. Conclusions Interstitial 125I seed implantation can be used as a salvage treatment forpatients with vertebral metastases after failure of external beam radiation therapy. With the auxiliary function of 3D printed coplanar template, the main dosimetry parameters verified after the operation can meet the requirements of the preoperative plan with good treatment accuracy.

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Clinicopathologic Characteristics and Survival of Patients With Bone Metastasis in Yazd, Iran

Cited by 8 publications

References 15 publications

Different distant metastasis patterns based on tumor size could be found in extensive-stage small cell lung cancer patients: a large, population-based SEER study

Different distant metastasis patterns based on tumor size could be found in extensive-stage small cell lung cancer patients: a large, population-based SEER study

125I Seed Implant Brachytherapy for Painful Bone Metastases After Failure of External Beam Radiation Therapy

The efficacy and safety of CT-guided 125I seed implantation by coplanar template as a salvage therapy for vertebral metastases after failure of external beam radiation therapy: a retrospective study

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