Clinicopathologic characteristics and outcomes of patients with mycosis fungoides

Alghubaywi, Faisal A; Alharthi, Sawsan A; Aldharman, Sarah S; Najjar, Raneem H; Aleissa, Majed Y; Aljarbou, Ohoud Z; AlJasser, Mohammed I.; Almohideb, Mohammad

doi:10.15537/smj.2023.44.4.20220860

Cited by 2 publications

(5 citation statements)

References 24 publications

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“…13 On immunohistology, the neoplastic T cells had CD4-positive/CD8-positive phenotype with a predominance of CD8. 13 Therapy consisted of topical corticosteroids. Table 1 summarizes these previous studies.…”

Section: Mycosis Fungoides In Saudi Arabiamentioning

confidence: 96%

“…There was a delay in the diagnosis of MF because some of the patients were initially misdiagnosed with chronic dermatitis. This may be reasoned to the fact that MF and chronic dermatitis can have overlapping clinical manifestations 13 . On immunohistology, the neoplastic T cells had CD4‐positive/CD8‐positive phenotype with a predominance of CD8 13 .…”

Section: Introductionmentioning

confidence: 99%

“…This may be reasoned to the fact that MF and chronic dermatitis can have overlapping clinical manifestations 13 . On immunohistology, the neoplastic T cells had CD4‐positive/CD8‐positive phenotype with a predominance of CD8 13 . Therapy consisted of topical corticosteroids.…”

Section: Introductionmentioning

confidence: 99%

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Folliculotropic mycosis fungoides associated with follicular mucinosis: A case report and mini review

Aldayhum,

Alshahrani,

Hussein

et al. 2024

Clinical Case Reports

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Key Clinical MessageF‐MF is a rare non‐classic variant of MF. In the case of hair loss, this should be a diagnostic consideration. The essence of the diagnosis of F‐MF is a careful medical history, physical examination, and a combination of immunohistological and molecular analyses (Cureus. 2022; 14:e21231, Ann Saudi Med. 2012; 32:283, Oman Med J. 2012; 27:134, Int J Dermatol. 2016; 55:1396, Saudi Med J. 2018; 39:994 and Case Rep Oncol. 2018; 11:436).AbstractMycosis fungoides (MF) is a primary cutaneous T‐cell lymphoma with multiple subtypes. Follicular MF (F‐MF) is a non‐classic variant of MF. Histological features entail folliculotropism and damage of the epithelium lining of the hair follicles with or without mucin deposition. A 52‐year‐old male patient complained of recurrent skin lesions on the scalp over 8 months. The lesions appeared suddenly, enlarged over time, and became itchy. A skin punch biopsy was performed. Histological features included mucin deposits in the epithelium of the hair follicles and dense, predominantly perifollicular atypical lymphocytes infiltrating the follicular epithelium. The lymphoid cells were composed of CD3‐positive T cells (CD4/CD8‐positive T cells) with a shift in favor of the former. The case was diagnosed as F‐MF on an immunohistological basis. The diagnosis of F‐MF is often difficult for dermatologists and dermatopathologists alike. Not only clinicopathological correlations but also immunohistochemical and molecular analysis are required.

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Section: Mycosis Fungoides In Saudi Arabiamentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Folliculotropic mycosis fungoides associated with follicular mucinosis: A case report and mini review

Aldayhum,

Alshahrani,

Hussein

et al. 2024

Clinical Case Reports

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“…Lesions could mimic benign inflammatory dermatoses, including but not limited to eczema, pigmented purpuric dermatosis, psoriasis, and lichen planus (LP). Besides, several peculiar new variants have been described to date; follicular, hypopigmented, and ichthyosiform MF, to name a few 1–3 . All these can pose a diagnostic pitfall to dermatologists.…”

Section: Introductionmentioning

confidence: 99%

“…Besides, several peculiar new variants have been described to date; follicular, hypopigmented, and ichthyosiform MF, to name a few. 1 , 2 , 3 All these can pose a diagnostic pitfall to dermatologists. Herein, we report a case with a rare variant of lichenoid MF subjected to multiple histopathological assessments.…”

Section: Introductionmentioning

confidence: 99%

Lichenoid mycosis fungoides: Report of a case with lichen planus‐like histopathologic features

Kianfar,

Ghanadan,

Aryanian

et al. 2023

Clinical Case Reports

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Key Clinical MessageMycosis fungoides is a diagnostic challenge. Herein, we report a case with marked lichenoid features in pathology assessments. After several biopsies and clinicopathologic correlation, the diagnosis of lichenoid mycosis fungoides was made.AbstractMycosis fungoides (MF) is a great imitator and mimicks other dermatoses clinically and histopathologically. We report a 61‐year‐old patient with 5‐year history of generalized violaceous patches and plaques. His biopsy revealed a marked lichenoid band‐like infiltrate of inflammatory cells along the basal layer with basal layer vacuolar changes; the diagnosis of lichen planus was first made histopathologically. Several biopsy specimens, clinicopathologic correlation, and immunohistochemistry findings confirmed the diagnosis of lichenoid MF. Awareness of peculiar histopathologic findings of MF is essential to avoid a potential misdiagnosis. When in doubt, multiple biopsies with other diagnostic methods should be employed.

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Clinicopathologic characteristics and outcomes of patients with mycosis fungoides

Cited by 2 publications

References 24 publications

Folliculotropic mycosis fungoides associated with follicular mucinosis: A case report and mini review

Folliculotropic mycosis fungoides associated with follicular mucinosis: A case report and mini review

Lichenoid mycosis fungoides: Report of a case with lichen planus‐like histopathologic features

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