Clinicopathologic and prognostic significance of the expression of mucins, simple mucin antigens and histoblood group antigens in papillary thyroid carcinoma

Alves, Pedro; Soares, Paula; Rossi, Símone; Fonseca, Elsa; Sobrinho‐Simöes, Manuel

doi:10.1007/bf02739773

Cited by 6 publications

(5 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Intracellular mucin in their PTC cases had the same sharply delineated vacuoles with homogeneous eo-sinophilic inclusion bodies as we have described. Alves et al described positive immunohistochemical expression of mucin antigens (MUC1, MUC2) in a high percentage (73%) of PTC cases, but they could not directly correlate their presence with biologic aggressiveness (12).…”

Section: Discussionmentioning

confidence: 98%

Aspiration Cytopathology of Metastatic Mucinous Papillary Thyroid Carcinoma

Morrison

Wakely

2001

Modern Pathology

View full text Add to dashboard Cite

The light microscopic histopathology and cytopathology of papillary thyroid carcinoma (PTC) and its variants is amply depicted in reviews, books, and book chapters. One of the changes in PTC, however, that is infrequently discussed or illustrated in the literature is that of mucinous metaplasia. In the aspiration cytopathology literature, we are aware of only a rare report of PTC exhibiting extensive mucinous metaplasia. We present an example correlating the histopathology and fine needle aspiration cytopathology of a PTC that had metastasized on several separate occasions to cervical lymph nodes, and in the process demonstrated mucinous trans- The presence of mucin in endocrine neoplasms is an unexpected finding in contrast to its frequent production in non-endocrine epithelial tumors. This can assume diagnostic importance if the pathologist is asked to determine the site of a mucin-producing metastatic carcinoma in a patient with either an unknown primary or a remote history of cancer. Almost four decades ago, in a large study of the surgical pathology of various metastatic neoplasms (including 93 examples of thyroid cancer), Foster et al. concluded that "the thyroid is the only site studied that can be ruled out with great assurance when one is dealing with a mucicarmine positive metastasis" (1). Although reports to the contrary have been published (2-4), our impression is that many pathologists remain under the misconception that carcinomas of the thyroid are nearly all mucin-negative. This assumption from histopathology has been transferred to fine needle aspiration (FNA) cytopathology of thyroid carcinoma, where only rare descriptions or illustrations of extracellular mucin or mucin-filled vacuoles exist (5, 6). The aim of this article is to illustrate and describe the FNA cytopathology (and corresponding histopathology) of a mucinous papillary thyroid carcinoma (PTC) and to discuss the potential pitfalls related to this phenomenon. CASE REPORTA 66-year-old man had undergone complete thyroidectomy at an outside hospital for PTC 10 years earlier after an initial right cervical lymph node biopsy revealed metastatic disease. Over the past decade, he has received three courses of radioactive iodine therapy and has had two separate surgical procedures to excise repeatedly enlarged right neck lymph nodes. On each occasion these nodes contained metastatic PTC both within the node proper and in extranodal soft tissue. No metastasis beyond the right cervical lymph node group has ever been detected.He presented to our medical center because of a third recurrence of right cervical lymphadenopathy since his initial thyroidectomy. FNA biopsy of an enlarged right cervical lymph node was performed and revealed metastatic carcinoma. Subsequent surgical resection of the aspirated node and surrounding soft tissue was performed 2 weeks after FNA confirmed that diagnosis. One year after the FNA, he presented with a fourth recurrence of a right neck mass. This was excised without performing another prior FNA, and again it reve...

show abstract

Section: Discussionmentioning

confidence: 98%

Aspiration Cytopathology of Metastatic Mucinous Papillary Thyroid Carcinoma

Morrison

Wakely

2001

Modern Pathology

View full text Add to dashboard Cite

show abstract

“…Furthermore, it was successively reported underglycosylated MUC1 expression in papillary thyroid carcinomas that suggested the presumptive role of a defective glycosylation pathway of MUC1 leading to the accumulation of acid molecules in the apical membranes of the tumor cells. 24,29…”

Section: Discussionmentioning

confidence: 99%

“…6,23 Mucin alterations may influence the invasive and metastatic properties of neoplastic cells by changing cancer cell growth regulation, immune recognition, and cell adhesion. 28,29 However, treatment and clinical prognosis of follicular thyroid neoplasms producing extracellular mucin deposits are not different to that of their more typical thyroid counterpart. Nowadays, the clinical course and therapeutic management of these tumors is determined by their basic histologic nature -absence or presence and extension of unequivocal capsular and/or vascular invasion- rather than cytoplasmic clearing and/or myxoid stromal change.…”

Section: Discussionmentioning

confidence: 99%

Mucinous Variant of Follicular Carcinoma of the Thyroid Gland

Squillaci¹,

Pitino

Spairani

et al. 2015

Int J Surg Pathol

View full text Add to dashboard Cite

The rare reports of mucinous variant of follicular carcinoma of the thyroid gland have not provided enough evidence to support the recognition of these tumors as a distinct clinicopathologic entity or to understand their etiopathogenesis. We report the fourth case of mucinous variant of follicular carcinoma displaying a minimally invasive tumor with diffuse expression of thyroglobulin, TTF-1, CD56, PAX-8, cytokeratins 7 and 19, in the absence of monoclonal carcinoembryonic antigen (CEA), cytokeratin 20, chromogranin, HBME-1, P63 expression, and BRAF gene mutation, in a 51-year-old woman who is alive without signs of disease 13 months after total thyroidectomy, bilateral neck dissection, and radioactive iodine. Herein, fine-needle aspiration cytology disclosed "worrisome" cytologic features consisting of large epithelial cells arranged in clusters or singularly, with high nucleocytoplasmic ratio, nuclear grooves and evident nucleoli which were shared by those of mucin-producing papillary thyroid carcinoma. Therefore, knowledge of the cytological and histopathological spectrum of this lesion is important to avoid misdiagnosis. The morphologic clues leading to the correct diagnosis of mucinous variant of follicular neoplasm have been correlated with the data of the literature, and the differential diagnosis is briefly discussed.

show abstract

“…MUC1, a transmembrane mucin glycoprotein, is a key modulator of several signaling pathways that affect oncogenesis, motility and metastasis . In addition, its expression is closely associated with poor prognosis in patients with several types of malignancies . Recent investigations have found that MUC1 regulates growth factors such as transforming growth factor and platelet‐derived growth factor, both of which are well documented to accelerate cell cycle progression, the cadherin switch, stress kinase‐mediated snail induction and extracellular matrix remodeling in cancer cells .…”

Section: Discussionmentioning

confidence: 99%

“…(22)(23)(24)(25) In addition, its expression is closely associated with poor prognosis in patients with several types of malignancies. (22,26,27) Recent investigations have found that MUC1 regulates growth factors such as transforming growth factor and platelet-derived growth factor, both of which are well documented to accelerate cell cycle progression, the cadherin switch, stress kinase-mediated snail induction and extracellular matrix remodeling in cancer cells. (16,28,29) MUC1 is a transmembrane mucin expressed at the apical surface and affects cell polarity by cooperation with b-catenin at the apical-lateral membrane and epidermal growth factor receptor at the basolateral membrane.…”

Section: Discussionmentioning

confidence: 99%

ALKBH2, a novel AlkB homologue, contributes to human bladder cancer progression by regulating MUC1 expression

et al. 2013

View full text Add to dashboard Cite

The ALKBH family of proteins are highly expressed in various types of human cancer where they are involved in tumor growth and progression. However, multiple isoforms of ALKBH exist and the effect of individual isoforms on the development of urinary bladder cancer is unknown, particularly the molecular mechanisms involved in the progression from a noninvasive to invasive phenotype. We examined the role and function of ALKBH2 in human bladder cancer development in vitro and provide the first report that suppression of ALKBH2 in a human urothelial carcinoma cell line, KU7, reduces the expression of the transmembrane mucin protein, MUC1, and induces G1 cell cycle arrest. Moreover, reduction of ALKBH2 suppressed epithelial to mesenchymal transition (EMT) via increasing E-cadherin and decreasing vimentin expression. Transfection of MUC1 siRNA inhibited cell proliferation and EMT to the same extent as ALKBH2 gene silencing in vitro. ALKBH2 knockdown significantly suppressed MUC1 expression and tumor volume of bladder cancers in vivo as assessed in an orthotopic mouse model using ALKBH2 shRNA transfected KU7 cells. Immunohistochemical examination showed high expression levels of ALKBH2 in human urothelial carcinoma samples, especially in high-grade, superficially and deeply invasive carcinomas (pT(1) and >pT(2)), and in carcinoma in situ but not in normal urothelium. This study demonstrates that ALKBH2 is an upstream molecule of the oncoprotein, MUC1, and regulates cell cycle and EMT, resulting in progression of urothelial carcinomas. (Cancer Sci 2013; 104: 321-327) U rinary bladder cancer is a common cancer of the urogenital system. In 2006, it was estimated that 16 510 new patients were found with bladder cancer, with 6804 projected deaths from the disease in Japan.(1) Urinary bladder cancer is characterized by frequent recurrence and progression that invades the muscularis propria. The role of alterations in molecular pathways that control normal cellular homeostasis in the oncogenesis of bladder cancer is well established.(2) The most common histological type of bladder cancer is urothelial carcinoma. Approximately 80% of patients with urothelial carcinoma present with nonmuscular invasive urothelial carcinoma (from noninvasive papillary to superficially invasive phenotype). Superficially-invasive non-muscular-invasive urothelial carcinoma is notorious for its tendency to invade the muscular layer when it is left untreated, but rarely progress to muscular invasive life-threatening cancer when patients undergo medical treatment. In contrast, muscular invasive urothelial carcinoma and high-grade carcinoma in situ exhibit aggressive behavior with a tendency to develop distal metastatic disease and seem highly resistant to immunotherapy as an initial treatment for bladder cancer as well as surgical intervention and chemoradiation therapy for advanced phenotypes. These two different types of cancer harbor different genetic and molecular alterations.(2,3) Low-grade noninvasive urothelial carcinomas exhibit constitutiv...

show abstract

Clinicopathologic and prognostic significance of the expression of mucins, simple mucin antigens and histoblood group antigens in papillary thyroid carcinoma

Cited by 6 publications

References 23 publications

Aspiration Cytopathology of Metastatic Mucinous Papillary Thyroid Carcinoma

Aspiration Cytopathology of Metastatic Mucinous Papillary Thyroid Carcinoma

Mucinous Variant of Follicular Carcinoma of the Thyroid Gland

ALKBH2, a novel AlkB homologue, contributes to human bladder cancer progression by regulating MUC1 expression

Contact Info

Product

Resources

About