“…Downregulation of pIgR expression is a common feature of adenocarcinomas originating from mucosal tissues, including the colon (Poger et al, 1976;Rognum et al, 1980Rognum et al, , 1982Isaacson, 1982b;Arends et al, 1984;Wiggers et al, 1988;Koretz et al, 1994;Krajci et al, 1996;Traicoff et al, 2003), esophagus (Gologan et al, 2008), and lung (Harris and South, 1981;Brooks and Ernst, 1984;Espinoza et al, 1984;Loosli and Hurlimann, 1984;Kodama et al, 1985;Kondi-Paphitis and Addis, 1986;Popper et al, 1987;Kawai et al, 1988;Ordonez, 1989;Hirata et al, 1990;Ishida et al, 1990a,b;Brown et al, 1993;Khattar et al, 2005;Ocak et al, 2012). Two studies using microarray analysis to identify gene expression biomarkers for colorectal cancer reported that decreased pIgR mRNA levels in metastatic tumors (Jorissen et al, 2009) and colonic biopsies (Agesen et al, 2012) were associated with poor prognosis.…”