Clinicohistopathological Profile of Nasal and Sinonasal Lesions: A Study From Central India

Abstract

Background: Nasal and sinonasal lesions comprise common as well as rarest rare lesions. This region being a site of histopathologically diverse lesions, interests pathologists.
 Objectives: The study aimed to find out incidence of nasal and sinonasal lesion with frequency of non-neoplastic, neoplastic lesions, to study spectrum of lesions histopathologically along with correlation of clinical and radiology findings.
 Material and methods: It was a 2 year retrospective observational study involving 102 cases from January 2012 to December 2013 carried out at Government medical college, Nagpur.
 Study included all specimens received as nasal and sinonasal lesions. Complete clinical history and radiological findings were correlated with histopathology findings.
 Results: Nasal and sinonasal lesions are rare having 1.07 % incidence rate. Majority of patients of nonneoplastic and benign neoplastic category belonged to 11-20 age group while malignancies were common in 41-50 age group. We encountered more neoplastic lesions (53.92%) compared to nonneoplastic lesion (46.08%). Male to female ratio was 1.5:1. Sensitivity, specificity and diagnostic accuracy of clinical diagnosis was 94.73%, 97.67 % and 96 % respectively while positive predictive value and negative predictive value was 98.18 % and 93.33 %. p value was 0.317. Discordance in clinic-histopathological diagnosis was in 5.88 %
 Conclusion: Though there was good correlation between clinicoradiology findings and histopathology, however in 5.88% discordant cases histopathology diagnosis led to significant alteration of treatment plan proving key role of histopathology diagnosis.
 Keywords: Benign, Central India, Clinicohistopathology, Profile, Malignant, Nasal, Sinonasal.

The Prevalence of upper respiratory tract lesions in pathology department, Beni-Suef University Hospital ( Histopathological and immunohistochemical Evaluation )

“…Parallel to our results, Pushpalatha et al, [7] demonstrated that 55 out of 85 nasal polyps were allergic type (68.75%). Other studies showed variable results, Jaison et al, [8] and Khade et al, [9] found that nonallergic type was 28 out of 50 (56%) and 33 out of 41 (80.4%), respectively.…”

“…As regarding the relation between younger age categories and nasal polyps, it was significant (p=0.042). Also, Khade et al, [9], reported 38.3% of 41 patients of nasal polyps belonged to 20-50 age group. However, We et al, [14] found that increasing trend of nasal polyps prevalence with increasing age was statistically significant (p-value> 0.001).…”