Clinicohistopathologic Comparison of Adult Type and Juvenile Type Xanthogranulomas in Korea

Abstract

Xanthogranuloma (XG) is an uncommon benign disorder characterized by solitary or multiple yellow-red papulonodules on the skin, and occasionally, in other organs. It is predominantly a disease of infancy or early childhood, although adults may rarely be affected. To compare the clinicohistopathological featues of juvenile-type xanthogranulomas UXGs) and adult-type xanthogranulomas (AXGs) (>14 years) in Korea, 30 cases of JXGs and 15 cases of AXGs were compared clinically and histopathologically. Except for the fact AXGs were more often solitary and larger and showed neither other associated systemic diseases nor spontaneous regression, the clinical features such as color, mean number, or site of the lesions in AXGs were not statistically different from JXGs. Histologically, AXCs were not significantly different in amounts of foamy cells, giant cells including Touton cells, and inflammatory cells, although subcutaneous involvement was seen only in the two infant cases. In conclusion, in contrast to AXGs, JXGs need special attention to accompanying systemic diseases and do not need excisional procedures, considering their frequent spontaneous regression.

Multiple Adult Xanthogranuloma: Case Report and Literature Review

“…The case reported by Gartmann and Tritsch [9 ]was not retained either because the condition started at the age of 3. Cases described in Chang et al [4] and Gartmann and Tritsch [9] could not be included in our evaluation because the reported data were incomplete [4, 11]. Reviewing the literature, we note that MAXG appears most commonly in men (1.6 male/1 female).…”

“…In JXG, multiple lesions are observed in 12–47% of cases versus 11–30% in AXG [4, 15]. Dehner [16] published the largest series of JXG (174 cases) including patients from birth to the age of 20.…”

“…Occasionally (10% of cases), visceral or mucosal lesions are present (bone, spleen, lung, liver, testicle or eye with a risk of glaucoma). JXG regresses spontaneously during the first few years (3–6 years), sometimes leaving residual pigmentation and atrophy [3,4,5,6]. Histologic examination initially reveals histiocytic proliferation without xanthomatous cells, associated with a moderate infiltrate (lymphoid cells and eosinophils) [3].…”

“…MAXG can be defined according to Chang et al [4 ]by the presence of more than 5 XG lesions. Reviewing the literature, we are able to retrieve 16 cases of MAXG since 1963 including our case (table 1).…”

Adult Type Xanthogranuloma: A Case Report

“…Deri haricinde orbital boşluk, santral sinir sistemi, karaciğer, dalak ve böbrek tutulumu da gözlenebilmektedir (2)(3)(4). Ksantogranuloma genellikle hayatın ilk 3 yılında ve çocuk vakalarda gözlenmekle birlikte, literatürde ender olarak, olgumuzda olduğu gibi erişkin yaşta başlangıç göste-ren olgulara rastlanabilmektedir.…”