Clinicoepidemiological study of murine typhus on the Greek island of Evia

Tselentis, Yannis; Babalis, T.; Chrysanthis, D.; Gikas, Achilleas; Chaliotis, G.; Raoult, Didier

doi:10.1007/bf00144812

Cited by 29 publications

(22 citation statements)

References 15 publications

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“…From the high prevalence of antibodies in northern Greece detected in this study, as in other parts of the country, [9][10][11] it is obvious that Rickettsiae are widely distributed in Greece. This finding confirms the fact that rickettsioses remain a significant health problem in many parts of the world.…”

Section: Discussionmentioning

confidence: 49%

“…6,7 As for Greece, rickettsiosis is thought to be one of the possible causes of the Athenian epidemic of 430-426 BC, which took place at the outbreak of the Peloponnesian War and caused the death of Pericles. 8 In recent years, seroepidemiological surveys conducted in the island of Crete (southern Greece), 9 the province of Fokida (central Greece), 10 and the province of Evia (central Greece) [11][12][13] revealed the presence of antibodies to R. conorii and R. typhi in the population.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of Rickettsia conorii and Rickettsia typhi infections in the population of northern Greece.

Daniel¹,

Manika²,

Arvanmdou³

et al. 2002

The American Journal of Tropical Medicine and Hygiene

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Abstract. Seroepidemical surveys concerning the prevalence of Rickettsia conorii and Rickettsia typhi have never been studied in northern Greece. We examined 1,584 sera samples from residents of northern Greece for the detection of antibodies to R. conorii and to R. typhi by means of immunofluorescence assay. In addition, we compared the prevalence of rickettsial infections among the demographic variables of sex, age, occupation, and area of residence. Antibodies to R. conorii and R. typhi were found in 125 (7.9%) and 31 (2.0%) of the examined subjects, respectively. The prevalence of antibodies to R. conorii correlated with increasing age and was statistically higher in men. Farmers had significantly higher prevalence of antibodies to both species of rickettsiae studied versus other professions. Residents of rural areas showed a statistically higher prevalence for R. conorii versus urban residents, although this difference was not demonstrated for R. typhi. We also detected differences in the prevalence of rickettsial infections among the different prefectures. Our data show the wide distribution of R. conorii in northern Greece and indicate the presence of R. typhi.

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Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 99%

Prevalence of Rickettsia conorii and Rickettsia typhi infections in the population of northern Greece.

Daniel¹,

Manika²,

Arvanmdou³

et al. 2002

The American Journal of Tropical Medicine and Hygiene

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“…[1][2][3][4][5][6][7][8][9][10] The importance of this illness has been underestimated. It is more frequent than is commonly believed and represents a worldwide health problem.…”

mentioning

confidence: 99%

Murine Typhus as a Common Cause of Fever of Intermediate Duration

Bernabéu-Wittel¹,

Pachón²,

Alarcón³

et al. 1999

Arch Intern Med

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Background: Fever of intermediate duration (FID), characterized by a febrile syndrome lasting from 7 to 28 days, is a frequent condition in clinical practice, but its epidemiological and etiologic features are not well described. Murine typhus (MT) is a worldwide illness; nevertheless, to our knowledge, no studies describing its epidemiological and clinical characteristics have been performed in the south of Spain. Also, its significance as a cause of FID is unknown.

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“…In 10 large case series describing 841 patients with murine typhus, rash was found in 59%, but no localized inoculationtype lesions, similar to the one described here, were reported. [4][5][6][7][8][9][10][11][12][13] In a guinea pig model of R. typhi infection, intradermal inoculation of the organism resulted in cutaneous erythema, induration, and necrosis. 18 In another animal model, intended to predict eschar formation following infection with various rickettsial species, R. typhi failed to produce eschars in intradermally inoculated guinea pigs-a finding which the authors state is consistent with what is known clinically of typhus group rickettsioses in humans.…”

Section: Discussionmentioning

confidence: 99%

“…3 The disease presents as an undifferentiated febrile illness accompanied by a maculopapular rash in 59% of infected persons. [4][5][6][7][8][9][10][11][12][13] Unlike many spotted fever group rickettsioses (SFGR) and scrub typhus, infection caused by R. typhi is not associated with an inoculation lesion. We herein describe a patient with murine typhus and an unusual clinical feature at the site of rickettsial inoculation.…”

Section: Introductionmentioning

confidence: 99%