Clinico-Pathological Study of Thyroid Lesions Over a Period of One Year in a Tertiary Care Centre

Gopal, Metta Raja; Rao, Konkena Janardhana; Sai, Adusumalli Ramya

doi:10.14260/jemds/2018/790

Cited by 3 publications

(4 citation statements)

References 17 publications

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“…[17] Fatima et al conducted study on 120 cases, showed peak age of 30-40 years. [18] Gopal MR et al [6] did study on 72 cases of thyroid lesions, maximum number of lesions were seen in patients in the age group of 31 -40 years for thyroid diseases and Islam et al showed the majority of the patients were within 21-40 years of age. [19] In present study among all 50 cases seen, 48 were malignant (96%) and only 2 were Benign (4%).…”

Section: Methodsmentioning

confidence: 99%

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Histopathological Spectrum of Thyroid Neoplasm - A Retrospective Study Done at Tertiary Cancer Care Hospital

Bhandari,

Sharma,

Dipak Nilapwar

2024

Int J Sci Healthcare Res

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Thyroid lesions are fairly common & have a wide spectrum of diseases ranging from functional, immune mediated to neoplastic lesions. All thyroidectomy specimens were included in the study period of 1.5 years from September 2019 to February 2021 at our institute, a total of 10,200 biopsies were sent to our department for histopathological examination, out of which 7200 were diagnosed as malignant cases, of which 408 (5.6%) cases were thyroid cancer (TC) cases. One hundred forty-five (35.53%) out of 408 TC cases underwent thyroid surgeries, fifty consecutive cases who fulfilled the inclusion criteria were registered in our study. All grossed, processed, stained sections of haematoxylin and eosin were reviewed and observed under microscope. Average age of the patients suffering from TC was found 44.80 years. Female preponderance seen with F:M-1.38:1. Most common location of tumor was Right lobe of thyroid (32%) followed by Left Lobe (26%). Malignant lesions (96%) predominated over Benign lesions (4%). Papillary carcinoma thyroid was the most common malignancy (72%) followed by Follicular carcinoma (14%). Both benign cases were of Trabaecular Adenoma (4%). Majority of tumors were Unifocal (62%) followed by Mutlifocal (38%). Keywords: Thyroid Neoplasm, Benign and Malignant lesions

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Section: Methodsmentioning

confidence: 99%

“…Thyroid lesions may be developmental, inflammatory, hyperplastic and neoplastic. [6] About 95% of the TCs happen sporadically and inherited in 55%. As it is a known fact, malignancies arise due to the accumulation of mutations in genes that directly monitor cell growth and death.…”

Section: Introductionmentioning

confidence: 99%

Histopathological Spectrum of Thyroid Neoplasm - A Retrospective Study Done at Tertiary Cancer Care Hospital

Bhandari,

Sharma,

Dipak Nilapwar

2024

Int J Sci Healthcare Res

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“…Thyroid lesions may be developmental, inflammatory, hyperplastic and neoplastic. 4 About 95% of the TC happen sporadically and inherited in 5%. As it is a known fact, malignancies arise due to the accumulation of mutations in genes that directly monitor cell growth and death.…”

Section: Introductionmentioning

confidence: 99%

Galectin-3 and Hector Battifora Mesothelial-1 immunohistochemical expression in 50 cases of thyroid neoplasms: a retrospective study done at tertiary care centre

Bhandari,

Sharma,

Nilapwar

et al. 2024

Int Surg J

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Background: Diagnosis of thyroid carcinoma is not always straight forward on haematoxylin and eosin staining since nuclear features are inconsistent, overlapping and controversial. In regards to this, many studies on the role of immunohistochemical markers for diagnosis of malignant thyroid carcinoma are needed. In order to improve diagnostic accuracy, markers immunohistochemistry techniques have mainly emphasized on galectin-3 (Gal-3) and Hector Battifora Mesothelial-1 (HBME-1). However, results remain unsatisfactory. The aim of the present article was to establish the diagnostic accuracy of Gal-3 and HBME-1 markers, individual and in combination, in the differentiation of malignant and benign thyroid lesions. Methods: A total of 50 thyroidectomy specimens were studied over a period of 1.5 years from September 2019 to February 2021 at Bhagwan Mahaveer Cancer Hospital Research Centre, Jaipur which included 2 benign and 48 malignant thyroid neoplasms. Histopathologic evaluation of H&E stained sections was done and immunohistochemistry (IHC) staining for Gal-3 and HBME-1 was performed for all neoplasms. Results: For the immunohistochemistry technique, Gal-3 and HBME-1expression was significantly higher in malignant thyroid neoplasms in comparison to the benign neoplasms. Gal-3 expression for malignant neoplasms showed sensitivity of 97.92%, specificity of 50%. HBME-1 expression for malignant neoplasms showed sensitivity and specificity of 100% each. Gal-3 and HBME-1 are useful markers in differentiating benign and malignant thyroid neoplasms. Conclusions: This study demonstrated that both immunomarkers studied are sensitive and specific for diagnosis of benign and malignant thyroid lesions. However, the need of further studies for other molecular markers must continue in order to increase the diagnostic accuracy since a proportion of cases still show false-negative and false-positive tests.

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“…12 Variation in age ranges are noticed in different studies as 14-95, 11-89 and 9-70 years 1,11,14 . Majority of the lesions are noticed between the age group of fourth decade [15][16][17] .…”

Section: Introductionmentioning

confidence: 99%

Frequency of Thyroid Lesions at Pathology Department of King Edward Medical University Lahore

Akhtar¹,

Arshad²,

Altaf³

2022

PJMHS

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Background: Thyroid gland is notorious for carrying commonest endocrine pathologies and also for commonest endocrine malignancy. It is the 5th most common cancer in human beings. This makes to carry out current study to get insight of frequency of thyroid lesions at tertiary care level. Methods: This was a descriptive cross-sectional study. The study was done at the Department of Pathology, King Edward Medical University Lahore with the collaboration of four surgical units of Mayo Hospital Lahore from 2010 to 2019. Total 1601 cases were included. Information about age, sex and diagnosis was entered in the pre designed proforma. SPSS version 22 was used for data analysis. Descriptive analysis was done and the results were presented as frequencies, percentages and ratios. The results were then studied against local and international data. Results: This study revealed non neoplastic and neoplastic lesions as 1323 (82.63%) and 278 (17.37%) respectively. Bulk of the lesions 61.6% were between the age bracket of 20-39 years. Mean±SD for age was 34.22±11.42 years. Female to male ratio(F:M) was in favour of females as 9.81:1. Among the non neoplastic lesions, MNG 1151(87%) was a dominant lesion followed by TH 82(6%). LT 29(2.19%) and HT 26(1.96%) were other important lesions. F:M ratio was 10.80:1. Neoplastic lesions were divided into benign 178(64%) and malignant tumors 100(36%). FA was the leading benign neoplasm 164(59%). Rest of the benign tumors shared a minor fraction except HCA 12(4.31%). Among the malignant category, Papillary carcinoma 69(24.82%) dominated over MC 12(4.31%). FC 7(2.51%) and AC 6(2.15%) were other significant findings. F:M ratio in malignancy was 3.16:1 which was significantly lower than 13.83:1 in benign tumors. Conclusion: MNG is the dominant lesion among the non neoplastic lesions while in the neoplastic category FA was leading as benign neoplasm. Papillary carcinoma turned out to be the commonest malignant tumor. Major share of all the lesions were seen between 20-39 years. Keywords: MNG, Papillary carcinoma, Follicular adenoma, neoplastic lesions

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Clinico-Pathological Study of Thyroid Lesions Over a Period of One Year in a Tertiary Care Centre

Cited by 3 publications

References 17 publications

Histopathological Spectrum of Thyroid Neoplasm - A Retrospective Study Done at Tertiary Cancer Care Hospital

Histopathological Spectrum of Thyroid Neoplasm - A Retrospective Study Done at Tertiary Cancer Care Hospital

Galectin-3 and Hector Battifora Mesothelial-1 immunohistochemical expression in 50 cases of thyroid neoplasms: a retrospective study done at tertiary care centre

Frequency of Thyroid Lesions at Pathology Department of King Edward Medical University Lahore

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