Clinico-Pathological Study of 4 Cases of Pseudoherpetic Grover Disease: The Same as Vesicular Grover Disease

Capusan, Tania Marusia; Herrero‐Moyano, M.; Fraga, Javier; Llamas‐Velasco, Mar

doi:10.1097/dad.0000000000001058

Cited by 9 publications

(14 citation statements)

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“…In our series, in three of these patients, histology was suggestive of Grover’s disease, while the others had chickenpox, herpes zoster or Pityrosporum folliculitis. We believe that a proportion of COVID-19-associated skin lesions presenting a papulo-vesicular pattern correspond to the “pseudo-herpetic” variant of Grover’s disease [ 31 , 32 , 33 ]. This is particularly relevant in the differential diagnosis with other viral-induced vesicular lesions.…”

Section: Discussionmentioning

confidence: 99%

Skin Manifestations in COVID-19: Prevalence and Relationship with Disease Severity

Giavedoni

Podlipnik

Pericàs

et al. 2020

JCM

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Background: Data on the clinical patterns and histopathology of SARS-CoV-2 related skin lesions, as well as on their relationship with the severity of COVID-19 are limited. Methods and Materials: Retrospective analysis of a prospectively collected cohort of patients with SARS-CoV-2 infection in a teaching hospital in Barcelona, Spain, from 1 April to 1 May 2020. Clinical, microbiological and therapeutic characteristics, clinicopathological patterns of skin lesions, and direct immunofluorescence and immunohistochemical findings in skin biopsies were analyzed. Results: Fifty-eight out of the 2761 patients (2.1%) either consulting to the emergency room or admitted to the hospital for COVID-19 suspicion during the study period presented COVID-19 related skin lesions. Cutaneous lesions could be categorized into six patterns represented by the acronym “GROUCH”: Generalized maculo-papular (20.7%), Grover’s disease and other papulo-vesicular eruptions (13.8%), livedo Reticularis (6.9%), Other eruptions (22.4%), Urticarial (6.9%), and CHilblain-like (29.3%). Skin biopsies were performed in 72.4%, including direct immunofluorescence in 71.4% and immunohistochemistry in 28.6%. Patients with chilblain-like lesions exhibited a characteristic histology and were significantly younger and presented lower rates of systemic symptoms, radiological lung infiltrates and analytical abnormalities, and hospital and ICU admission compared to the rest of patients. Conclusion: Cutaneous lesions in patients with COVID-19 appear to be relatively rare and varied. Patients with chilblain-like lesions have a characteristic clinicopathological pattern and a less severe presentation of COVID-19.

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Section: Discussionmentioning

confidence: 99%

Skin Manifestations in COVID-19: Prevalence and Relationship with Disease Severity

Giavedoni

Podlipnik

Pericàs

et al. 2020

JCM

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“…They additionally performed a real‐time PCR assay for SARS‐CoV‐2 that was negative in four tested cases 1 . Regarding their case using histopathological pictures, we agree with their description as we can observe acantholytic cells, some of them with dyskeratotic features or grouped without a clear moulding of nucleus, but reminiscent of the multinucleated giant cells typically observed in herpetic lesions, a picture that looks to our eyes, most likely to be a rare entity named pseudoherpetic Grover disease (GD), 2 first described as vesicular GD by Fernandez‐Figueras et al 3 …”

Section: Figurementioning

confidence: 99%

“…2). In our series of pseudoherpetic GD, we did not find any viral inclusions, and immunostaining for herpesvirus and varicella were negative in all the cases 2 …”

Section: Figurementioning

confidence: 99%

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Comment on ‘Clinical and histological characterization of vesicular COVID‐19 rashes: a prospective study in a tertiary care hospital’. Pseudoherpetic Grover disease seems to occur in patients with COVID‐19 infection

et al. 2020

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“…The main subtypes of acantholysis observed in Grover's disease include Darier's disease type, Hailey-Hailey type, pemphigus type, and spongiotic type [2,3]. Follicular and pseudoherpetic types of acantholysis have also been reported [12]. Histopathological examination is necessary for diagnosing Grover's disease, though there are also literature reports describing the identification of the disorder by dermoscopy.…”

Section: Omówieniementioning

confidence: 99%

Grover’s disease

Jakubowicz-Zalewska¹,

Kuryłek²,

Ludwiniak³

et al. 2020

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Introduction: Grover's disease (transient acantholytic dermatosis) is a rare skin disease characterised by papules or vesicles located mainly on the chest and proximal limbs, and accompanied by pruritus. The disorder is most prevalent in elderly men. Histopathologically, it presents with foci of acantholysis and dyskeratosis. The course of the disease is usually mild, however systemic therapy might be required. Objective: To present the case of a patient with Grover's disease. Case report: A 78-year-old man after resection and radiotherapy for prostate cancer was admitted to the Dermatology Department for the diagnosis of multiple papular and vesicular eruptions located on the torso and limbs. The skin lesions were accompanied by pruritus which intensified after sweating and hot baths. Based on the results of histopathological and clinical examinations, the diagnosis of Grover's disease was made. Oral acitretin at 25 mg/day was initiated. The skin condition improved significantly, and pruritus resolved. Conclusions: On account of the rarity of the condition and polymorphic skin lesions, the diagnosis and treatment of Grover's disease can be a challenge. stresZCZenIe Wprowadzenie: Choroba Grovera (przejściowa dermatoza akantolityczna) jest rzadką dermatozą charakteryzującą się występowaniem grudek lub pęcherzyków, głównie na tułowiu i proksymalnych częściach kończyn, z towarzyszącym świądem. Najczęściej występuje u mężczyzn w starszym wieku. W badaniu histopatologicznym stwierdza się ogniska akantolizy i dyskeratozy. Z reguły przebieg choroby jest łagodny, ale może wymagać leczenia ogólnego. Cel pracy: Przedstawienie pacjenta, u którego rozpoznano chorobę Grovera. Opis przypadku: Mężczyzna 78-letni, po przebytej resekcji i radioterapii raka gruczołu krokowego, został przyjęty do Kliniki Dermatologii w celu diagnostyki zmian skórnych w postaci licznych wykwitów grudkowych i pęcherzykowych w obrębie skóry tułowia i kończyn. Zmianom towarzyszył świąd nasilający się po spoceniu i gorącej kąpieli. Na podstawie wyniku badania histopatologicznego oraz obrazu klinicznego rozpoznano chorobę Grovera. Do leczenia włączono acytretynę w dawce 25 mg/dobę. Uzyskano znaczną poprawę stanu skóry oraz ustąpienie świądu.

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Clinico-Pathological Study of 4 Cases of Pseudoherpetic Grover Disease: The Same as Vesicular Grover Disease

Cited by 9 publications

References 9 publications

Skin Manifestations in COVID-19: Prevalence and Relationship with Disease Severity

Skin Manifestations in COVID-19: Prevalence and Relationship with Disease Severity

Comment on ‘Clinical and histological characterization of vesicular COVID‐19 rashes: a prospective study in a tertiary care hospital’. Pseudoherpetic Grover disease seems to occur in patients with COVID‐19 infection

Grover’s disease

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