2014
DOI: 10.1016/j.ejca.2014.08.009
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Clinico-pathological significance of the molecular alterations of the SPOP gene in prostate cancer

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Cited by 43 publications
(46 citation statements)
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“…To the best of our knowledge very few papers have previously investigated the impact of the deregulation of SPOP at mRNA or protein level in prostate carcinogenesis . In this regard, García‐Flores et al reported that SPOP was strongly downregulated in PrCa at mRNA level, and that expression was inversely associated with biochemical and clinical progression‐free survival and with Gleason score. Low levels of SPOP independently predicted a worse prognosis.…”
Section: Discussionmentioning
confidence: 96%
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“…To the best of our knowledge very few papers have previously investigated the impact of the deregulation of SPOP at mRNA or protein level in prostate carcinogenesis . In this regard, García‐Flores et al reported that SPOP was strongly downregulated in PrCa at mRNA level, and that expression was inversely associated with biochemical and clinical progression‐free survival and with Gleason score. Low levels of SPOP independently predicted a worse prognosis.…”
Section: Discussionmentioning
confidence: 96%
“…The percentage of SPOP mutations reported in the Catalogue of Somatic Mutations is 8% and that of TCGA Project is 11%. Other studies have also reported frequencies of 6%‐13% in primary and 14.5% in metastatic cancers . A comprehensive analysis of the SPOP gene in samples from six international cohorts, revealed SPOP mutations in 4.6% to 14.4% of the patients with PrCa, across different ethnic and demographic backgrounds, but without any association with ethnicity, clinical, or pathologic parameters .…”
Section: Discussionmentioning
confidence: 97%
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“…A recent study found no association between SPOP mutation and clinical or pathological parameters 43 ; however, others have reported that mutations and decreased expression of the SPOP gene are associated with worse progression free survival 46 . Functionally, SPOP mutation has been shown to modulate carcinogenesis by preventing the degradation of oncogenic factors including ERG and the androgen receptor 4751 .…”
Section: Introductionmentioning
confidence: 93%
“…Thus, elevation of SRC-3 by a mutant SPOP may also contribute to the transcriptional activation of AR. In addition to mutations, SPOP can be downregulated in prostate cancer (27, 28), and this may provide another mechanism to increase AR stability and transcriptional activity. Additional studies will help clarify the role of SPOP in CRPC.…”
Section: Spop Regulates Transcriptional Output Of Ar By Controlling Gmentioning
confidence: 99%