Clinico-pathological review of malignent gastric tumours in Lagos, Nigeria.

Abdulkareem, F B; Onyekwere, Charles; Awolola, N A; Ajekigbe, AT

doi:10.4314/nqjhm.v20i2.58021

Cited by 5 publications

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“…11 In the study by Abdul Kareem et al there were 95 cases (90%) of adenocarcinomas, 8 (7.6%) mesenchymal tumours with one case each of small cell non-Hodgkin's lymphoma and carcinoid tumour. 4 In the present study according to Borrmann classification type I (21.73%) and type II tumour constituted (66.09%) of the lesions.…”

Section: Resultssupporting

confidence: 43%

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Clinicopathological study of carcinoma stomach over a period of 5 years

2017

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INTRODUCTIONGastric cancer is the most common cancer in the world accounting for 10% of all cancers. Over all rates in men are approximately double than the females.1 There is marked difference in the incidence between north and south India. Stomach cancer admission in south India was 4 times as frequent as in north India with a remarkable preponderance of males (20: 1) versus (7:1) in rest of India. In Kashmir the incidence is 3-6 times higher than rest of India.2 Endoscopy served as primary diagnostic procedure for diagnosing carcinoma stomach and has 80% accuracy the remaining 20% are evaluated by histopathological examination. METHODSA total of 115 gastrectomy specimens received in a 5 year period at a tertiary care center in the department of pathology was analyzed. The clinical details, demographic status, socio economic status, dietary habits, intake of alcohol, smoking including their blood groups were recorded. After fixing the specimen in 10% formal saline for 24 hours the gross appearance of the specimen was studied. The gross findings were recorded following Borrmann classification. The tissue blocks from the representative portions of the lesion along with the normal tissue were taken and routinely processed. The paraffin embedded blocks were cut into 2-4 microns thick ABSTRACT Background: Gastric cancer represents one of the most frequent neoplasias. Although its incidence decreased over the last few decades in industrialized countries, it still represents nowadays a major cause of death through cancer throughout the world. The purpose of this study was to identify clinicopathological parameters in gastric carcinoma. Methods: A total of 115 gastrectomy specimen received in 5 year period at a tertiary care center was analyzed. The clinical data was recorded. After fixing the specimen in 10% formal saline for 24 hours the gross appearance of the specimen was studied. The gross findings were recorded following Borrmann classification. The tissue blocks were routinely processed and stained with H&E stain. The results were tabulated. Results: The prevalence of gastric carcinoma was 4.46%, with male: female ratio of 3:1 and mean age of 50years.The prevalence of carcinoma stomach was more common in rural areas and poor socio economic status. Sixty percent of patients who consumed mixed diet suffered from carcinoma and 82.8% had history of intake of alcohol. Carcinoma stomach was more common in A blood group. The tumor was more common in pyloric antrum (73.04%). According to Borrmann classification type II tumour was the commonest (66.09%) of the lesions. Commonest histological pattern was adenocarcinoma; intestinal type (86.72%). Conclusions:The prevalence of carcinoma stomach in the present study was 4.46%. High prevalence of gastric carcinoma was seen in patients with history of smoking, intake of alcohol and consumption of mixed diet. Carcinoma stomach was more common in A blood group followed by B blood group. Adenocarcinoma of intestinal type was the commonest.

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Section: Resultssupporting

confidence: 43%

“…Abdul Kareem et al analysed 105 cases of gastric cancer (M:F = 2:1, mean age-55.3 years), 81% of which occurred above 45 yrs. 4 Ahmed A et al in their study of 179 patients with gastric cancer, male to female ratio of 1.4:1 and mean age was 51±6.3. 5.6% patients presented with early gastric cancer.…”

Section: Resultsmentioning

confidence: 95%

Clinicopathological study of carcinoma stomach over a period of 5 years

2017

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“… 1 There is a wide geographical variation being highest in the Far East (Japan and China) and lowest in Africa. 2 3 4 5 6 The age-standardised incidence range from 3.3 in West African men to 35.4 in East Asian men; and from 2.6 in West African women to 13.8 in East Asian women. 1 …”

Section: Introductionmentioning

confidence: 99%

“…3 In Nigeria the prevalence rate is reported to be between 1.64% and 4.1% being highest in the South-West region and lowest in the North-East. 2 3 7…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological features of gastric carcinoma in Ibadan, Nigeria, 2000-2011

et al. 2015

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Aim:The most recent study on the clinicopathological features of gastric carcinoma from the University College Hospital (UCH), Ibadan, was done in 2000. The aim of this study is to update the knowledge on the clinicopathological features of gastric carcinoma diagnosed in the Pathology Department of the UCH Ibadan between 2000 and 2011.Materials and Methods:This was a 12-year retrospective review of clinical and demographic data and the histopathological features of gastric cancers diagnosed at the Pathology Department of the UCH. The chi square test, Fisher's exact test, and the t-independent test were used as applicable in the statistical analyses.Results:A total of 117 cases of gastric carcinoma were histologically diagnosed at the Pathology Department of UCH, Ibadan in this period giving a relative ratio frequency of 1.38% for all cancers. It represented 18.4% of all gastrointestinal tract malignancies diagnosed in the same period. There was a male preponderance with male:female ratio of 1.72:1; the middle-aged and elderly made up about 76.1% of cases. The disease was clinically and histologically advanced in 92.8% of cases. Gastric tumours were predominantly antral/ pyloric in 80% of cases and exophytic in 62.3% of cases. The intestinal histotype constituted 47.0% cases although a rise in the diffuse histological type was observed.Conclusion:There is a decline in the relative ratio frequency of gastric carcinoma in Ibadan; and a fall in the rate of the intestinal type of gastric carcinoma relative to the diffuse type when compared to previous studies from our centre.

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“…There was no retroperitoneal involvement and no perigastric nodes. 7,8 Preoperative workup was done. Patient was taken up for D2 subtotal gastrectomy.…”

Section: Figure 1 Upper Gastrointestinal Scopy Showing Proliferativementioning

confidence: 99%

Signet Ring Cell Gastric Carcinoma- A Case Report

Daniel¹,

Reddy²,

Prakash³

et al. 2018

jemds

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This 39-year-old female patient came to surgical outpatient department with the complaints of non-radiating upper abdominal pain and non-bilious vomiting for 1 week duration. There was history of loss of appetite, loss of weight and melena for past 1 month. 1-3 On examination, the patient was found to be poorly nourished, dehydrated and pale. There was no icterus/ no pedal oedema and no significant supraclavicular lymphadenopathy. Blood investigations showed Hb as 10.3 g/dL, PCV-34%, WBC-6,400 cells/cmm, Platelets-2,13,000 cells/cmm and ESR-02 mm. The blood grouping was A positive. Serum electrolytes assessment showed sodium levels of 135 mEq/L, Potassium-3.9 millimoles/lit, Chloride-103 mEq/L and Bicarbonate levels of 26 mEq/L. Renal function tests revealed Urea level as 27 mg/dL and Serum creatinine level as 0.9 mg/dL. 4,5,6 Upper gastrointestinal scopy done in this patient showed an Ulcerative growth involving the whole circumference of the antrum from the incisura to 1 cm start-up pylorus and lumen appeared narrowed (Figure 1).

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Clinico-pathological review of malignent gastric tumours in Lagos, Nigeria.

Cited by 5 publications

References 0 publications

Clinicopathological study of carcinoma stomach over a period of 5 years

Clinicopathological study of carcinoma stomach over a period of 5 years

Clinicopathological features of gastric carcinoma in Ibadan, Nigeria, 2000-2011

Signet Ring Cell Gastric Carcinoma- A Case Report

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