Clinico-pathological findings in stage-I primary spontaneous pneumothorax: analysis of 19 cases and literature review

Maria, Giuseppe Di; Criscione, Alessandra; Rassl, DM

doi:10.1007/s10353-012-0169-5

Cited by 4 publications

(5 citation statements)

References 16 publications

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“…However, there are also patients without blebs and bullae. Several studies show that these patients have parenchymal lung lesions [3,4]. These abnormalities include emphysema, pleural fibrosis and mesothelial thickening.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Initial management of primary spontaneous pneumothorax with video-assisted thoracoscopic surgery: a 10-year experience

Herrmann¹,

Klapdor

Ewig

et al. 2015

Eur J Cardiothorac Surg

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Section: Discussionmentioning

confidence: 99%

“…Surgical approaches include open thoracotomy, transaxillary mini-thoracotomy or video-assisted thoracoscopic surgery (VATS). These methods can be supplemented with different pleurodeses such as pleurectomy or pleural abrasion [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Initial management of primary spontaneous pneumothorax with video-assisted thoracoscopic surgery: a 10-year experience

Herrmann¹,

Klapdor

Ewig

et al. 2015

Eur J Cardiothorac Surg

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“…Other studies showed that these lesions were the result of a degenerative process of the Table 3 The distribution of allele genes in the promoter of MMP-9 (-1562 C/T) between the two groups. lung, and were considered as a form of distal acinar emphysema [21,22]. The primary mechanism of lung parenchymal destruction in emphysema is believed to be an imbalance between endogenous proteinases and antiproteinases.…”

Section: Discussionmentioning

confidence: 99%

Matrix Metalloproteinase-9 Promoter Polymorphism in Primary Spontaneous Pneumothorax

Baalash¹,

Ibrahim²

2015

JHS

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Primary spontaneous pneumothorax (PSP) is a common clinical problem occurring in apparently healthy subjects. However emphysema like changes (ELC) in patients with (PSP) has been demonstrated, which is associated with the degradation of extracellular matrix (ECM). MMP-9 has been proposed to play a role in the development of emphysema and is involved in the digestion of (ECM). Among several polymorphic changes reported in MMP-9 regulatory region, the C-1562T polymorphism increases its promoter activity. Aim of the work: To test the hypothesis that the MMP-9 C-1562T polymorphism has a role in the occurrence of PSP. Subjects and Methods: MMP-9 (C-1562T) genotypes of 104 PSP patients and 97 healthy subjects (control) were determined by the polymerase chain reaction, followed by a restriction fragment length polymorphism analysis. Results: This study showed that the genotype frequency for MMP-9 1562 C > T differed significantly between healthy individuals and PSP patients, with higher T allele in MMP-9 promoter in PSP patients, and the C/T + T/T genotypes significantly modified the risk of developing PSP, and were associated with increased risk for PSP. Conclusion: MMP-9-1562C/T genotype may be a potentially indicative factor for susceptibility to PSP, that is, genotypes with the T allele significantly increase the risk of development of PSP.

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“…The second case presented a patient with stage 1 pneumothorax, without any bulla/bleb: representing nearly 20% cases in experienced centres, with no current guidelines regarding further management (apical wedge resection, pleurodesis). M. Migliore shared his preference on performing a wedge resection, which may not have any implication in terms of recurrence prevention, but could aid in obtaining a definitive diagnosis of the cause of pneumothorax [ 6 ].…”

Section: Management Of Adult Spontaneous Pneumothoraxmentioning

confidence: 99%

“…Dr. Migliore shared his preference on performing a wedge resection, may not have any implication in terms of recurrence prevention, but could aid to obtain a definitive diagnosis of the cause of pneumothorax). 6 The current limitations on surgical management of pneumothorax are: no consensus on the size cut off for small versus large pneumothorax, insufficient evidence for management of persistent air leak, surgical approach (uniportal/multiportal), method of pleurodesis and strategies for Stage 1 pneumothorax. Dr. Migliore highlighted the unmet need of generating good quality evidence.…”

Section: Role Of Lung Parenchyma Resection In Recurrence Preventionmentioning

confidence: 99%

ERS International Congress 2023: highlights from the Thoracic Surgery and Lung Transplantation Assembly

Zajacova,

Scaramozzino,

Bellini

et al. 2023

ERJ Open Res

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Five sessions presented at recent European Respiratory Society Congress 2023 were selected by Assembly 8, consisting of thoracic surgeons and lung transplant professionals. Highlights covering management of adult spontaneous pneumothorax, malignant pleural effusion, infectious and immune-mediated complications after lung transplantation, as well as pro & con debate on age limit in lung transplantation and results of ScanCLAD study were summarized by early career members, supervised by the assembly faculty.

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Clinico-pathological findings in stage-I primary spontaneous pneumothorax: analysis of 19 cases and literature review

Cited by 4 publications

References 16 publications

Initial management of primary spontaneous pneumothorax with video-assisted thoracoscopic surgery: a 10-year experience

Initial management of primary spontaneous pneumothorax with video-assisted thoracoscopic surgery: a 10-year experience

Matrix Metalloproteinase-9 Promoter Polymorphism in Primary Spontaneous Pneumothorax

ERS International Congress 2023: highlights from the Thoracic Surgery and Lung Transplantation Assembly

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