Clinico-pathological features of tuberculosis due to mycobacterium tuberculosis Uganda genotype in patients with tuberculous lymphadenitis: a cross sectional study

Wamala, Dan; Asiimwe, Benon B.; Mbowa, Gerald; Kigozi, Edgar; Joloba, Moses; Källenius, Gunilla

doi:10.1097/01.pat.0000454440.86553.44

Cited by 2 publications

(4 citation statements)

References 20 publications

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“…The patients’ clinical, radiological and pathological features were described previously [ 12 ]. Of the patients in the study, 58 (47.9 %) were males with a mean age of 30.3 years and 62 (52.1 %) were females with a mean age of 27.1 years.…”

Section: Methodsmentioning

confidence: 99%

“…tuberculosis is the prevalent cause of PTB, and accounts for up to 70 % of isolates [ 11 ]. In a recent study of tuberculous lymphadenitis patients, we found that the Uganda genotype was also a major aetiological agent in EPTB [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…Our objective was to analyze the genetic diversity of the clinical isolates from this study [ 12 ], and to compare them with the genotypic patterns of PTB isolates reported previously in this setting [ 11 ] in order to understand the epidemiological and phenotypic characteristics of M . tuberculosis strains causing EPTB.…”

Section: Introductionmentioning

confidence: 99%

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Predominance of Uganda genotype of Mycobacterium tuberculosis isolated from Ugandan patients with tuberculous lymphadenitis

et al. 2015

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BackgroundIn Uganda, the emerging Uganda genotype of Mycobacterium tuberculosis is the most common cause of pulmonary tuberculosis (PTB), and accounts for up to 70 % of isolates. Extrapulmonary TB (EPTB) is less studied in Uganda.MethodsMolecular characterization using deletion analysis and spoligotyping was performed on 121 M. tuberculosis isolates from lymph node fine needle biopsy aspirates of Ugandan patients with tuberculous lymphadenitis. The evolutionary relationships and worldwide distribution of the spoligotypes were analyzed.ResultsMycobacterium tuberculosis was the only cause of EPTB in this study. The T2 sublineage was the most predominant lineage and the Uganda genotype was the dominant genotype. There were 54 spoligotype patterns among the 121 study isolates. The dominant spoligotypes were shared international types (SIT) SIT420, SIT53, SIT 135, SIT 128 and SIT590 in descending order. All but SIT420 were previously reported in pulmonary TB in this setting. The phylogenetic analysis showed a long descendant branch of spoligotypes belonging to the T2-Uganda sublineage containing specifically SITs 135, 128 and 420.ConclusionIn most cases, the spoligotypes were similar to those causing PTB, but the Uganda genotype was found to be less common in EPTB than previously reported for PTB in Uganda. The phylogenetic analysis and the study of the worldwide distribution of clustered spoligotypes indicate an ongoing evolution of the Uganda genotype, with the country of Uganda at the center of this evolution.Electronic supplementary materialThe online version of this article (doi:10.1186/s13104-015-1362-y) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Predominance of Uganda genotype of Mycobacterium tuberculosis isolated from Ugandan patients with tuberculous lymphadenitis

et al. 2015

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“…The Ugandal line, which is very common in Uganda (70%), is defined by the deletion of RD724 in combination with the lack of 33-36 spacers and spacer 40 and/or 43 by spoligotyping [38,39].…”

Section: Am J Biomed Sci and Resmentioning

confidence: 99%

Drug-Resistant Tuberculosis and Lines of Mycobacterium Tuberculosis Circulating in Kinshasa

Bajani¹,

Tamfum²,

Tumba

et al. 2019

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Clinico-pathological features of tuberculosis due to mycobacterium tuberculosis Uganda genotype in patients with tuberculous lymphadenitis: a cross sectional study

Cited by 2 publications

References 20 publications

Predominance of Uganda genotype of Mycobacterium tuberculosis isolated from Ugandan patients with tuberculous lymphadenitis

Predominance of Uganda genotype of Mycobacterium tuberculosis isolated from Ugandan patients with tuberculous lymphadenitis

Drug-Resistant Tuberculosis and Lines of Mycobacterium Tuberculosis Circulating in Kinshasa

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