Clinico-pathological Features of Gynecological Malignancies in a Tertiary Care Hospital in Eastern India: Importance of Strengthening Primary Health Care in Prevention and Early Detection

Sarkar, Moumita; Konar, Hiralal; Raut, Deepak

doi:10.7314/apjcp.2013.14.6.3541

Cited by 13 publications

(10 citation statements)

References 17 publications

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“…Also, socioeconomic status, access to care, and lack of health insurance coverage correlates with delay in diagnosis, advanced stage, and impaired survival. Almost 80% of the cervical cancer in India present to a tertiary care hospital at a fairly advanced stage, thereby, reducing the treatment options and survival rate [30] , [31] , [32] . Hence, research is needed to identify the optimal way of implementation of cervical cancer diagnosis and prevention in India, taking into account the cost and the human resources [33] .…”

Section: Discussionmentioning

confidence: 99%

Clinical Impact of De-Regulated Notch-1 and Notch-3 in the Development and Progression of HPV-Associated Different Histological Subtypes of Precancerous and Cancerous Lesions of Human Uterine Cervix

et al. 2014

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BackgroundCervical cancer is the leading cause of cancer related deaths among women in India. Limited reports are available for Notch-1 and Notch-3 protein in cervical carcinoma, which play crucial role in cell proliferation, differentiation, and apoptosis.MethodsThis study was designed to evaluate the role of Notch-1 and Notch-3 with context to HPV infection in cervical carcinoma. A total of 168 tissue biopsy samples comprising of tumor specimens (n = 98), precancer (n = 30) and non-neoplastic cervical tissues (n = 40) were screened for HPV infection by PCR and expression of Notch-1 and Notch-3 protein by Immunohistochemistry and Immunoblotting.Results80% (24/30) were found to be positive for HPV in precancer and 86.7% (85/98) in cancer patients. Notch-1 expression of precancer and cancer cases was found to be significantly down-regulated with severity of disease in nuclear (3.43±0.29; 2.04±0.19, p = 0.0001, p = 0.0001) and cytoplasm (3.07±0.29; 2.29±0.17, p = 0.0001, p = 0.0001) obtained from different stages as compared to normal cervix tissue (5.40±0.19, 4.97±0.15; p<0.001; p<0.001). However, Notch-3 expression of above cases was significantly up-regulated with severity of disease and showed intense nuclear (4.17±0.39; 4.74±0.18, p = 0.0001, p = 0.0001) and cytoplasm (3.67±0.36; 4.48±0.18, p = 0.0001, p = 0.0001) of different stages as compared to normal cervix tissue (0.95±0.20, 0.70±0.20; p<0.001; p<0.001) respectively.ConclusionsThese findings suggest that Notch-1 and Notch-3 may play an important role with synergistic effect of HPV in regulating development and proliferation of cervical cancer through the deregulation of Notch signalling. This study also shows the clinical utility of both proteins which may be used as predictable biomarkers in diagnosing different histological sub-types of HPV associated cervical cancer. Nevertheless, abnormal activation of this pathway may provide legitimate targets for cervical cancer therapy.

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Section: Discussionmentioning

confidence: 99%

Clinical Impact of De-Regulated Notch-1 and Notch-3 in the Development and Progression of HPV-Associated Different Histological Subtypes of Precancerous and Cancerous Lesions of Human Uterine Cervix

et al. 2014

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“…Again about 70-90% was SCCs across all the registries in both sexes. Clinico-pathological features of Gynecological Malignancies (Sarkar et al, 2013) reported from a tertiary Care Hospital in eastern India disclosed that majority of the patients (61.0%) had SCC, followed by adenocarcinoma (30.1%). About 95% patients with cervical malignancy had SCC, whereas ovarian tumors more commonly had a diagnosis of adenocarcinoma (88.9%).…”

Section: Discussionmentioning

confidence: 99%

Audit of Cancer Patients from Eastern Uttar Pradesh (UP), India: A University Hospital Based Two Year Retrospective Analysis

Nandi

Mandal²,

Asthana³

2013

Asian Pacific Journal of Cancer Prevention

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“…Clinicopathological features of gynecological malignancies reported from a tertiary care hospital in eastern India disclosed that majority of the patients (61.0%) had SCC, followed by adenocarcinoma (30.1%). 23 Most of the cases (628%) at first presentation were fresh cases and 315 (36.51%) patients had received some form of therapy elsewhere before they came for treatment at our centre. On comparison with the data from HBCRs (2004)(2005)(2006) it was found across all registries in both the sexes that about 10-30% of cases had received prior treatment before their first presentation at the reporting institution.…”

Section: Discussionmentioning

confidence: 96%

An audit and analysis of cancer patients attending radiation oncology department: a tertiary care center experience

Das

Patra

2020

Int J Community Med Public Health

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Background: Cancer is a major public health problem worldwide and is the second leading cause of death in the developing countries. Among various diseases, cancer has become a big threat to human beings globally. As per Indian population census data, the rate of mortality due to cancer in India was high and alarming with about 8,06,000 existing cases by the end of the last century. In view of these facts, the present article describes the status of various types of cancers in the southern part of Odisha.Methods: A total of 1123 patients were registered in the department of radiotherapy, maharaja krushna chandra gajapati medical college, Odisha, during the period from January to December 2019 and were included for the retrospective analysis.Results: Females outnumbered males with a ratio of 1.32. Highest number of the patients belong to the age group of 60-69 years. Major cancer sites in females were cervix, breast followed by head and neck. Leading cancer sites in males were head and neck, stomach, rectum and lungs. Most of the cases presented in advanced stage of disease (78%). Squamous cell carcinoma was the most common histopathology (81%). A significant proportion of patients defaulted after undergoing preliminary investigations (27.4%). Out of the total (1123) population 482 patients received radiation and 760 patients received chemotherapy and 425 received supportive care.Conclusions: The outcome of this study will significantly help us to understand the cancer burden in southern Odisha and its distribution to define region specific strategies for cancer management.

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Clinico-pathological Features of Gynecological Malignancies in a Tertiary Care Hospital in Eastern India: Importance of Strengthening Primary Health Care in Prevention and Early Detection

Cited by 13 publications

References 17 publications

Clinical Impact of De-Regulated Notch-1 and Notch-3 in the Development and Progression of HPV-Associated Different Histological Subtypes of Precancerous and Cancerous Lesions of Human Uterine Cervix

Clinical Impact of De-Regulated Notch-1 and Notch-3 in the Development and Progression of HPV-Associated Different Histological Subtypes of Precancerous and Cancerous Lesions of Human Uterine Cervix

Audit of Cancer Patients from Eastern Uttar Pradesh (UP), India: A University Hospital Based Two Year Retrospective Analysis

An audit and analysis of cancer patients attending radiation oncology department: a tertiary care center experience

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