Clinico pathological correlation of leprosy: A 4 years retrospective study from a tertiary referral centre in north India

Shirazi, Nadia; Jindal, Rashmi; Ahmad, Shazaad; Sds, Rawat; N, Selvi Thamarai; Harsh, Meena

doi:10.5958/2319-5886.2015.00065.x

Cited by 7 publications

(10 citation statements)

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“…In the present study the histopathological characteristics were consistent with the clinical diagnosis in 44 cases out of 70 cases (62.85%), similar to the observation made by Nadia et al 6 . .…”

Section: Discussionsupporting

confidence: 79%

Clinical and Histopathological Correlation in Hansen’s Disease

Arunagirinathan

Muniswamy²,

Jeevirathinam³

2017

APALM

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Background: The present study was carried out to correlate clinical diagnosis of new leprosy cases with that of histopathological diagnosis of skin biopsies stained with Haematoxylin and Eosin followed by Fite Faraco stain.Method: Skin biopsies of 70 newly diagnosed leprosy patients were fixed in 10% formalin and routine histopathological examination done followed by special stain (Fite Faraco) to evaluate the bacterial index.Results: From this study it was observed that, the commonest age group affected by leprosy was 31 to 50 years, males are twice more commonly affected than females (M:F = 1.9 : 1) and the most commonest clinically diagnosed spectrum was Tuberculoid leprosy (TT). The commonest histopathologically diagnosed spectrum was Indeterminate leprosy(IL). It was observed that there was complete agreement between clinical diagnosis and histopathological diagnosis in 62.85% cases and disagreement was observed in 37.15% cases. Conclusion:In case of confirmed discrepancy, the more advanced findings (ie. towards the lepromatous pole) should be given greater weightage and the case is to be classified and treated accordingly.

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Section: Discussionsupporting

confidence: 79%

Clinical and Histopathological Correlation in Hansen’s Disease

Arunagirinathan

Muniswamy²,

Jeevirathinam³

2017

APALM

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“…The least clinicopathologic correlation was noted in midborderline leprosy and similar results were obtained was also noted by Manandhar et al, [7] Sharma et al, [1] Moorthy et al [16] . This is due to the highly unstable immune status.…”

Section: Discussionsupporting

confidence: 74%

“…Leprosy is an infectious disease with history travelling as early as 600 BC [1] for cases of leprosy and has was considered as a curse to humankind. Leprosy is also known as Hansens disease named after Dr. Gerhard Henrik Armauer Hansen the person known for the numerous researches in Leprosy and proving it to be an infectious disease caused by a bacteria rather than a curse or sin to mankind.…”

Section: Introductionmentioning

confidence: 99%

“…[3] This disease presents with a long incubation period ranging from few weeks to 30 years with an average of 3 to 5 years. [1] Depending on the immunity, clinical and histopathological features various types of leprosy may develop. [4] Ridley and Jopling in 1966 proposed a histologic classification for leprosy based on the immunological spectrum into five groups that includes indeterminate leprosy (IL), Tuberculoid leprosy (TL), Borderline Tuberculoid leprosy (BT), Mid-Borderline leprosy (BB), Borderline lepromatous leprosy (BL) and Lepromatous leprosy (LL).…”

Section: Introductionmentioning

confidence: 99%

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India’s Hidden Disease: Retrospective Study Of Hansen Disease In A Tertiary Care Hospital

Ebenezer

Chander

Chitra

2018

APALM

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Background: Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae. There are various clinico-pathological forms of leprosy depending on the immune status of the host. Diagnosis of leprosy can be done by clinical, microbiological and histopathological examination. Histopathological examination is considered as important for confirmatory diagnosis, for assessment of the disease in patient's under treatment and also for research purposes Methods: A total of 28 skin biopsies of leprosy patients were studied in the Department of Pathology in Saveetha medical college over 7 year's duration (2008 -2015). A Ridley Jopling classification was used for the diagnosis and classification of the disease. All biopsies were stained with haematoxylin and eosin and Fite faraco. Clinico-histopathological correlation was done Result:In this study, number of males (23cases) (82%) were more than the number of females (5 cases) (18%) Mean age of patients was 40 years. The Most common presentation of the lesion was hypopigmented macule involving two areas (13cases). Among 28 cases maximum cases were classified as borderline tuberculoid leprosy (8cases) (28.6%) and least number of cases classified as histiod leprosy (1 case) (3.6%). Fite faraco stain was positive for 3 cases in tuberculoid spectrum and 9 cases in lepromatous spectrum. Conclusion:The current primary goal is early diagnosis of this disease in order to interrupt the transmission by early treatment. Histopathological examination is gold standard in confirmation of its diagnosis and its classification. As new immerging technique become available for the early diagnosis of leprosy, skin biopsies will continue to compliment these for providing more insights into the pathology of this disease.

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“…9 Fite-Faraco stain is applied for diagnostic purpose to demonstrate the acid-fast lepra bacilli, which are usually scanty. 10 Lupus vulgaris is a chronic progressive form of cutaneous tuberculosis. The lesions are small red-brown-colored gelatinous papules (apple-jelly nodules) that gradually evolve into large Flowchart 2: Algorithmic approach to diagnosis of epithelioid granulomas with and without necrosis Flowchart 3: Algorithmic approach to diagnosis of epithelioid granulomas with fibrinoid necrosis and epithelioid granulomas with endogenous material plaques as a result of central atrophy and extension to the periphery.…”

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confidence: 99%

Histopathological Spectrum of Granulomatous Skin Lesions: A Review

George¹

2019

SBV Journal of Basic, Clinical and Applied Health Science

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Background and objectives: Granulomatous dermatoses are the most frequently encountered dermatological disorders in tropical countries with leprosy and tuberculosis as the leading causes. Although granulomatous skin lesions are very prevalent in society today, dermatopathologists often face diagnostic challenges while reporting these lesions due to the similar histopathological features or tissue reaction patterns seen in these lesions with diverse etiologies. The purpose of this study is to review the various causes and patterns of granulomatous skin lesions and a sequential approach to diagnosis of individual lesions accurately. Materials and methods: A comprehensive search of all literature available on granulomatous skin diseases between 2000 and 2018 was conducted, using keywords such as "granulomatous dermatosis, " "cutaneous tuberculosis, " "leprosy, " and "histopathological study" in the databases such as PubMed, ProQuest, and Google Scholar. The articles that satisfied the criteria were included in the final review. Results: The available evidence from the existing systematic literature reviews and articles suggested that the various tissue reaction patterns observed in granulomatous skin lesions are classified as epithelioid, palisaded, suppurative, xanthogranulomatous, foreign body, and other granulomatous patterns. These tissue reaction patterns are caused by infections, foreign bodies, metabolites, chemicals, and malignancies. Conclusion: Granulomatous dermatoses are a heterogeneous group of skin disorders that are frequently encountered in diagnostic dermatopathology. The histomorphology of a granuloma has to be correlated with the clinical history and ancillary techniques including special stains, culture, and molecular methods are necessary to arrive at a definitive diagnosis.

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Clinico pathological correlation of leprosy: A 4 years retrospective study from a tertiary referral centre in north India

Cited by 7 publications

References 0 publications

Clinical and Histopathological Correlation in Hansen’s Disease

Clinical and Histopathological Correlation in Hansen’s Disease

India’s Hidden Disease: Retrospective Study Of Hansen Disease In A Tertiary Care Hospital

Histopathological Spectrum of Granulomatous Skin Lesions: A Review

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