Clinico-pathological characteristics of colorectal carcinoma at university teaching hospital, Nepal

Shah, Surendra; Shrestha, Samir; Shah, Jay; Paudyal, Sanjaya

doi:10.3126/jpahs.v1i2.16644

Cited by 6 publications

(9 citation statements)

References 8 publications

(11 reference statements)

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“…Colorectal carcinoma was found to be more common among the age group of 51-60 years which was similar to the findings of a study done by Shah S et al 14 It is a matter of great concern that out of all colorectal cancers, 22.6% cases were found below 40 years which was 28.77% in a study of Shah et al 14 Malignancy was found to be more prevalent among male with M: F ratio of 1.6:1. The finding of Kansakar et al 15 was found to be 4:3 however, it was found to be equal in as study done by Shah S et al 14 and Khan MR et al 16 Stomach was found to be the second most commonly involved site comprising 28.6% however it was only 19.2% and 15.9% in a study done by Mohammad AM et al 17 and Jose L et al 18 respectively. Gastric carcinoma was found to be slightly more prevalent among male with M: F ratio of 1.4:1 but it was found to be 3:1 in a study done by Mohammad AM et al 17 Regarding age involvement, the finding of Mohammad AM et al 17 is similar to our finding as Gastric carcinoma was found to be less prevalent below 50 years (13.6%).…”

Section: Discussionsupporting

confidence: 90%

A study of gastrointestinal tumors at kathmandu medical college teaching hospital

Pradhan

Maharjan

et al. 2018

J Pathol Nep

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Background: Gastrointestinal tract tumour is responsible for more cancers and death than any other cancers. The tumour in GIT include the tumour of the Oral cavity, Esophagus, Stomach, Colon, Rectum, Liver, Gallbladder, Pancreas and Biliary tree.Materials and methods: A cross sectional study was carried out among all the gastrointestinal tract tumours specimens received for histopathological examination in between January 2016 to June 2017 in Department of Pathology, Kathmandu Medical College Teaching Hospital. All tumors diagnosed either benign or malignant were included in this study. Ethical clearance was obtained from the Institutional Review Committee in KMCTH.Results: Colorectum was found to be the most commonly involved site for malignant lesion comprising 40.2% among all malignant lesions followed by stomach comprising 28.6%. Malignancy was found to be more prevalent among male with M:F ratio of 1.6:1 in colorectal region and 1.4:1 in stomach cancers. Regarding benign lesions (polyps), rectum was found to be the commonest site (57.5%), followed by colon (20.0%) and stomach, the least common site.Malignant lesions were more common among the age group of 51-60 years (37.66%) with 70.13% above 50 years. Benign lesions were also found to be the most common above 50 years comprising 40.0 percent.Conclusion: Rectum & colon was found to be the most commonly involved site for both malignant and benign lesion. Malignancy is more prevalent among male and common above 50 years of age. However, malignant cases noted in the adult age group are a matter of great concern.

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Section: Discussionsupporting

confidence: 90%

A study of gastrointestinal tumors at kathmandu medical college teaching hospital

Pradhan

Maharjan

et al. 2018

J Pathol Nep

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“…of 51.76 ± 15.78 years. These findings were similar to findings of Vaidya et al 3 , Rajbhandari et al 2 and Shah et al 14 where age ranged from 16 to 87 years and mean age was 51.80, 52 and 53 years respectively. Males were more commonly affected than females with a male female ratio of 1.7:1.…”

Section: Original Research Article Polyps and Cancer Of Colorectumsupporting

confidence: 91%

“…Males were more commonly affected also in studies conducted by Vaidya et al 3 , Shrestha et al 15 and Ibrahim et al 16 with male female ratio of 3:1, 1.4:1 and 1.5:1 respectively. However, females were slightly more commonly affected in studies conducted by Shah et al 14 and Rajbhandari et al 2 with male female ratio of 0.9:1 and 1:1.08 respectively. 64.2% cases were seen in distal colon and 35.8% cases were seen in proximal colon which was similar to studies of Rajbhandari et al 2 and Vaidya et al 3 51.3% cases of malignancy were seen in rectum.…”

Section: Original Research Article Polyps and Cancer Of Colorectummentioning

confidence: 83%

“…17 Adenocarcinoma was the most common malignancy seen in 93.8% cases and majority (45.3%) were well differentiated. Several studies conducted by Vaidya et al 3 , Shah et al 14 , Kansakar et al 18 and Rawal et al 19 have also shown that adenocarcinoma was the most common malignancy, however, in their studies, moderately and poorly differentiated tumors were more common. In study conducted by Ibrahim et al 16 , well differentiated carcinoma was most common comprising 52.3% cases which is in accordance with present study.…”

Section: Original Research Article Polyps and Cancer Of Colorectummentioning

confidence: 89%

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Histopathology of Polyps and Cancer of Colorectum: A ten years study from a tertiary care center

Goyal

2021

JGMC Nepal

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Introduction and objectives: Polyps and colorectal cancer have overlapping clinical presentation and may be difficult to diagnose on clinical grounds alone and close clinicopathological correlation is required for correct diagnosis and management. This study was aimed to see the spectrum of polyps and cancer in colorectum, see the percentage of colorectal cancer in younger individuals, see association between histologic grade and pathologic stage at presentation and compare site of tumor and pathologic stage at presentation in younger and older age group. Methods: This study was carried out on 138 consecutive cases of polyps and malignant lesions of colorectum during a time period of 10 years from January 2011 to December 2020. Results: Age of the patients ranged from 2 – 90 years with mean 45.1 years and a male female ratio 2:1. There were 58 (42.0%) cases of polyps and 80 (58.0%) cases of malignancies. 37 (46.3%) malignancy cases were seen in individuals ≤ 50 years of age. Most common site of involvement was rectum in 80 (58.0%) cases. Most common non-neoplastic polyp was retention polyp comprising 25 (67.6%) and most common neoplastic polyp was adenoma comprising of 18 (85.7%) cases. Most common malignancy was adenocarcinoma comprising 75 (93.8%) cases. Conclusion: Significant number of malignancies is seen in younger individuals stressing the need for suspicion and surveillance in this age group. Histologic grade is an important prognostic parameter and there is no difference in site of tumor and stage at presentation between younger and older age group.

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“…[3][4][5][6][7] Few studies in Nepal have also showed the increasing overall trends in CRC in young population. [8][9][10][11] The main objective of our study was to estimate the burden of CRC among young. The secondary objective was to highlight the need of awareness among medical personnel and general population regarding need of earlier screening strategies to prevent over all deaths from CRC in our country.…”

Section: Introductionmentioning

confidence: 99%

Colorectal Cancer in Young Age Group: Where Do We Stand?

et al. 2019

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Colorectal cancers in young are in increasing trend. Young patients tend to ignore symptoms and present at advanced stage due to aggressive tumour biology, and also due to traditional dictum of routine screening after >50 years these groups of patients are given less priority. The objective of our study was to estimate the burden of problem among young population and increase awareness among medical personnel and general population of early detection for disease. We conducted retrospective cross sectional study using whole sampling method among patients operated by single gastrointestinal surgery unit. Demographic details, malignancy information, surgical procedure and histopathological examination were studied. All cases admitted as colorectal cancer from 2013 to 2017 at gastrointestinal surgery unit of Shree Birendra Hospital were included. The collected data were entered in SPSS version 16 and analyzed. Likelihood of occurrence of adenocarcinoma was studied using logistic regression model. Among total 104 cases operated, only 99 cases were having complete data with median age: 55 years. Thirty seven percent of the individuals having colorectal malignancies were younger than 50 years. Rectum was the commonest site (52, 52.5%) for occurrence of colorectal malignancy. Males were 1.493 (0.402-5.545) times more likely to have colorectal adenocarcinoma than females. Young age (<50 years) was associated with an increased likelihood of colorectal adenocarcinoma {OR=1.771(0.443-7.233)} than older people. Colorectal cancer in young age is in increasing trends. Increasing awareness among medical personnel and general population is must for early detection.

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Clinico-pathological characteristics of colorectal carcinoma at university teaching hospital, Nepal

Cited by 6 publications

References 8 publications

A study of gastrointestinal tumors at kathmandu medical college teaching hospital

A study of gastrointestinal tumors at kathmandu medical college teaching hospital

Histopathology of Polyps and Cancer of Colorectum: A ten years study from a tertiary care center

Colorectal Cancer in Young Age Group: Where Do We Stand?

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