Clinico-microbiological profile of Burkholderia cepacia keratitis: a case series

Ho, Ming-Chih; Kang, Eugene Yu-Chuan; Yeh, Lung‐Kun; David, H. K.; Lin, Hsin-Chiung; Tan, Hsin-Yuan; Chen, Hung-Chi; Hsiao, Ching-Hsi

doi:10.1186/s12941-020-00407-6

Cited by 5 publications

(4 citation statements)

References 17 publications

(22 reference statements)

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“…Another study revealed that 'quorum sensing' (QS) enabled Burkholderia cepacia to produce virulent factors and biofilms, thus destroying the host's innate immunity, especially epithelial cells, neutrophils, and megaphagocytes in patients with cystic fibrosis (Ganesh et al, 2020). Similar results were observed in patients with keratitis (Ho et al, 2021). Wessels et al also reported that Burkholderia enriched the endometrium of symptomatic patients with pelvic pain but without endometriosis, as confirmed by surgery (Wessels et al, 2021).…”

Section: Discussionmentioning

confidence: 88%

Endometrial microbiota in women with and without adenomyosis: A pilot study

Lin

Duan²,

Wang³

et al. 2023

Front. Microbiol.

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IntroductionThe endometrial microbiota plays an essential role in the health of the female reproductive system. However, the interactions between the microbes in the endometrium and their effects on adenomyosis remain obscure.Materials and methodsWe profile endometrial samples from 38 women with (n=21) or without (n=17) adenomyosis to characterize the composition of the microbial community and its potential function in adenomyosis using 5R 16S rRNA gene sequencing.ResultsThe microbiota profiles of patients with adenomyosis were different from the control group without adenomyosis. Furthermore, analysis identified Lactobacillus zeae, Burkholderia cepacia, Weissella confusa, Prevotella copri, and Citrobacter freundii as potential biomarkers for adenomyosis. In addition, Citrobacter freundii, Prevotella copri, and Burkholderia cepacia had the most significant diagnostic value for adenomyosis. PICRUSt results identified 30 differentially regulated pathways between the two groups of patients. In particular, we found that protein export, glycolysis/gluconeogenesis, alanine, aspartate, and glutamate metabolism were upregulated in adenomyosis. Our results clarify the relationship between the endometrial microbiota and adenomyosis.DiscussionThe endometrial microbiota of adenomyosis exhibits a unique structure and Citrobacter freundii, Prevotella copri, and Burkholderia cepacia were identified as potential pathogenic microorganisms associated with adenomyosis. Our findings suggest that changes in the endometrial microbiota of patients with adenomyosis are of potential value for determining the occurrence, progression, early of diagnosis, and treatment oadenomyosis.

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Section: Discussionmentioning

confidence: 88%

Endometrial microbiota in women with and without adenomyosis: A pilot study

Lin

Duan²,

Wang³

et al. 2023

Front. Microbiol.

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“…Ultraviolet A light used to carry out corneal collagen cross-linking could cause or trigger reactivation of latent HSV in a patient without clinical symptoms[ 310 ]. HSK has been reported to predispose individuals to be affected by Burkholderia cepacia which usually affects people with cystic fibrosis or immunocompromised[ 311 ]. Montgomery et al [ 312 ] postulated that ocular glands could be affected by HSV infection or other bacterial infections of the cornea[ 312 ].…”

Section: Complications Of Herpes Simplex Keratitis: Corneal Scarring ...mentioning

confidence: 99%

Herpes simplex keratitis: A brief clinical overview

Musa,

Enaholo,

Aluyi-Osa

et al. 2024

World J Virol

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The aim of our minireview is to provide a brief overview of the diagnosis, clinical aspects, treatment options, management, and current literature available regarding herpes simplex keratitis (HSK). This type of corneal viral infection is caused by the herpes simplex virus (HSV), which can affect several tissues, including the cornea. One significant aspect of HSK is its potential to cause recurrent episodes of inflammation and damage to the cornea. After the initial infection, the HSV can establish a latent infection in the trigeminal ganglion, a nerve cluster near the eye. The virus may remain dormant for extended periods. Periodic reactivation of the virus can occur, leading to recurrent episodes of HSK. Factors triggering reactivation include stress, illness, immunosuppression, or trauma. Recurrent episodes can manifest in different clinical patterns, ranging from mild epithelial involvement to more severe stromal or endothelial disease. The severity and frequency of recurrences vary among individuals. Severe cases of HSK, especially those involving the stroma and leading to scarring, can result in vision impairment or even blindness in extreme cases. The cornea's clarity is crucial for good vision, and scarring can compromise this, potentially leading to visual impairment. The management of HSK involves not only treating acute episodes but also implementing long-term strategies to prevent recurrences and attempt repairs of corneal nerve endings via neurotization. Antiviral medications, such as oral Acyclovir or topical Ganciclovir, may be prescribed for prophylaxis. The immune response to the virus can contribute to corneal damage. Inflammation, caused by the body's attempt to control the infection, may inadvertently harm the corneal tissues. Clinicians should be informed about triggers and advised on measures to minimize the risk of reactivation. In summary, the recurrent nature of HSK underscores the importance of both acute and long-term management strategies to preserve corneal health and maintain optimal visual function.

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“…изучали микробиологические данные и эффективность противомикробных средств при дефектах роговицы с инфильтратами и гипопионом (рис. 5) [18].…”

Section: лечение конъюнктивитаunclassified

“…The central epithelial layer of the cornea lesion with a defect in the cornea, with infiltration, hypopyon (according to M.C. Ho et al)[18]…”

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confidence: 99%

Analysis of the Assortability of Ophthalmologists Using a Therapy as Part of Routine Medical Care for Patients with Inflammatory Eye Diseases

2021

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The problem of diagnosis and treatment of inflammatory eye diseases takes a leading place in Russia and in the world, but the most important thing is the correct choice of treatment methods. Purpose of the work: collection and analysis of data on doctors’ preferences under prescribing therapy in patients with inflammatory eye pathology in routine clinical practice. As a result, 5960 clinical cases from 47 Russian cities were analyzed. This article compiles data from October to November 2020. 151 medical researchers were taken part in the participation of the recruitment. Doctors made different diagnoses for referring patients, but significantly more often diagnosis H10.3 was detected — 17.99 % (in 1072 patients). Ophthalmologists preferred to prescribe the following combination of drugs: 1 — antibacterial local, 2 — local antiseptics, 3 — non-steroidal anti-inflammatory local, a combination (antibiotic and glucocorticosteroid), antiallergic in the form of drops of local action. The choice of drugs for inflammatory eye disease is determined by their high efficiency of use for a given disease: antibiotic Signicef® (levofloxacin 0,5 %), nonsteroidal anti-inflammatory drug Broxinac® (bromphenac 0,09 %), fixed combination Kombinil® (ciprofloxacin 0,3 % + dexamethasone 0,1 %), Visallergol® (olopatadine 0,2 %) in the form of topical eye drops.

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Clinico-microbiological profile of Burkholderia cepacia keratitis: a case series

Cited by 5 publications

References 17 publications

Endometrial microbiota in women with and without adenomyosis: A pilot study

Endometrial microbiota in women with and without adenomyosis: A pilot study

Herpes simplex keratitis: A brief clinical overview

Analysis of the Assortability of Ophthalmologists Using a Therapy as Part of Routine Medical Care for Patients with Inflammatory Eye Diseases

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