Clinico-hematological study of pancytopenia

Lakhey, A; Talwar, OP; Vk, Singh; Kc, Shiva Raj

doi:10.3126/jpn.v2i3.6023

Cited by 13 publications

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“…Cases of malaria had splenomegaly more co mmonly in the studies of Khunger et al (100%) and Gayatri et al (100%) compared to this study (65.2%), whereas hepatomegaly and ly mphadenopathy was not seen in either of the said studies [4,9].…”

Section: Original Research Articlecontrasting

confidence: 48%

“…In [4,6,9]. Majority of the cases presented with weakness/ fatigue (90%) followed by pallor (66%) and dyspnoea (50%), wh ile a s mall proportion of patients had bleeding manifestations (6%).…”

Section: Discussionmentioning

confidence: 99%

“…These usually cause mild reversible marro w suppression, but may occasionally progress to more severe damage [16]. [4,9].…”

Section: Original Research Articlementioning

confidence: 99%

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Pancytopenia: A multidisciplinary assessment of hemato-etiological and clinical spectrum in a tertiary care hospital

Katti

Shankar

Patil

et al. 2018

Trop J Pathol Microbiol

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Background:The causes of pancytopenia range from simp le, co mp letely treatable diseases to serious life-threatening conditions. A thorough evaluation of these cases is mandatory as it would benefit the patients to receive appropriate treatment. Objecti ves: Evaluation of etio-hematological and clin ical spectrum of pancytopenia. Settings and Design: A prospective study of two years (Jan 2016 -December 2017) was conducted on pancytopenic patients, attending Navodaya Medical Co llege, Hospital and Research Centre, Raichur, Karnataka. Material and Methods: Etio-hematological and clin ical evaluation was done considering the relevant biochemical and serological investigations. Results: A total number of 1368 of cases were diagnosed as pancytopenia. The patients' age ranged from 19 to 68 years and M: F ratio was 2.1:1. Most frequent clinical symptom was generalized weakness (90%) and least was bony pain (2%). Peripheral smear examination revealed predominantly macrocytic blood picture (47.9%). Bone marrow aspiration was performed in 444 cases (32.4%), among which Megaloblastic anaemia (Exclusive and Co mb ined with iron deficiency anemia) was the commonest (52.7%). Et iologies of pancytopenia in decreasing order of frequency included Megaloblastic anemia {935 cases (68.4%) -Exclusive type (713 cases; 52.2%) and Combined with iron deficiency anemia (222 cases;16.2%)z, followed by Dengue fever (141 cases;10.3%), Hypoplastic/Aplastic anemia [106 cases;7.8% (Drug induced -4 cases; 0.2%)], Septicemia (60 cases;4.5%), Leukemia (46 cases;3.25%), Ch ronic malaria (46 cases ;3.25%) and Myelodysplastic syndrome (34 cases; 2.5%). Conclusion: Keeping in mind varied et iologies of pancytopenia, thorough diagnostic evaluation is required to achieve better clinical outcome.

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Section: Original Research Articlecontrasting

confidence: 48%

Section: Discussionmentioning

confidence: 99%

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Pancytopenia: A multidisciplinary assessment of hemato-etiological and clinical spectrum in a tertiary care hospital

Katti

Shankar

Patil

et al. 2018

Trop J Pathol Microbiol

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“…11 Different studies showed different causes of Pancytopenia. According to the study done by Mir et al, 3 megaloblastic anaemia was 72.7% and acute leukaemia 6.8%, by Rehmani et al, 4 20% megaloblastic anemia and 27.05% aplastic anemia, by Gayathri et al, 6 Megaloblastic Anaemia 74% and Aplastic Anaemia 18%, by Vaiday S, 7 Megaloblastic anemia 34.95%, Aplastic anemia 31.33%, by Pereira ADS et al, 8 Megaloblastic anemia (60%), Aplastic anemia and leukemia (10% each), by R Pathak et al, 9 Hypoplastic anemia (42.15%) and Hematological malignancies (19.4%), by Lakhey et al, 10 Hypoplastic anemia (29.6%) and Hematological malignancies (27.78%), by Khodke K et al, 11 Megaloblastic anaemia (44) and Aplastic anaemia (14), by Graham S et al, 13 Normoblastic erythroid hyperplasia (30%), Megaloblastic anemia (20%), by Jha et al, 14 Hypoplastic anemia (29.05%) and Megaloblastic anemia (23.64%). Present study shows Hypoplastic anemia (27.5%) and Megaloblastic anemia (18.8%).…”

Section: Discussionmentioning

confidence: 99%

“…Lakhey et al, had 15 (27.78%) cases and Mir et al, had 9 (6.78%) cases in their studies and both found acute leukemia as the second most common cause of pancytopenia. 3,10 General population showed the occurrence of MDS as 5 per 1, 00,000 people. However, in older individuals of age more than 70 years, the incidence increases from 22-45 per 1, 00,000 people and increasing further with the age.…”

Section: Discussionmentioning

confidence: 99%

Clinicohematological Study of Pancytopenia in a Tertiary Care Hospital of Western Region of Nepal

et al. 2017

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Introduction: Pancytopenia is a relatively common hematological entity and is a manifestation of many illnesses which can be life threatening at times. The severity of pancytopenia and the underlying pathology determine the management and prognosis. This study was conducted to evaluate hematological and bone marrow findings in patients presenting with pancytopenia. Methods: It was a prospective study carried out in Department of Pathology, Manipal College of Medical Sciences, Pokhara, Nepal, during the period of January 2011 to December 2016. Clinical and hematological parameters including bone marrow aspiration and biopsy were evaluated in all patients who presented with pancytopenia. Results: Among 138 cases studied, patient’s age ranged from 2 to 82 years with a mean age of 43.95 years, and there was male predominance. Most of the patients presented with generalized weakness, pallor, dypnoea and fever. Hypoplastic marrow was seen in 38(27.5%) cases, followed by megaloblastic anemia 26 (18.8%) cases and acute leukemia 19(13.76%) cases. Other findings included one each case of hemophagocyosis, leishmaniasis, plasmodium vivex malaria and metastatic carcinoma. Conclusions: This study highlights that pancytopenia is a common hematological problem and the study of detailed primary hematological investigations along with bone marrow study in patients with pancytopenia will help to identify the cause for further planning and management. Keywords: hypoplastic marrow; leukemia; megaloblastic anemia; pancytopenia.

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Spectrum of Pancytopenia; A Tertiary Care Experience

Rehmani¹,

Arif²,

Haider³

et al. 2016

TPMJ

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ORIGINAL PROF-3398ABSTRACT… Pancytopenia refers to a reduction in all the three cellular elements of blood. Pancytopenia is a common but important hematological problem encountered in routine clinical Practice. It may be a presenting feature of many underlying serious and life threatening illnesses. Objective: Present study was planned to appraise various clinico-etiological factors underlining Pancytopenia. Study Design: Cross-sectional study. Setting: Hematology Department of Allama Iqbal Medical College/ Jinnah Hospital Lahore (AIMC&JHL). Period: July 2011 to Jun 2015. Materials and Methods: Two hundred and forty four patients with Pancytopenia were included in the study. Complete blood count, bone marrow aspirations and trephine biopsies were performed after clinical history and physical exam. Data were analyzed by using SPSS 20.0 version. Results: Out of total 244 Pancytopenia cases, hypoplastic bone marrow 66 (27.04%) and Megaloblastic anemia 49 (20.08%) were the most common etiological factors with male predominance. Fever and pallor were striking presenting clinical features. Conclusion:We conclude that Pancytopenia is a common problem with an exhaustive list of differential diagnosis, some of which are easily treatable and reversible. Therefore early detection with optimal diagnostic approach to Pancytopenia is required for better management of patients. Key words:Pancytopenia, Aplastic anemia, Megaloblastic anemia, Bone marrow.

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Clinico-hematological study of pancytopenia

Cited by 13 publications

References 0 publications

Pancytopenia: A multidisciplinary assessment of hemato-etiological and clinical spectrum in a tertiary care hospital

Pancytopenia: A multidisciplinary assessment of hemato-etiological and clinical spectrum in a tertiary care hospital

Clinicohematological Study of Pancytopenia in a Tertiary Care Hospital of Western Region of Nepal

Spectrum of Pancytopenia; A Tertiary Care Experience

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