2019
DOI: 10.1007/s10067-019-04770-4
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Clinico-genetic model to predict methotrexate intolerance in rheumatoid arthritis

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Cited by 8 publications
(12 citation statements)
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“…All variables with P <0. 15 were entered into a model using multivariable logistic regression. All tests were done on IBM SPSS Statistics, Version 25.0 (IBM Corp, Armonk, NY, USA).…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…All variables with P <0. 15 were entered into a model using multivariable logistic regression. All tests were done on IBM SPSS Statistics, Version 25.0 (IBM Corp, Armonk, NY, USA).…”
Section: Discussionmentioning
confidence: 99%
“…Two rheumatologists (VD, SN), a fellow (SidJ) and a medicine resident (DV) reviewed previous studies 4‐6,12,13 and our own symptom lists used in prior studies with MTX 14‐16 . Fourteen unpleasant symptoms were included in a preliminary questionnaire for MTX intolerance (Supplementary Figure ).…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…In contrast, the relationship between MTX therapy and pulmonary response to ABA is challenging to explain [ 40 ]. MTX-induced pulmonary toxicity, presented as acute/subacute or rarely as chronic pneumonia, has been a subject of debate for many years [ 41 , 42 ].…”
Section: Discussionmentioning
confidence: 99%
“…We reviewed the single nucleotide polymorphism (SNPs) of these MTX metabolizing pathway genes with a allele frequency of at least 10% and found significant association of adverse events with SNPs, FPGS rs10106 [p = 0.01, OR 2.11, 95% CI (1.20-3.71)] and FPGS rs1544105 [p = 0.02, OR 1.93, 95% CI (1.15-3.35)] [9]. We also developed a model that predicted methotrexate intolerance with an accuracy of 66.3% and used both BMI and FPGS rs10106 as independent (predictor) variables [10]. Moya et al also reported the association of this SNP with MTX toxicity in RA patients [11].…”
Section: Pharmacogenomics and Adverse Eventsmentioning
confidence: 99%