Clinico-epidemiological study of Kaposi's sarcoma in Egypt

El-Haddad, S.; Al-Wahidi, G.F.; Al-Kholi, N.; Al-Shami, Samar; Zaki, O.A.

doi:10.1016/s0009-9260(81)80065-7

Cited by 8 publications

(2 citation statements)

References 15 publications

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“…Limited suc cess was reported by Olweny et al [48] using Rozaxone (ICRF-159). El-Haddad et al [49] showed that cyclophos phamide can be effective, provided it is given after radia tion therapy. Other authors [14,21] failed to demonstrate significant responses with cyclophosphamide.…”

Section: Complicationsmentioning

confidence: 99%

Endemic African Kaposi’s Sarcoma: Clinical and Therapeutic Implications

Stein

Spencer²,

Ruff³

et al. 1994

Oncology

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Endemic African Kaposi’s sarcoma is a common neoplastic disorder in the sub-Saharan region of Africa. We present a retrospective analysis of 47 black patients with the endemic African (HIV-negative) variant of Kaposi’s sarcoma treated and followed up in the Johannesburg General Hospital between 1980 and 1990. Four patients (8%) presented with simultaneous Kaposi’s sarcoma plus malignant lymphoma, indicating a low but significant association with lymphoproliferative disorders. Of 47 patients seen, 29 presented with localized disease and were treated by means of local radiation therapy. Seventeen patients received chemotherapy. The objective response rate was > 80% irrespective of the treatment modality. We conclude that endemic African Kaposi’s sarcoma is a chemo- and radiosensitive tumour.

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Section: Complicationsmentioning

confidence: 99%

Endemic African Kaposi’s Sarcoma: Clinical and Therapeutic Implications

Stein

Spencer²,

Ruff³

et al. 1994

Oncology

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“…In contrast, Egypt appears to be a country with a low incidence of KS. KS represents less than 1% of all the cancers diagnosed in the country and a minority of all skin tumors (27). Thus, the high prevalence of HHV-8 in Egyptian children is not consistent with the low incidence of KS, suggesting that other cofactors play an important role in the pathogenesis of KS in persons who have no known causes of immunosuppression, such as HIV infection or organ transplants.…”

Section: Discussionmentioning

confidence: 99%

High seroprevalence of antibodies to human herpesvirus-8 in Egyptian children: evidence of non-sexual transmission.

Andreoni¹,

El-Sawaf²,

Rezza³

et al. 1999

JAIDS: Journal of Acquired Immune Deficiency Syndromes

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Background: In western countries, human herpesvirus-8 (HHV-8) appears to be transmitted mainly by sexual contact. To evaluate the role of other transmission routes, especially in developing countries, we estimated the seroprevalence of HHV-8 in Egyptian children, who, if seropositive, would have acquired the virus through a nonsexual route. Methods: Sera from 196 children (<1-12 years of age), 20 adolescents (13-20 years of age), and 30 young adults (21-25 years of age) attending a vaccination program in Alexandria, Egypt, were studied. Immunofluorescence assays were used to detect antibodies against HHV-8 lytic-phase antigens (anti-lytic) and latent-phase antigens (anti-latent). Antibodies against Epstein-Barr virus viral cap antigen, cytomegalovirus, and HHV-6 were detected by enzyme-linked immunosorbent assays. Seroprevalence of these herpesviruses was calculated after stratifying the subjects by age. Results: Anti-lytic and anti-latent HHV-8 antibodies were detected in 44.7% and 8.5% of the study participants, respectively. The prevalence of anti-lytic antibodies tended to increase with age, exceeding 50% in children older than 6 years; once children reached the age of 10 years, the prevalence tended to stabilize. The seroprevalence of other herpesviruses tended to be higher than that of HHV-8, ranging from approximately 83% to more than 97% in the 9to 12-year age group. One-to 3-yearold children had higher titers of antilytic HHV-8 antibodies than children in the other age groups. Anti-latent antibodies were more frequently detected in individuals with high anti-lytic antibody titers. Conclusions: HHV-8 antibodies are highly prevalent in Egyptian children, suggesting that, in developing countries, HHV-8 infection may be acquired early in life through routes other than sexual transmission. The lower seroprevalence of HHV-8 relative to that of the other herpesviruses suggests that HHV-8 is less transmissible than other common herpesviruses.

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Kaposi's sarcoma: Report of five cases treated with radiotherapy

Ampil

1986

Journal of Surgical Oncology

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Clinico-epidemiological study of Kaposi's sarcoma in Egypt

Cited by 8 publications

References 15 publications

Endemic African Kaposi’s Sarcoma: Clinical and Therapeutic Implications

Endemic African Kaposi’s Sarcoma: Clinical and Therapeutic Implications

High seroprevalence of antibodies to human herpesvirus-8 in Egyptian children: evidence of non-sexual transmission.

Kaposi's sarcoma: Report of five cases treated with radiotherapy

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