Clinico-Epidemiological Profile and Predictors of Poor Outcome Among Children During a Diphtheria Outbreak in Haryana

Ahmed, Ali; Singh, Manju; Tank, Priyanka; Yadav, Meetu

doi:10.1007/s13312-023-2859-1

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…On the contrary, a study in India with 177 cases of diphtheria showed that leukocytosis only occurred in 8.3% of cases. (14) Almost 60% of current cases were positive for bacterial culture. This finding is similar to a previous study in India which showed that positive culture was only found in 65.6% of cases.…”

Section: Laboratory Findings In Diphtheria Infectionmentioning

confidence: 99%

Clinical And Laboratory Characteristics of Diphtheria Patients Treated at RSUP Haji Adam Malik in 2020 - 2023

Pedia Dinanti,

Rina Ramayani,

Pitaloka Pasaribu

2024

IJRP

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Background: In 2017, diphtheria outbreaks occurred in several provinces in Indonesia. In North Sumatra, data on diphtheria cases are rarely published. Therefore, information is needed to assess the clinical and laboratory characteristics that are associated with an increase in mortality of diphtheria. This study aims to determine the clinical dan laboratory profile of children with Diphtheria Methods: Retrospective cohort study to assess the association of clinical and laboratory characteristics with mortality. Research data was obtained from medical records of patients aged 1-18 years diagnosed with diphtheria clinically at H. Adam Malik Hospital Medan in the period January 2020 to December 2023. Results: The majority of children with diphtheria were male (56,8%) and the mean age of 8,14. Most patients did not receive any immunization for diphtheria (54,1%). During this period, the mortality rate was 16,2%. All participants experienced fever and sore throat. Pseudo-membrane was found in 36 cases (97.3%) followed by bullneck appearance (73%) and myocarditis (45,9%). Leukocytosis was found in 78,4% of cases while positive bacterial culture and thrombocytopenia were found in 59.5% and 51.4% of the cases Conclusions: The clinical profile of Diphtheria at Haji Adam Malik Hospital Medan showed that all cases with fever and sore throat, most of cases had pseudo-membrane, bullneck, and myocarditis. Leukocytosis, bacterial culture and thrombocytopenia showed over half of the cases.

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Section: Laboratory Findings In Diphtheria Infectionmentioning

confidence: 99%