Clinico-epidemiological characteristics of men and women with a new diagnosis of chronic obstructive pulmonary disease: a database (SIDIAP) study

Abstract

Background The risk of developing Chronic Obstructive Pulmonary Disease (COPD), the associated comorbidities and response to bronchodilators might differ in men and women. The objective of this study was to determine the prevalence of COPD and the clinic-epidemiological characteristics of primary care patients with COPD according to gender. Methods This is a cross-sectional study using electronic healthcare records Catalonia (Spain), during the 01/01/2012–31/12/2017 period. Patients from the SIDIAP database (System for the Development of Research in Primary Care) were included (5,800,000 patients registered in 279 primary care health centres). Clinic-demographic characteristics, comorbidities and blood tests results were collected for each patient. Adjusted OR (ORa) with logistic regression methods were used to determine variables associated with men and women. Results From an initial sample of 800,899 people, 24,135 (3%) were considered COPD patients, and 22.9%were women. The most common risk factors in women were bronchiectasis (ORa = 20.5, SD = 19.5–21.6), age > 71 years (ORa = 18.8; SD = 17.3–20.5), cor pulmonale (ORa = 5.2; SD = 4.3–6.7) and lung cancer (ORa = 3.6, SD = 3.2–4.0). Men and women presented the same comorbidities, though the strength of association was different for each gender. Conclusions Patients suffering high comorbidity rates. Comorbidities are similar in men and women, although the strength of association varies according to gender. Women are more susceptible to the harmful effects of smoking and present a higher proportion of bronchiectasis and OSAS.

Sex differences in comorbidities and mortality risk among patients with chronic obstructive pulmonary disease: a study based on NHANES data

“…R. W. Dal Negro et al showed that congestive heath failure was more prevalent among females [ 18 ]. Among cardiometabolic conditions, hypertension, congestive heart failure, angina pectoris, and stroke prevalence did not differ between sexes in the present study, even though a previous report showed a higher morbidity among men [ 10 , 19 , 20 ]. Another study showed that the morbidity of cardiovascular disease was similar between female and male patients with COPD [ 21 ].…”

“…This study evaluated the prevalence of different comorbidities among participants with COPD by sex and determined the difference in survival between males and females with COPD in a large nationally representative dataset in the United States. Assessing sex differences in COPD-related comorbidities might assist us in developing better management strategies, thereby contributing to a reduced impact and a substantial improvement in patient quality of life [ 10 ].…”

The Human Microbiome, an Emerging Key-Player in the Sex Gap in Respiratory Diseases

“…In adulthood, a sex-based difference is also observed in COPD with regard to clinicoradiographic phenotype, symptom severity, and quality of life. Female patients are more sensitive to the adverse effects of smoking, have more symptoms such as dyspnea or cough, and have a higher proportion of bronchiectasis (3,21,22).…”

Prevalence of Pulmonary Embolism and Deep Venous Thromboembolism in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis

“…Age is a risk factor for VTE, with a high incidence in patients aged ≥ 70 years old ( 60 , 61 ). For women, the risk of developing COPD increased by 4.7 aged 61–70 years old and 14.5 after 80 years old ( 62 ). Moreover, the mortality increased with age ( 63 ).…”