Clinico-Biochemical Correlation to Histological Findings in Alcoholic Liver Disease: A Single Centre Study from Eastern India

Ray, Sayantan; Khanra, Dibbendhu; Sonthalia, Nikhil; Kundu, Supratip; Biswas, Kaushik; Talukdar, Arunansu; Saha, Manideepa; Bera, Himel

doi:10.7860/jcdr/2014/8763.4968

Cited by 10 publications

(11 citation statements)

References 14 publications

(17 reference statements)

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“…Similar results were obtained in a study conducted by Pathak et al among patients of alcoholic liver disease and found that male preponderance was highly prevalent and majority of patients were farmers which is followed by employed at private service and daily wages workers (11). Similar results were obtained in a study conducted by Ray et al among patients of alcoholic liver disease and found that majority of the patients had alcohol consumption of more than 80 grams per day and also consumed poor quality of liquor for a mean duration 9 years and more (12).…”

Section: Discussionsupporting

confidence: 69%

Assessment of Clinical Profile of Patients With Alcoholic Liver Disease

Nayak

2019

IJMBS

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Background: Alcohol consumption affects both mental and physical function of the body and hence called as "dual disease" because it has mentioned in etiology of morbidity in both the components of the body. According to the reports of World Health Organization there were more than 150 million people worldwide has indulged with alcoholism. Material & Methods:The present prospective study was conducted at department of general medicine of our tertiary care hospital. 100 Patients who were diagnosed as acute onset alcoholic liver disease were enrolled from outdoor and from ward by simple random sampling. Results: The most common clinical feature recorded among study participants was of nausea and vomiting seen in 46 (92%) of patients, which was followed by jaundice reported among 43 (86%) of patients. Hepatomegaly was reported among 37 (74%) of patients, which was followed by signs of liver failure reported among 30 (60%) patients, followed by anorexia reported among 29 (58%) of patients. Splenomegaly was reported among 17 (34%) of patients, fever was reported among 13 (26%) of patients, abdominal pain was reported among 12 (24%) of cases and ascites was reported among 8 (16%) study participants. Conclusion:We concluded from the present study that larger quantities of alcohol consumption for a longer duration of time result in high morbidity and mortalities. Alcoholic liver disease is not only a medical burden but also a social burden which leads to frequent hospitalization and unwanted out of pocket expenditure.

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Section: Discussionsupporting

confidence: 69%

Assessment of Clinical Profile of Patients With Alcoholic Liver Disease

Nayak

2019

IJMBS

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“…15 Ray et al reported jaundice and hepatomegaly as the most commonly observed clinical findings. 16 Haemetemesis or melena was reported in 30% of total ALD patients in our study and anorexia was noted as the most common symptom in our study. Pathak et al reported jaundice as the most common presentation, which was present in 57.5% (104) of their patients, followed by hepatomegaly (48.6%), ascites (45.3%) and edema (36.5%).…”

Section: Clinical Featuressupporting

confidence: 55%

“…Intake of poor quality country liquor was noted among their study group. 16 In present study majority (66.6%) of the patients had been consuming alcohol for more than 5 years and most of them were consuming whisky, scotch, rum and beer. Nand et al observed that majority of them (79%) were consuming country-made spirits.…”

Section: Amount and Duration Of Alcohol Consumptionmentioning

confidence: 49%

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Study of clinical and biochemical profile of acute alcoholic liver disease in a teaching hospital in Telangana

Khatroth

2018

Int J Adv Med

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Background: Chronic alcohol consumption gives rise to various health risks that include liver disease, heart disease, pancreatitis, central nervous system disorders and certain forms of cancer. Alcoholic liver disease (ALD) is a spectrum of clinicopathological abnormalities, reflecting an acute or chronic inflammation of the liver parenchyma induced by alcohol use. It is associated with changes in various biochemical parameters and also various clinical manifestations in the patients. The objective of the present study to evaluate clinical and biochemical profile of acute alcoholic liver disease.Methods: The prospective hospital-based case control study was done at MNR Medical College, in the department of General Medicine for duration of one year from March 2017 to April 2018. A total of 120 cases diagnosed clinically and biochemically as Acute alcoholic liver disease were included in the study.Results: The age group ranged from 20 to 60 years and the male to female ratio was 2.42. Majority of the patients were in the age group of 30-40 years (54.1%). Majority of the patients (66.6%) consumed >60 grams/24hours of alcohol. Jaundice, nausea and vomiting were seen in 83.3% cases followed by hepatomegaly in 66.6% cases. Majority of them had been consuming alcohol for more than 5 years.Conclusions: Chronic alcohol consumption is more common in adult males. Chronic alcoholics consume more amount of alcohol. Alcoholic liver disease has a varied clinical presentation and is associated with deranged biochemical parameters.

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“…Other studies could also explain this low incidence of AC as an indication for LT in our female population (Amarapurkar and Amarapurkar, ; Becker et al., ; Morgan and Sherlock, ). Nevertheless, Ray and colleagues () observed that age and sex did not seem to be correlated with quantity and duration of alcohol consumption in the population of India. Therefore, another possible explanation is that women are more prone to the hepatotoxic effect of alcohol (Erol and Karpyak, ; Frezza et al., ; Norberg et al., ) and begin treatment for alcohol dependence when the first symptoms of liver damage appear.…”

Section: Discussionmentioning

confidence: 98%

Epidemiology, Evolution, and Long‐Term Survival of Alcoholic Cirrhosis Patients Submitted to Liver Transplantation in Southeastern Spain

Legáz

Navarro-Noguera

Bolarín

et al. 2016

Alcoholism Clin & Exp Res

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AC without viral infections is the main indication for LT in southeastern Spain although its frequency has decreased in last decade. AC is a good indication for LT for its high survival rate and few posttransplant complications. Despite having a high percentage of pretransplant complications (ascites and encephalopathy) but does not appear to influence survivals being observed posttransplant survival rates above those expected. Conversely, viral infections in the patient with AC decrease patient survivals. The main future goals are design new strategies to detect, treat, and reduce AC frequency in our population and know alcoholic recidivism rate posttransplant in our population.

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Clinico-Biochemical Correlation to Histological Findings in Alcoholic Liver Disease: A Single Centre Study from Eastern India

Cited by 10 publications

References 14 publications

Assessment of Clinical Profile of Patients With Alcoholic Liver Disease

Assessment of Clinical Profile of Patients With Alcoholic Liver Disease

Study of clinical and biochemical profile of acute alcoholic liver disease in a teaching hospital in Telangana

Epidemiology, Evolution, and Long‐Term Survival of Alcoholic Cirrhosis Patients Submitted to Liver Transplantation in Southeastern Spain

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