Clinico-bacteriological study of neonatal septicemia in Hubli

Tallur, Shashikala S.; Kasturi, Ashwin; Nadgir, Shobha D; Krishna, Bhuvana

doi:10.1007/bf02723654

Cited by 150 publications

(176 citation statements)

References 14 publications

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“…Third generation cephalosporin resistance is now rampant and has been widely reported by recent studies. 3,4,7,8,10,15,16,17 Ceftizoxime revealed better sensitivity pattern against Pseudomonas aeruginosa (57%) in index study when compared to a recent study (25%). 18 Pseudomonas was sensitive to ciprofloxacin in only 47% isolates in our study as against reported sensitivity of 75% by Kumhar. 12 Recent studies reported increased resistance of Pseudomonas to ciprofloxacin varying from 10% to 40.8%.…”

Section: Discussionmentioning

confidence: 59%

Bacteriological profile and antimicrobial sensitivity pattern in neonatal sepsis: a study from North India

et al. 2017

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Background: Neonatal sepsis is a leading cause of neonatal mortality and continues to be a formidable problem for neonatologists and pediatricians world over. Knowledge of microbial flora and their susceptibility will help us to decide empirical treatment for the neonatal sepsis. The objective of this study was to determine the bacteriological flora prevalent in NICU and the antimicrobial sensitivity pattern.Methods: The blood culture reports of all the neonates with culture proven neonatal sepsis during the period July 2010 to September 2013 were reviewed retrospectively. A retrospective review in tertiary care teaching medical college. The data was entered in Excel sheets and percentages of various outcomes were calculated.Results: A total of 28,927 babies were born during the study period and 336 among them had positive blood culture. The incidence of neonatal sepsis was 11.62 per 1,000 live births. Three hundred fifty- six microbes were isolated, out of which 50% presented as early onset sepsis and remaining as late onset sepsis. Pseudomonas aeruginosa was the most common organism encountered in both early (43.82%) and late onset sepsis (51.35%). Gram negative bacilli were sensitive to carbapenems (92%) followed by piperacillin-tazobactam (90%) whereas linezolid (90%) was most sensitive antimicrobial for gram positive cocci.Conclusions: Pseudomonas was most commonly isolated in both early and late onset sepsis. Gram negative bacilli were most sensitive to piperacillin-tazobactam and the carbapenems whereas linezolid and vancomycin were most effective against the gram-positive cocci. Resistance to third generation cephalosporins was rampant. Continuous surveillance for microbial flora, their antibiotic susceptibility, rational use of antibiotics and the strategy of antibiotic cycling may be of help to curtail emerging antimicrobial resistance.

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Section: Discussionmentioning

confidence: 59%

Bacteriological profile and antimicrobial sensitivity pattern in neonatal sepsis: a study from North India

et al. 2017

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“…Fungal, rickettsial, protozoal and viral infections also cause thrombocytopenia [6]. As this study was done only for bacterial isolate, there might be other cause as mentioned above may be associated with thrombocytopenia which did not show bacterial growth.…”

Section: Discussionmentioning

confidence: 89%

“…aureus, Staph. epidermidis, Group B Streptococci, Enterococcus faecalis, Entrobacter sp., Acinetobacter sp., Pseudomonas sp., Proteus sp., Citrobacter seen in developing countries [2,[5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Thrombocytopenia and Bacterial Sepsis in Neonates

Arif

Ahmad

Ali

et al. 2011

Indian J Hematol Blood Transfus

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Thrombocytopenia is one of the common hematological problems encountered in the neonatal period particularly in the sick newborns, premature babies and neonates admitted in neonatal intensive care units and usually indicate an underlying pathologic process. Thrombocytopenia is reported in neonates with bacterial, fungal, rickettsial, protozoal and viral infection. Some patients with bacterial septicemia may develop coagulopathy associated with DIC. The presence of thrombocytopenia is seen frequently in early sepsis with or without laboratory evidence of overt DIC. This study was conducted on 85 neonates admitted in NICU with clinical diagnosis of septicemia and 50 age and weight matched neonates served as control. Thrombocytopenia was seen in 83.5% cases where as bacterial culture was positive in only 41.1% cases. Further it was noted that, in gram negative (Gm -ve) septicemia, thrombocytopenia was more severe as compared to gram positive (Gm ?ve) septicemia. It is concluded that thrombocytopenia is early predictor of septicemia but other causes of neonatal thrombocytopenia should also be ruled out.

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“…The most commonly seen clinical feature of neonatal sepsis was respiratory distress which was also associated in some cases with grunting in the study of Ghosh et al [14] , Tallur et al [20] also noted in their studies that cardiorespiratory signs are the commonest form of presentation. Other clinical features found in our study were jaundice, fever, vomiting and CNS symptoms which is affirmed by the study of Mohammad f. Ibraheem.…”

Section: Clinical Presentationmentioning

confidence: 99%