Clinico-bacteriological profile of neonatal sepsis in rural tertiary care hospital

Abstract

Background: Neonatal sepsis one of the most common cause for neonatal mortality and morbidity in developing countries. Group B Streptococci being the most common organism in developed countries, whereas CONS and Gram negative bacteria frequently encountered organisms in developing countries. It is advisable to have an individualised institutional protocol based on their own culture reports to reduce the antibiotic resistance.Methods:A prospective observational study was conducted from September 2016- February 2017, at the Department of Paediatrics, S.V.S. Medical College and Hospital, Mahabubnagar, Telangana, India. The study included 65 neonates admitted in our NICU. A questionnaire was filled by mothers after taking consent. Data was Collected data was analysed.Results: In present study, we found that CONS were the most commonly isolated organisms followed by Klebsiella.Conclusions:Neonatal sepsis creates a significant burden due to its impact on neonatal mortality and long-term morbidity. Following proper hand washing techniques with minimal handling in intensive care units will reduce neonatal sepsis from opportunistic infections.

Clinico-bacteriological profile of neonatal sepsis

“…The blood culture positivity in neonates with clinical suspicion of sepsis was 26.57% during the given study period which was similar to study done by Roy et al 11 It was only 18% in Bhat et al study 4 and was higher (42.8%) in a study done in Egypt by Moshen et al 12 Half of the neonates in present study, presented with respiratory symptoms, identical to studies done by Jain et al and Galhotra et al 13,14 Contrary to this, 72% presented with poor activity / poor cry in Reddy K V et al, study. 15 The most common type of sepsis in present study was EOS which is in parallel to studies by Galhotra et al, and Madavi et al 14,16 Opposite to this, studies done in India by Goyal et al, and his associates and by Ozkal et al, in Turkey showed LOS as common sepsis type. 17,18 Late onset sepsis occurs usually in neonates with prolonged hospital stay, especially in low birth weight and preterm neonates.…”

Hematological Profile of Newborns Hospitalized for Neonatal Bacterial Infection in the Neonatology of the Pediatric Department of Gabriel Toure Teaching Hospital Bamako, Mali

“…In our sample, the sex ratio was 1.4; this predominance of the male sex has been found in several studies [7] A large number of newborns (93.8%) were symptomatic before their first day of life. In literatures, the first clinical manifestations of neonatal bacterial infection very generally appear before the 72nd hour of life.…”

“…As a result, the diagnosis of bacterial neonatal infections is based on bundles of clinical arguments and laboratory examinations including standard microbiological tests (blood, cerebrospinal fluid and urine), hematological and biochemical tests. In developed countries, the identification of the pathogen by blood cultures which confirms the clinical diagnosis has a high specificity [7] [8]. This is not the case in developing countries [7].…”

“…In developed countries, the identification of the pathogen by blood cultures which confirms the clinical diagnosis has a high specificity [7] [8]. This is not the case in developing countries [7]. The complete blood count and different leukocyte dosages have relatively variable specificity for the diagnosis of bacterial neonatal infection.…”