Clinically translatable quantitative molecular photoacoustic imaging with liposome-encapsulated ICG J-aggregates

Wood, Cayla; Han, Sangheon; Kim, Chang Soo; Wen, Yunfei; Sampaio, Diego R. T.; Harris, Justin T.; Homan, Kimberly A.; Swain, Jody; Emelianov, Stanislav; Sood, Anil K.; Cook, Jason R.; Sokolov, Konstantin V.; Bouchard, Richard R.

doi:10.1038/s41467-021-25452-3

Cited by 80 publications

(72 citation statements)

References 69 publications

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“…have also been reported for PA imaging in tumor model mice. The nanocarriers can be further conjugated with antibodies for specific tumor targeting, which boosts the efficacy and quantification of PA imaging, making it a promising candidate for future clinical applications [ 74 ].…”

Section: Utilization Of Dye Aggregates For Biomedical Applicationsmentioning

confidence: 99%

Interfacing DNA nanotechnology and biomimetic photonic complexes: advances and prospects in energy and biomedicine

2022

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Self-assembled photonic systems with well-organized spatial arrangement and engineered optical properties can be used as efficient energy materials and as effective biomedical agents. The lessons learned from natural light-harvesting antennas have inspired the design and synthesis of a series of biomimetic photonic complexes, including those containing strongly coupled dye aggregates with dense molecular packing and unique spectroscopic features. These photoactive components provide excellent features that could be coupled to multiple applications including light-harvesting, energy transfer, biosensing, bioimaging, and cancer therapy. Meanwhile, nanoscale DNA assemblies have been employed as programmable and addressable templates to guide the formation of DNA-directed multi-pigment complexes, which can be used to enhance the complexity and precision of artificial photonic systems and show the potential for energy and biomedical applications. This review focuses on the interface of DNA nanotechnology and biomimetic photonic systems. We summarized the recent progress in the design, synthesis, and applications of bioinspired photonic systems, highlighted the advantages of the utilization of DNA nanostructures, and discussed the challenges and opportunities they provide. Graphical Abstract

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Section: Utilization Of Dye Aggregates For Biomedical Applicationsmentioning

confidence: 99%

Interfacing DNA nanotechnology and biomimetic photonic complexes: advances and prospects in energy and biomedicine

2022

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“…Tracking drug concentration in real time is critical to adjusting the in vivo drug-release rate and optimal concentration for treatment. NIR fluorescence imaging techniques, including the PA method, can provide real-time tracking of drug delivery by taking advantage of the deep tissue penetration, high contrast, and decreased background auto-fluorescence interference [ 231 ]. The monitoring of drug concentration by directly tracking drug molecules with radionuclides or fluorochromes prior to entrapment by NMs might be a promising strategy for semi-quantitatively detecting active drug release in a non-invasive manner.…”

Section: Nano-pharmaceutical Evaluations Under the Bioimaging Guidancementioning

confidence: 99%

Bioimaging guided pharmaceutical evaluations of nanomedicines for clinical translations

Tuguntaev

Hussain

et al. 2022

J Nanobiotechnol

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Nanomedicines (NMs) have emerged as an efficient approach for developing novel treatment strategies against a variety of diseases. Over the past few decades, NM formulations have received great attention, and a large number of studies have been performed in this field. Despite this, only about 60 nano-formulations have received industrial acceptance and are currently available for clinical use. Their in vivo pharmaceutical behavior is considered one of the main challenges and hurdles for the effective clinical translation of NMs, because it is difficult to monitor the pharmaceutic fate of NMs in the biological environment using conventional pharmaceutical evaluations. In this context, non-invasive imaging modalities offer attractive solutions, providing the direct monitoring and quantification of the pharmacokinetic and pharmacodynamic behavior of labeled NMs in a real-time manner. Imaging evaluations have great potential for revealing the relationship between the physicochemical properties of NMs and their pharmaceutical profiles in living subjects. In this review, we introduced imaging techniques that can be used for in vivo NM evaluations. We also provided an overview of various studies on the influence of key parameters on the in vivo pharmaceutical behavior of NMs that had been visualized in a non-invasive and real-time manner. Graphical Abstract

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“…Besides the light induced emission and chemical reaction processes, the light induced acoustic (photoacoustic) is also considered to be one of the most essential characters of the light absorbing molecules. [4][5][6] Though, a few studies have found aggregation related PA enhancement, for instance, in the case of J aggregation induced new absorption band, 7 the formation of the large size cluster of nanoparticles or molecules. 8,9 To the best of our knowledge, the molecular aggregation induced photoacoustic effect (MAIPA) for which decoupling from the absorbance and size increasement effect has never been reported.…”

Section: Introductionmentioning

confidence: 99%

Molecular Aggregation Induced Photoacoustics for NIR-II in vivo Imaging

Chang

Liu

et al. 2022

Preprint

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Molecular aggregation induced photo-properties alteration has been found to play a crucial role in the light induced processes, such as aggregation induced emission (AIE) and J aggregation induced dramatic absorption red shift. The light induced acoustic process (photoacoustic) is also considered to be one of the most essential characters of the light absorbing molecules. However, to the best of our knowledge, the molecular aggregation induced photoacoustic effect (MAIPA) has never been reported. Herein, we report the first MAIPA effect for which the PA intensity is dominated by the molecular aggregation, rather than by absorbance as usual concerned. Molecular aggregation induces a strong electronic coupling effect, resulting in significant absorption suppression from the individual state to highly aggregated state (around 5 molecules aggregated). However, the corresponding PA efficiency was found to be about 2-orders of magnitude greater for the latter. A well-behaved linear correlation between the molecular aggregation level and MAIPA effect was observed. The surprisingly significant MAIPA effect was realized via novel NIR-II squaraine-benzothiopyrylium dyes. Excellent photophysical properties of the novel NIR-II dyes were achieved, such as large absorption extinction coefficient and high photostability. Thanks to the relatively narrow FWHM and the high PA efficiency of SQN2@PMAOPEG and ZC825@BSA, in vivo multiplex PA imaging was demonstrated for tumor tissue and macrophage cells, blood and lymphoid vessels.

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Clinically translatable quantitative molecular photoacoustic imaging with liposome-encapsulated ICG J-aggregates

Cited by 80 publications

References 69 publications

Interfacing DNA nanotechnology and biomimetic photonic complexes: advances and prospects in energy and biomedicine

Interfacing DNA nanotechnology and biomimetic photonic complexes: advances and prospects in energy and biomedicine

Bioimaging guided pharmaceutical evaluations of nanomedicines for clinical translations

Molecular Aggregation Induced Photoacoustics for NIR-II in vivo Imaging

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