Clinically suspected myocarditis in COVID‐19 patients: Case series and review of the literature

Amin, Ahmad; Eftekhar, Seyed Parsa; Ziaie, Naghmeh; Roudbari, Soudeh; Salehi, Pegah; Jalali, Farzad; Jafaripour, Iraj; Ghaffari, Sanaz; Salehi, Maryam; Ebadi, Reza

doi:10.1002/ccr3.5236

Cited by 7 publications

(4 citation statements)

References 23 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Li et al mentioned that pneumonia induced by SARS-CoV-2 infection results in critical gas exchange obstruction, causing hypoxemia. This hypoxic state decreases the energy supply by cell metabolism, which results in increasing anaerobic fermentation, intracellular acidosis, and oxygen-free radical formation, and finally damaging the phospholipid layer of the cell membrane [ 4 ]. To investigate whether hypoxia induced the NT-proBNP up-regulation, we evaluated the patient’s SpO 2 saturation at admission time and NT-proBNP concentrations.…”

Section: Discussionmentioning

confidence: 99%

“…However, cTnI, CPK-MB, and NT-proBNP/BNP are cardiac biomarkers, specifically showing myocardial injury, and are reported to increase, especially in severe COVID-19 patients in the Intensive Care Unit (ICU) [ 3 ]. Cardiac involvement consists of different presentations such as arrhythmia, myocarditis, cardiogenic shock, acute myocardial injury, and heart failure with variable severity [ 4 ]. In another study on 138 patients with COVID-19, 7.2% and 16.7% of the subjects suffered from acute cardiac injury and arrhythmia, respectively.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Optimal cut points of N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) in patients with COVID-19

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background COVID19 patients may suffer from multiple cardiovascular complications. Recently, N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) was a potentially independent risk factor for COVID-19 in-hospital death. The present study aimed to find new optimal cut points for NT-proBNP across censored survival failure time outcomes in hospitalized COVID-19 patients. Results This cohort study was conducted on 272 patients with COVID-19 whose initial records were recorded from March 2020 to July 2020. Demographic characteristics, clinical examinations, and laboratory measurements were collected at the beginning of the admission registered in the patient record system located in the hospital. We used the maximally selected rank statistics to determine the optimal cut points for NT-proBNP (the most significant split based on the standardized log-rank test). Survival time was defined as the days from hospital admission to discharge day. In this cohort study, two optimal cut points for NT-proBNP were 331 (pg/mL) and 11,126 (pg/mL) based on a survival model. The adjusted HR of NT-proBNP for in-hospital death was 3.41 (95% CI: 1.22–9.51, P = 0.02) for medium against low category, and 3.84 (95% CI: 1.30–11.57, P = 0.01) for high in comparison with low group. Conclusions We reported a dramatically increased concentration of NT-proBNP among COVID-19 patients without heart failure in both severe and non-severe cases. Moreover, our study showed that a high level of NT-proBNP was highly associated with the prolonged survival time of patients with COVID-19. NT-proBNP is a strong prognostic indicator of in-hospital death in the second week of admission.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Optimal cut points of N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) in patients with COVID-19

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Although the exact relationship between risk factors and post-COVID-19-syndrome-associated myocarditis has not yet been discovered, most patients who showed signs and symptoms of myocarditis had a past medical history of hypertension, obesity, diabetes mellitus [ 57 ], chronic kidney disease, chronic obstructive pulmonary disease, asthma, chronic liver disease, cerebral vascular accidents, coronary artery disease, and structural heart disease [ 58 ]. Some of the common risk factors of myocarditis in patients with long COVID syndrome have been shown in Figure 1 .…”

Section: Reviewmentioning

confidence: 99%

Myocarditis and Myocardial Injury in Long COVID Syndrome: A Comprehensive Review of the Literature

Paruchuri,

Farwa,

Jabeen

et al. 2023

Cureus

View full text Add to dashboard Cite

The repercussions of coronavirus disease 2019 (COVID-19) have been devastating on a global scale. Long COVID, which affects patients for weeks or even months after their initial infection, is not limited to individuals with severe symptoms and can affect people of all ages. The condition can impact various physiological systems, leading to chronic health conditions and long-term disabilities that present significant challenges for healthcare systems worldwide. This review explores the link between long COVID and cardiovascular complications such as myocardial injury and myocarditis. It also highlights the prevalence of these complications and identifies risk factors for their development in long COVID patients. Myocardial injury occurs due to direct cellular damage and T-cell-mediated cytotoxicity resulting in elevated cardiac biomarkers. Diagnostic techniques like electrocardiogram, troponin level testing, and magnetic resonance imaging can help identify myocarditis, but endomyocardial biopsy is considered the gold-standard diagnostic technique. Guideline-directed medical therapy is recommended for COVID-19 myocarditis patients for better prognosis while being monitored under comprehensive care management approaches. Therefore, it's critical to develop effective screening techniques specifically for vulnerable populations while conducting further research that addresses the effects of long COVID on society's physical health.

show abstract

“…Other biomarkers that are directly indicative of myocardial damage are B-Type Natriuretic Peptide (BNP) and N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) which are shown to markedly increase in patients with severe COVID-19 infection brought into Intensive Care Unit (ICU) (8). Signs of cardiac damage manifests in, arrhythmia, myocardial injury and mild to severe heart failure (9).…”

Section: Introductionmentioning

confidence: 99%

The impact of COVID-19 on BNP, NT-proBNP and ANP in heart failure

Rawaz D. Tawfeeq,

Mohammed H. Alwan,

Ava T. Ismael

et al. 2023

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

Clinically suspected myocarditis in COVID‐19 patients: Case series and review of the literature

Cited by 7 publications

References 23 publications

Optimal cut points of N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) in patients with COVID-19

Optimal cut points of N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) in patients with COVID-19

Myocarditis and Myocardial Injury in Long COVID Syndrome: A Comprehensive Review of the Literature

The impact of COVID-19 on BNP, NT-proBNP and ANP in heart failure

Contact Info

Product

Resources

About