Clinically Significant Minor Blood Group Antigens amongst North Indian Donor Population

Abstract

Background. Racial differences in blood group antigen distribution are common and may result in striking and interesting findings. These differences in blood group antigen distribution are important due to their influence on the clinical practice of transfusion medicine. Study Design and Methods. This is a prospective study, involving 1000 healthy regular repeat voluntary blood donors associated with the department. The clinically significant minor blood group antigens of these donors were studied. Results. Out of 1000 healthy regular repeat voluntary blood donors, 93% were D positive and 2.8% were K positive. Amongst the Rh antigens, e was the most common (99%), followed by D (93%), C (85.1%), c (62.3%), and E (21.5%). Within the MNS blood group system, antigen frequency was M (88%), N (57.5%), S (57.8%), and s (87.5%). Within the Duffy blood group system, antigen frequency was Fya (87.3%) and Fyb (58.3%). Conclusions. This data base will help us to prevent alloimmunisation in young females, pregnant women, and patients who are expected to require repeated transfusions in life by providing them with antigen matched blood. Antigen negative blood can also be made available without delay to already alloimmunized multitransfused patients.

Frequencies of red blood cell major blood group antigens and phenotypes in the Chinese Han population from Mainland China

“…Besides ABO and Rh antibodies, antibodies to other clinically significant antigens are also known to cause HTR, HDFN or shortened survival of transfused red cells (Poole & Daniels, 2007;Lamba et al, 2013). Knowledge of these clinically significant antigens can help not only in the prevention and appropriate management of pregnancies at risk of HDFN and multitransfused patients with alloimmunization, but also in the availability of in-house red cell panels for antibody screening and identification.…”

“…Knowledge of these clinically significant antigens can help not only in the prevention and appropriate management of pregnancies at risk of HDFN and multitransfused patients with alloimmunization, but also in the availability of in-house red cell panels for antibody screening and identification. The frequency of such antigens is available for Indian, Caucasian and Black populations (Thakral et al, 2010;Reid et al, 2012;Lamba et al, 2013). Only very limited data are available about RBC antigen and phenotype frequencies in the Chinese population in Mainland China (Liu et al, 2003;Yan et al, 2003;Luo et al, 2008a,b;Zhu et al, 2012;Jiao et al, 2014;Wang et al, 2014).…”

“…Such a donor bank would be extremely useful for mainland Chinese patients with a rare phenotype, individuals with multiple antibodies, for example multi-transfused patients (Daniels, 2009(Daniels, , 2013Flôres et al, 2014), and to prevent alloimmunization in susceptible individuals such as young or pregnant females and patients who are expected to require repeated transfusions in life, such as refractory aplastic anaemia, thalassaemia or sickle cell disease patients (Diedrich et al, 2001;Lamba et al, 2013). The current practice of providing compatible blood to patients in the majority of transfusion compatibility testing laboratories in mainland China is currently only achieved by random cross matching of available units in the inventory.…”

“…Therefore, it is important to carry out antigen typing to establish a donor bank of known phenotypes for the mainland Chinese population. Such a donor bank would be extremely useful for mainland Chinese patients with a rare phenotype, individuals with multiple antibodies, for example multi-transfused patients (Daniels, 2009(Daniels, , 2013Flôres et al, 2014), and to prevent alloimmunization in susceptible individuals such as young or pregnant females and patients who are expected to require repeated transfusions in life, such as refractory aplastic anaemia, thalassaemia or sickle cell disease patients (Diedrich et al, 2001;Lamba et al, 2013).…”

Presence of Irregular Antibody (Anti-c) in a Multitransfused Cardiac Surgery Patient

“…Rh c antigen is comparatively common in India with frequency ranging from 52 to 62 % of Indian population [12][13][14][15][16], meaning thereby that finding Rh c antigen negative blood units is not an easy task. Resolution of such incompatibility issues and finding of implicated antigen negative blood units is time consuming, and jeopardizes transfusions in case of emergencies.…”