Clinically Significant? Depends on Whom You Ask

Response to Open Peer Commentaries on “Genomic Inheritances: Disclosing Individual Research Results From Whole-Exome Sequencing to Deceased Participants’ Relatives”

“…Enhancing the quality of disclosure, e.g., in terms of timeliness and intelligibility, so as to maximize benefit to relatives (Costain and Bassett 2012; Fullerton et al 2012; Johnson et al 2012). …”

“…Facilitating the design of disclosure plans that are tailored to the population, duration, and analytic targets of a particular study (Blasimme et al 2012; Johnson et al 2012). …”