Clinically Relevant Pancreas-Related Infectious Complication After Pancreaticoenteral Anastomosis Could Be Predicted by the Parameters Obtained on Postoperative Day 3

Abstract

In view of the clinical variables obtained on POD3, such as amylase levels in drain effluent, body temperature, and leukocyte count, clinically relevant pancreas-related infections could be predicted well.

Perioperative albumin ratio is associated with post‐operative pancreatic fistula

“…6 Other series suggested different cut-off levels as risk factors, demonstrating that a common value is not actually widely accepted. [17][18][19] We considered an amylase content greater than three times the serum amylase activity, according to ISGPS definition of fistula; 10 furthermore, this threshold is validated as cut-off value for drainage removal after pancreatoduodenectomies. On the contrary, POD3 amylase level in drainage fluid, higher than three times the upper normal serum amylase level, was an independent predictive factor for POPF.…”

Multivariate logistic regression analysis for prediction of clinically relevant pancreatic fistula in the early phase after pancreaticoduodenectomy

“…Recently, Kawai et al has reported that the early removal of drains on post-operative day (POD) 4 can reduce intraabdominal infections in patients without symptoms of PF [6]. Moreover, some reports have proposed predictors for the incidence of PF [7][8][9][10][11][12][13]. However, unexpected intraabdominal abscesses are occasionally caused by latent PF and the accuracy of the management of drains still remains unsatisfactory.…”

Effect of Perioperative Synbiotic Treatment on Bacterial Translocation and Postoperative Infectious Complications after Pancreatoduodenectomy

“…Postoperative infectious complications (POICs) frequently occur following PD. Pancreatic fistula is the most commonly observed complication following PD, and in many cases, it may accompany infectious complications due to bacterial contamination of the peri-anastomotic tissues [2] . Preventing the occurrence of infectious complications is crit-ical in reducing other postoperative morbidities, mortality, and the postoperative hospital stay.…”