Clinically relevant anxiety and risk of Alzheimer's disease in an elderly community sample: 4.5 years of follow-up.

Santabárbara, Javier; Villagrasa, Beatriz; López-Antón, Raúl; Olaya, Beatriz; Bueno-Notivol, Juan; Cámara, Concepción de la; Gracia-García, Patricia; Lobo, Elena; Lobò, Antonio

doi:10.1016/j.jad.2019.02.050

Cited by 36 publications

(21 citation statements)

References 26 publications

(24 reference statements)

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“…The methodology of ZARADEMP has been previously described [12][13][14][15]. Briefly, a random sample of community-dwelling people aged 55 years or older was proportionally drawn by age and sex from the census list of Zaragoza (Spain).…”

Section: Sample and Proceduresmentioning

confidence: 99%

Association between Anxiety and Vascular Dementia Risk: New Evidence and an Updated Meta-Analysis

Santabárbara

Lipnicki

Olaya

et al. 2020

JCM

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The association between anxiety and vascular dementia (VaD) is unclear. We aimed to reliably estimate the association between anxiety and VaD risk using meta-analysis to pool new results from a large community-based cohort (Zaragoza Dementia and Depression (ZARADEMP) study) and results from previous studies. ZARADEMP participants (n = 4057) free of dementia were followed up on for up to 12 years. Cases and subcases of anxiety were determined at baseline. A panel of four psychiatrists diagnosed incident cases of VaD by consensus. We searched for similar studies published up to October 2019 using PubMed and Web of Science. Observational studies reporting associations between anxiety and VaD risk, and adjusting at least for age, were selected. Odds ratios (ORs) from each study were combined using fixed-effects models. In the ZARADEMP study, the risk of VaD was 1.41 times higher among individuals with anxiety (95% CI: 0.75–2.68) compared with non-cases (p = 0.288). Pooling this result with results from two previous studies yielded an OR of 1.65 (95% CI: 1.07–2.53; p = 0.022). These findings indicate that anxiety is associated with an increased risk of VaD. Taking into account that anxiety is commonly observed in the elderly, treating and preventing it might reduce the prevalence and incidence of VaD. However, whether anxiety is a cause of a prodrome of VaD is still unknown, and future research is needed to clarify this.

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Section: Sample and Proceduresmentioning

confidence: 99%

Association between Anxiety and Vascular Dementia Risk: New Evidence and an Updated Meta-Analysis

Santabárbara

Lipnicki

Olaya

et al. 2020

JCM

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“…Moreover, anxiety in people with amnestic Mild Cognitive Impairment predicts conversion to AD to a greater degree than memory loss, hippocampal cortex atrophy, or even depression ( Mah et al., 2015 ). The potential pathogenic role of anxiety in AD can be attributed to its negative effects on neuroplasticity and cognitive reserve (i.e., the flexibility or efficiency of cognitive networks) ( Santabarbara et al., 2019 ). Anxiety also shares some underlying etiopathogenic mechanisms with AD, such as inflammation and oxidative damage ( Salim et al., 2012 ).…”

Section: Introductionmentioning

confidence: 99%

High depression and anxiety in people with Alzheimer's disease living in retirement homes during the covid-19 crisis

Haj

Altıntaş

Chapelet

et al. 2020

Psychiatry Research

107

117

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“…Systematic reviews and meta-analysis support anxiety as a major risk factor for dementia [20,21] and AD [22]. Furthermore, we have recently reported that clinically relevant anxiety is a risk factor for overall dementia [23] and AD [24] in the elderly. However, to the best of our knowledge, no dementia risk model has yet included anxiety.…”

Section: Introductionmentioning

confidence: 74%

A Novel Score for Predicting Alzheimer’s Disease Risk from Late Life Psychopathological and Health Risk Factors

Santabárbara

Lipnicki

Cámara

et al. 2021

IJERPH

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With the increasing size of the aging population, dementia risk reduction has become a main public health concern. Dementia risk models or indices may help to identify individuals in the community at high risk to develop dementia. We have aimed to develop a novel dementia risk index focused on the late-life (65 years or more) population, that addresses risk factors for Alzheimer’s disease (AD) easily identifiable at primary care settings. These risk factors include some shown to be associated with the risk of AD but not featured in existing indices, such as hearing loss and anxiety. Our index is also the first to account for the competing risk of death. The Zaragoza Dementia and Depression Project (ZARADEMP) Alzheimer Dementia Risk Score predicts an individual´s risk of developing AD within 5 years. The probability of late onset AD significantly increases in those with risk scores between 21 and 28 and, furthermore, is almost 4-fold higher for those with risk scores of 29 or higher. Our index may provide a practical instrument to identify subjects at high risk of AD and to design preventive strategies targeting the contributing risk factors.

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Clinically relevant anxiety and risk of Alzheimer's disease in an elderly community sample: 4.5 years of follow-up.

Cited by 36 publications

References 26 publications

Association between Anxiety and Vascular Dementia Risk: New Evidence and an Updated Meta-Analysis

Association between Anxiety and Vascular Dementia Risk: New Evidence and an Updated Meta-Analysis

High depression and anxiety in people with Alzheimer's disease living in retirement homes during the covid-19 crisis

A Novel Score for Predicting Alzheimer’s Disease Risk from Late Life Psychopathological and Health Risk Factors

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