Clinically apparent atherosclerotic disease in diabetes is associated with an increase in platelet microparticle levels

Abstract

PMPs are elevated in Type 2 diabetes. In addition, patients with clinically apparent atherosclerosis had the highest levels of PMPs and sPsel. Thus, PMPs may be a marker of symptomatic atherosclerotic vascular disease in Type 2 diabetes, and may both represent a useful risk stratification tool as well as a novel therapeutic target for anti-thrombotic drugs.

Activation of Human Platelets by Misfolded Proteins

“…The results also raise the possibility that the absence of CD36 in 5% of the Asian population offers protection against the platelet-activation component of amyloid-based diseases, a result that has important implications. 34 Recent publications described the presence of amyloid-␤ in platelet-derived microparticles in healthy subjects 35 and in patients with atherosclerotic disease 36 and type 2 Diabetes Mellitus. 37 These particles are a source of tissue factor, which is the prime initiator of coagulation.…”

Assessment of an ELISA Kit for Platelet-Derived Microparticles by Joint Research at Many Institutes in Japan

“…Our first application in the clinical setting was for diabetes mellitus, in which PDMPs may contribute to a prothrombotic state and promote the progression of atherosclerosis, finally resulting in atherosclerosis that can be related to abnormalities in the coagulation and fibrinolytic pathways, as well as in platelet function. In fact, some studies regarding the potential roles of PDMPs in diabetic complications have been carried out using flow cytometric analysis [16][17][18][19][20][21][22] . The present study using an ELISA method produced similar results.…”

Microvesicles and diabetic complications — novel mediators, potential biomarkers and therapeutic targets

“…Studies with human subjects indicate that circulating MVs, such as platelet-derived MVs [97] , CD31 + /annexin V + endothelial-derived MVs [ [98] , and CD144 + endothelial-derived MVs [17,99] , are increased in T2DM patients with macroangiopathy, including coronary, peripheral and cerebrovascular diseases. A recent study reported significantly higher levels of monomeric C-reactive protein (CRP)-positive MVs in patients with myocardial infarction compared with healthy controls [80] .…”