Clinical Worsening in an Adolescent With Pleural Tuberculosis

Cruz, Andrea T.; Starke, Jeffrey R.

doi:10.1016/j.jadohealth.2022.11.013

Cited by 1 publication

(1 citation statement)

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“…9 , 52 The WHO Operational Handbook Module 5 provides further guidance on evaluating and managing hepatotoxicity in children and adolescents on TB treatment. 9 Poor treatment response may be due to suboptimal adherence, incorrect dose calculation, frequent vomiting, poor gastrointestinal absorption of medications (in which therapeutic drug monitoring may assist where available 53 ), drug resistance or an alternative diagnosis. Children and adolescents with and without HIV infection may experience IRIS, which presents as clinical worsening after an initial period of improvement, although IRIS is a diagnosis of exclusion.…”

Section: Standardmentioning

confidence: 99%

Clinical standards for drug-susceptible TB in children and adolescents

Chiang

Graham

Schaaf

et al. 2023

int j tuberc lung dis

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BACKGROUND: These clinical standards aim to provide guidance for diagnosis, treatment, and management of drug-susceptible TB in children and adolescents.METHODS: Fifty-two global experts in paediatric TB participated in a Delphi consensus process. After eight rounds of revisions, 51/52 (98%) participants endorsed the final document.RESULTS: Eight standards were identified: Standard 1, Age and developmental stage are critical considerations in the assessment and management of TB; Standard 2, Children and adolescents with symptoms and signs of TB disease should undergo prompt evaluation, and diagnosis and treatment initiation should not depend on microbiological confirmation; Standard 3, Treatment initiation is particularly urgent in children and adolescents with presumptive TB meningitis and disseminated (miliary) TB; Standard 4, Children and adolescents should be treated with an appropriate weight-based regimen; Standard 5, Treating TB infection (TBI) is important to prevent disease; Standard 6, Children and adolescents should receive home-based/community-based treatment support whenever possible; Standard 7, Children, adolescents, and their families should be provided age-appropriate support to optimise engagement in care and clinical outcomes; and Standard 8, Case reporting and contact tracing should be conducted for each child and adolescent.CONCLUSION: These consensus-based clinical standards, which should be adapted to local contexts, will improve the care of children and adolescents affected by TB.

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Section: Standardmentioning

confidence: 99%