Clinical variables associated with immune checkpoint inhibitor outcomes in patients with metastatic urothelial carcinoma
Soumaya Labidi,
Nicholas Meti,
Reeta Barua
et al.
Abstract:BackgroundAnti-PD-1/L1 immune checkpoint inhibitors (ICI) are indicated for metastatic urothelial cancer (mUC), however, only a minority of patients will derive therapeutic benefit. Strong predictive and prognostic factors are lacking. We investigated if clinical variables were associated with ICI outcomes in mUC.MethodsWe performed a multi-center retrospective cohort study of patients with mUC who received anti-PD-1/L1 ICI for metastatic disease between 2016-2021 at 3 Canadian cancer centres. Clinical charact… Show more
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