Clinical value of triple-energy window scatter correction in simultaneous dual-isotope single-photon emission tomography with123I-BMIPP and201TI

Abstract

To improve the image quality in simultaneous dual-isotope single-photon emission tomography (SPET) with iodine-123 labelled 15-(p-iodophenyl)-3-methylpentadecanoic acid (BMIPP) and thallium-201, we applied the triple-energy window method (TEW) for correction of the cross-talk and scatter artifact. Seventy-one patients with coronary artery disease were included. 201Tl cross-talk into the 123I acquisition window (group 1, n = 30) and 123I cross-talk into the 201Tl window (group 2, n = 41) were studied. In group 1, 123I images were first obtained (single-isotope images), followed by 201Tl injection and SPET acquisition using dual-isotope windows (dual-isotope images). In group 2, the order was reversed. The dual-isotope SPET images with and without TEW were compared with the single-isotope images. Qualitative evaluation was performed by scoring the segmental defect pattern. Detectability of the mismatched fatty acid metabolism on dual-isotope SPET was evaluated by receiver operating characteristic (ROC) curve analysis. Segmental defect pattern agreement between dual and corrected single images was significantly improved by TEW correction (P<0.01). The agreement was particularly improved in segments with absence of uptake. There was no significant difference between TEW-corrected dual-isotope SPET and corresponding single-isotope SPET with regard to either % defect count or background activity. Mismatched fatty acid metabolism depicted by dual-isotope SPET predicted abnormal wall motion more accurately with TEW than without TEW. With TEW, a practical method for scatter and cross-talk correction in clinical settings, simultaneous dual 123I-BMIPP/201Tl SPET is feasible for the assessment of myocardial perfusion/metabolism mismatch.

Tracking transplanted cells using dual-radionuclide SPECT

“…The strength of SPECT, in the present context, lies in its ability to image multiple radionuclides simultaneously. Various combinations of parameters such as fatty acid metabolism, and stress-and rest-perfusion can be measured simultaneously using dual-radionuclide SPECT (Weinmann et al 2003, Yang et al 1997, Berman et al 1994. Such simultaneous imaging decreases scan time and provides perfect image registration.…”

64Cu-ATSM internal radiotherapy to treat tumors with bevacizumab-induced vascular decrease and hypoxia in human colon carcinoma xenografts

“…The triple-energy window method [ 38 ] was used for scatter correction with the following parameters: for 99m Tc, photo peak window was set to a width of 29%; background = 10% on left side and 7% on right side of the photo peak; 16 subsets; 15 iterations; 0.4-mm voxel size; no filter; for 64 Cu, photo peak window was set to a width of 30.2%; background = 10% on left side and 7% on right side of the photo peak; 32 subsets; 15 iterations; 0.4-mm voxel size; and no filter. These parameters were decided based on [ 36 , 39 ]. Registration of the reconstructed SPECT, PET, and CT images was performed with the software (version 2.38c).…”

Multi-peak multi-isotopes myocardial SPECT: It’s easier said than done

“…(Table 1). [7][8][9] Theoretically, to make it possible an accurate simultaneous imaging of multiple isotopes, two ways can be considered: to have detectors with better energy resolution and/or employ complicated scatter and crosstalk correction methods.…”

“…The newest generation cameras take advantages of the increased energy resolution of cadmium zinc telluride (CZT) cameras versus conventional cameras (approximately ? 30%) ( Table 2) 20 to speed up the 8 4.7 40.7 201-Tl:123I 9 14 10…”