Clinical value of thalidomide on kk-rat model through TNF-a mediated inflammation approach

Huang, Min; Duan, Jie; Yu, Bin; Zheng, Silin; Chen, Qi; Lin, Fei; Zeng, Nan; Ling, Baodong

doi:10.1590/fst.06821

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…The major causes of neuronal death in sepsis are the emergence of oxidative stress and the production of proinflammatory cytokines (Huang et al, 2014). The pro-inflammatory factors TNF-α, IL-6, and IL-1β all have a significant impact on sepsis onset and incidence (Huang et al, 2022;Wu et al, 2022;Yang et al, 2022). MDA is a significant byproduct of oxidative damage, and SOD SOD and CAT, particularly SOD1 and SOD2, is thought to be regulated by FOXO1, a metabolic and antioxidant enzyme (Li et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Activation of SIRT1 signaling pathway by clove improves cognitive dysfunction in septic mice

et al. 2022

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Clove is a kind of food spice, which can be used as food flavoring additive. In this work, we looked at clove's impact and underlying mechanism on cognitive impairment in infected mice. By using the open field test, Morris water maze, ELISA technique, kit method, and qPCR method, the biochemical and molecular biological indices of mice were identified. Clove component composition was established using HPLC. The findings demonstrated that clove might enhance mouse survival rates in comparison to the model group and could also lengthen driving distances, standing and combing periods, target quadrant duration, and crossing periods. In the hippocampus of infected mice, clove can lower levels of TNF-α, IL-6, IL-1β, and MDA while increasing SOD and CAT activity. In the hippocampus of infected animals, clove additionally increased the mRNA expression of SIRT1 and FOXO1 and decreased the mRNA expression of NF-B and p53. Animal studies revealed that clove's impact was comparable to dexamethasone in that it might help septic mice with cognitive impairment. The analysis revealed that rutin, isoquercitrin, ferulic acid, dihydroquercetin, and quercitrin were all present in clove. It is clear that clove can help septic mice with cognitive impairment by triggering SIRT1 through its active components.

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Section: Discussionmentioning

confidence: 99%

Activation of SIRT1 signaling pathway by clove improves cognitive dysfunction in septic mice

et al. 2022

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“…The analysis revealed a considerable rise in the pace of granulation of the wounds to which the ointment was administered, as well as a significant improvement in the deposition of collagen fibers and the formation of tissue on the wounds. On the other hand, “SheXiangYuHong” cream can also regulate the expression of Interleukin-6 (IL-6) [ 63 ] and tumor necrosis factor-α (TNF-α) [ 64 ], which are pro-inflammatory factors involved in the inflammatory process, to slow down the inflammatory response. Fei et al [ 65 ], discussed the effects of Shixiang plaster and aminoguanidine on wound healing in diabetic rats.…”

Section: Diabetic Wounds and Diabetic Dressingsmentioning

confidence: 99%

Advances in the Preparation of Nanofiber Dressings by Electrospinning for Promoting Diabetic Wound Healing

Liu

Feng

et al. 2022

Biomolecules

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Chronic diabetic wounds are one of the main complications of diabetes, manifested by persistent inflammation, decreased epithelialization motility, and impaired wound healing. This will not only lead to the repeated hospitalization of patients, but also bear expensive hospitalization costs. In severe cases, it can lead to amputation, sepsis or death. Electrospun nanofibers membranes have the characteristics of high porosity, high specific surface area, and easy functionalization of structure, so they can be used as a safe and effective platform in the treatment of diabetic wounds and have great application potential. This article briefly reviewed the pathogenesis of chronic diabetic wounds and the types of dressings commonly used, and then reviewed the development of electrospinning technology in recent years and the advantages of electrospun nanofibers in the treatment of diabetic wounds. Finally, the reports of different types of nanofiber dressings on diabetic wounds are summarized, and the method of using multi-drug combination therapy in diabetic wounds is emphasized, which provides new ideas for the effective treatment of diabetic wounds.

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Clinical value of thalidomide on kk-rat model through TNF-a mediated inflammation approach

Abstract: The study was carried out since Aug 2019 till Jun 2020, under the principle of good laboratory animal care. The project was approved by the ethics committee of Mianyang Central Hospital for care and use of laboratory animals. The flow chart of the experiment was shown in Figure 1.

Cited by 2 publications

References 19 publications

Activation of SIRT1 signaling pathway by clove improves cognitive dysfunction in septic mice

Activation of SIRT1 signaling pathway by clove improves cognitive dysfunction in septic mice

Advances in the Preparation of Nanofiber Dressings by Electrospinning for Promoting Diabetic Wound Healing

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