Clinical value of serum Ape1/Ref-1 combined with TGF-β1 monitoring in predicting the occurrence of radiation pneumonitis (RP) in non-small cell lung cancer patients

Zhang, Yan; You, Hongjun; Duan, Jun; Gao, Yang

doi:10.21037/apm-21-423

Cited by 4 publications

(1 citation statement)

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“…With the continuous update of radiotherapy technology and equipment, the efficacy of radiotherapy for esophageal cancer has improved. However, radiation-induced lung injury can occur in patients after radiotherapy, which can cause sCAP in severe cases, which significantly affects the patient's quality of life and prognosis and becomes an important factor limiting the increase in clinical radiotherapy dose [13]. erefore, the research on radiation-induced lung injury has attracted more and more attention from scholars at home and abroad.…”

Section: Discussionmentioning

confidence: 99%

Serum MMP-9 and SAA in the Diagnosis of Severe Pneumonia Caused by Radiotherapy of Esophageal Cancer

Zhou

Liu

2021

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the relationship and diagnostic value of serum MMP-9 and SAA in severe pneumonia (sCAP) caused by radiotherapy of esophageal cancer. Methods. A total of 144 esophageal cancer patients who underwent radiotherapy in our hospital from April 2016 to February 2018 were collected. Among them, 58 patients without radiation pneumonitis (RP) were in the control group, 49 patients with grade 1∼2 RP were in the radiation group, and 37 patients with sCAP were in the severe group. The levels of serum MMP-9 and SAA in every group of patients were detected. The ROC curve was used to determine the diagnostic value of serum MMP-9 and SAA in the diagnosis of RP and sCAP. The correlation between serum MMP-9 and SAA and the patient’s lung function indexes was analyzed, and the logistic single-factor and multivariate analyses were performed to analyze the factors of sCAP in esophageal cancer radiotherapy. Results. PaO2, FVC, and FEV1 decreased in RP and sCAP, and PaCO2, white blood cells, serum MMP-9, and SAA levels increased ( P < 0.05 ); serum MMP-9 and SAA were negatively correlated with lung function ( P < 0.05 ); the AUC of serum MMP-9 and SAA in RP was 0.833 and 0.823, respectively, and the AUC of the two combined diagnosis of RP was 0.919. The AUC of serum MMP-9 and SAA in sCAP was 0.809 and 0.797, respectively, and the AUC of both combined diagnosis of sCAP was 0.873; logistics multivariate analysis found that serum MMP-9, serum SAA, double lung V5, and V20 were independent risk factors for sCAP caused by radiotherapy for esophageal cancer ( P < 0.05 ). Conclusion. Serum MMP-9 and SAA increase in RP and sCAP and are negatively correlated with lung function in patients with pneumonia. They are independent risk factors for severe pneumonia caused by radiotherapy of esophageal cancer and have good diagnostic value.

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Section: Discussionmentioning

confidence: 99%