Clinical value of Naa10p and <scp>CEA</scp> levels in saliva and serum for diagnosis of oral squamous cell carcinoma

Zheng, Jun; Sun, Lichun; Wei, Yuan; Xu, Jianmin; Yu, Xiao; Wang, Fazhan; Sun, Lisha; Zeng, Yan

doi:10.1111/jop.12767

Cited by 30 publications

(23 citation statements)

References 27 publications

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“…Several studies have proposed the evaluation of the salivary and serum levels of IL-6 and/or IL-8 as promising biomarkers for oral cancer lesions, however, the sensitivity and specificity of these markers were low because they increase also in presence of various oral cavity inflammatory conditions [21,22]. Other studies focused the attention on tumor markers already used for the diagnosis of other solid tumors, such as the salivary levels of the carcino-embryonic antigen (CEA; 68.9% sensitivity, 73.3% specificity) [23], carcinoantigen 19-9 (CA19-9; no diagnostic value) [24] and CA125 (80.0% sensitivity, 66.0% specificity) [25]. However, the sensitivity and specificity of these markers were not high enough to diagnose effectively all oral tumors.…”

Section: Introductionmentioning

confidence: 99%

Identification of Novel MicroRNAs and Their Diagnostic and Prognostic Significance in Oral Cancer

Falzone

Lupo

Rosa

et al. 2019

Cancers

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Background: Oral cancer is one of the most prevalent cancers worldwide. Despite that the oral cavity is easily accessible for clinical examinations, oral cancers are often not promptly diagnosed. Furthermore, to date no effective biomarkers are available for oral cancer. Therefore, there is an urgent need to identify novel biomarkers able to improve both diagnostic and prognostic strategies. In this context, the development of innovative high-throughput technologies for molecular and epigenetics analyses has generated a huge amount of data that may be used for the identification of new cancer biomarkers. Methods: In the present study, GEO DataSets and TCGA miRNA profiling datasets were analyzed in order to identify miRNAs with diagnostic and prognostic significance. Furthermore, several computational approaches were adopted to establish the functional roles of these miRNAs. Results: The analysis of datasets allowed for the identification of 11 miRNAs with a potential diagnostic role for oral cancer. Additionally, eight miRNAs associated with patients’ prognosis were also identified; six miRNAs predictive of patients’ overall survival (OS) and one, hsa-miR-let.7i-3p, associated with tumor recurrence. Conclusion: The integrated analysis of different miRNA expression datasets allows for the identification of a set of miRNAs that, after validation, may be used for the early detection of oral cancers.

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Section: Introductionmentioning

confidence: 99%

Identification of Novel MicroRNAs and Their Diagnostic and Prognostic Significance in Oral Cancer

Falzone

Lupo

Rosa

et al. 2019

Cancers

View full text Add to dashboard Cite

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“…They also found a correlation of salivary Naa10p level in OSCC patients with the degree of differentiation and lymph node metastasis and the salivary CEA level with the clinical stage and lymph node metastasis. The diagnostic performance of the combined approach improved the early detection rate of OSCC more than any of the two single approaches . Combination of zinc‐α‐2‐glycoprotein and peroxiredoxin‐2 protein yielded a significant discriminatory power in distinguishing the early‐ and advanced‐stage OSCC .…”

Section: Biomarkers In Oscc and Esccmentioning

confidence: 96%

Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas

Khan

Relitti

Brindisi

et al. 2019

Medicinal Research Reviews

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Oral squamous cell carcinomas (OSCC) and esophageal squamous cell carcinomas (ESCC) exhibit a survival rate of less than 60% and 40%, respectively. Late-stage diagnosis and lack of effective treatment strategies make both OSCC and ESCC a significant health burden. Autophagy, a lysosome-dependent catabolic process, involves the degradation of intracellular components to maintain cell homeostasis. Targeting autophagy has been highlighted as a feasible therapeutic strategy with clinical utility in cancer treatment, although its associated regulatory mechanisms remain elusive. The detection of relevant biomarkers in biological fluids has been anticipated to facilitate early diagnosis and/or prognosis for these tumors. In this context, recent studies have indicated the presence of specific proteins and small RNAs, detectable in circulating plasma and serum, as biomarkers. Interestingly, the interplay between biomarkers (eg, exosomal microRNAs) and autophagic processes could be exploited in the quest for targeted and more effective therapies for OSCC and ESCC. In this review, we give an overview of the available biomarkers and innovative targeted therapeutic strategies, including the application of autophagy modulators in OSCC and ESCC.Additionally, we provide a viewpoint on the state of the art Tuhina Khan and Nicola Relitti contributed equally to this work. and on future therapeutic perspectives combining the early detection of relevant biomarkers with drug discovery for the treatment of OSCC and ESCC. K E Y W O R D S autophagy, autophagy modulators, biomarkers, esophageal squamous cell carcinoma, exosomes, oral squamous cell carcinoma, targeted therapy 1 | INTRODUCTION Oral squamous cell carcinoma (OSCC) is the predominant malignant neoplasm of the oral cavity followed by verrucous carcinoma, undifferentiated carcinoma, and small salivary adenocarcinoma. 1 Esophageal squamous cell carcinoma (ESCC) is the first histological type and accounts for 80% of cases of esophageal cancer. 2 OSCC and ESCC are indicated as one of the most common cancers by the International Union Against Cancer with an annual incidence of 275 000 and 456 000 cases worldwide, respectively. 3,4 The primary etiology in both OSCC and ESCC is attributed to the environmental factors (tobacco abuse, alcohol consumption), genetic factors (eg, mutations in enzymes), viral factors (human papilloma virus [HPV] infection), and/or the coexistence of these factors. Alcohol intake and tobacco use are responsible for at least 75% of these carcinomas. The underlying initiation and progression mechanisms of OSCC and ESCC are generally characterized by the accumulation of serial epigenetic and genetic alterations, which eventually lead to uncontrolled proliferation of the mutated cells, followed by vigorous cell division. 5,7 Early-stage OSCC detection displays an 80% survival rate at 5 years, while detection at advanced stage leads to survival rates ranging from 20% to 40%. 6 In ESCC, the 5-year survival rate for early-stage detection may reach 85%, whereas a dr...

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“…Despite the fact that the oral cavity can be readily to examined, most tumours are diagnosed in the late stage, which reduces the survival rate of patients [90]. The markers of solid tumours used so far, such as carcinoembryonic antigen or carcinoantigen 19-9, have not shown sufficiently high sensitivity and specificity in the effective diagnosis of all oral cancers [91,92]. It is known that some miRNAs are specifically associated with the presence of neoplasms, even in the early stages, which is important for the diagnosis of this neoplasm [93].…”

Section: Mirna In Ebv and Hpv-associated Cancersmentioning

confidence: 99%

The role of microRNA (miRNA) as a biomarker in HPV and EBV-related cancers

Koleśnik¹,

Stępień²,

Polz‐Dacewicz³

2021

J Pre Clin Clin Res.

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Introduction and objective. Biomarkers are measurable biological indicators of many disease states. Particularly noteworthy are short nucleotide sequences involved in the regulation of many cellular processes. Their level in body fluids constitutes an important biological marker of serious diseases, such as cancer or cardiovascular diseases. For example, different types of microRNA may be used as biomarker in virus-associated cancers. The aim of this article was to review the current knowledge on the miRNAs and their role in viral-related cancers (EBV and HPV). The article reviews information available in journals and on electronic databases. Brief description of the state of knowledge. A significant part of the world's population hosts at least one of the oncoviruses, but only a small percentage of them undergo a cancerogenesis to which these infectious agents contribute. Interaction between the host cell and viral factors can lead to the origination of a microenvironment favourable to oncogenesis. Cancer arises as a result of dysregulation in many cellular processes, and particularly important are short RNA sequences which regulate the processes that can cause this disease. The varied expression of this ribonucleic acid contributes to many diseases and provides valuable information about health. Importantly, these molecules are differentially expressed in virally-induced cancer. Many publications have confirmed the relationship between the expression of specific types of miRNA and cancers associated with EBV and HPV. Conclusions. The use of miRNAs as biomarkers of neoplastic diseases associated with EBV and HPV infections may significantly contribute to the reduction of mortality caused by these viruses, and thanks to the development of modern technologies they are an attractive research object.

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Clinical value of Naa10p and CEA levels in saliva and serum for diagnosis of oral squamous cell carcinoma

Abstract: Combined use of salivary Naa10p and CEA as tumor markers for OSCC was more sensitive than serum Naa10p and CEA. These results indicated that combined detection of salivary Naa10p and CEA improved diagnostic performance and early detection rate for OSCC.

Cited by 30 publications

References 27 publications

Identification of Novel MicroRNAs and Their Diagnostic and Prognostic Significance in Oral Cancer

Identification of Novel MicroRNAs and Their Diagnostic and Prognostic Significance in Oral Cancer

Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas

The role of microRNA (miRNA) as a biomarker in HPV and EBV-related cancers

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